Peptide Nucleic Acid. A Molecule with Two Identities
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPeptide Nucleic Acid. A Molecule with Two IdentitiesPeter E. NielsenView Author Information Center for Biomolecular Recognition, Department of Medical Biochemistry & Genetics, Biochemical Laboratory B, The Panum Institute, Blegdamsvej 3c, 2200 Copenhagen N, Denmark Cite this: Acc. Chem. Res. 1999, 32, 7, 624–630Publication Date (Web):April 1, 1999Publication History Received29 September 1998Published online1 April 1999Published inissue 1 July 1999https://pubs.acs.org/doi/10.1021/ar980010thttps://doi.org/10.1021/ar980010tresearch-articleACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views3536Altmetric-Citations334LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical structure,Genetics,Hybridization,Nucleobases,Peptides and proteins Get e-Alerts
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PNA:DNA duplex has high stability.
“We opted for PNA based on the high stability of the PNA:DNA duplex and the simplicity of its chemistry (Figure 1, this work).32−34”
From Sequencing of <scp>d</scp>/<scp>l</scp>-DNA and XNA by Templated-Synthesis (2025) · cites this paper as [33]
Cites
Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits
Tang, W.-J., & Gilman, A. G. (1991) · Science · doi:10.1126/science.1962211 · Cited by 1,091 · see citing works
The search for missing links between self-replicating nucleic ACIDs and the RNA world
James, K. D., & Ellington, A. D. (1995) · Origins of life and evolution of the biosphere · doi:10.1007/bf01582021 · Cited by 39 · see citing works
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Prebiotic Peptides: Molecular Hubs in the Origin of Life
Frenkel-Pinter, M., Samanta, M., Ashkenasy, G., & Leman, L. J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00664 · Cited by 354 · see citing works
A Simple γ-Backbone Modification Preorganizes Peptide Nucleic Acid into a Helical Structure
Dragulescu-Andrasi, A., Rapireddy, S., Frezza, B. M., Gayathri, C., Gil, R. R., & Ly, D. H. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0625576 · Cited by 286 · see citing works
Some consequences of the RNA world hypothesis
Orgel, L. E. (2003) · Origins of life and evolution of the biosphere · doi:10.1023/a:1024616317965 · Cited by 124 · see citing works
PNA as a Biosupramolecular Tag for Programmable Assemblies and Reactions
Barluenga, S., & Winssinger, N. (2015) · Accounts of Chemical Research · doi:10.1021/acs.accounts.5b00109 · Cited by 77 · see citing works
Sequencing of <scp>d</scp>/<scp>l</scp>-DNA and XNA by Templated-Synthesis
Joshi, S., Romanens, P., & Winssinger, N. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c00708 · Cited by 4 · see citing works
- Authors
- Nielsen, P. E.
- Affiliations
- Center for Biomolecular Recognition, Department of Medical Biochemistry & Genetics, Biochemical Laboratory B, The Panum Institute, Blegdamsvej 3c, 2200 Copenhagen N, Denmark
- Corresponding author
- Nielsen, Peter E.
- ORCID
- Nielsen, Peter E.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 1999-04-01
- Volume
- 32
- Issue
- 7
- Pages
- 624-630
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W2950702549
- Cited by
- 380
- References
- 2
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 2 · 2023: 11 · 2022: 8 · 2021: 12 · 2020: 17 · 2019: 13 · 2018: 13 · 2017: 8 · 2016: 11 · 2015: 22 · 2014: 13 · 2013: 15 · 2012: 22
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Accounts of Chemical Research (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- peptide nucleic acid, PNA, nucleic acid mimics, nucleic acid hybridization, nucleobases, PNA-DNA duplex
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