Some consequences of the RNA world hypothesis

Orgel, Leslie E.

doi:10.1023/a:1024616317965

Cited by 124Origins and Evolution of LifeRNA and protein synthesis mechanismsEvolution and Genetic Dynamics

Some consequences of the RNA world hypothesis

Orgel, Leslie E.·2003·Origins of life and evolution of the biosphere

DOI 10.1023/a:1024616317965

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Abstract

It is now generally accepted that our familiar biological world was preceded by an RNA world in which ribosome-catalyzed, nucleic-acid coded protein synthesis played no part. If the RNA world was the first biological world there is little that one can learn from biochemistry about prebiotic chemistry, except that the formation and polymerization of nucleotides were once prebiotic processes. If the RNA world was not the first biological world, the above conclusion may not be justified, and one can speculate that the monomers of earlier genetic polymers might be recognizable as important biochemicals. This suggests that the construction of replicating polymers from simple, not necessarily standard, aminoacids should be explored.

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Polyesters have a considerably lower energy for bond formation (~0 kcal mol−1) and have been considered as possible ancestral precursors of peptides.
“Alternatively, polyesters, which have a considerably lower energy for bond formation (~0 kcal mol−1 [54]), have been considered as possible ancestral precursors of peptides [36,55].”
From Polyesters as a Model System for Building Primitive Biologies from Non-Biological Prebiotic Chemistry (2020) · cites this paper as [55]

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Authors: Orgel, L. E.
Affiliations: Salk Institute for Biological Studies (US)
Corresponding author: Orgel, Leslie E.
Venue: Origins of life and evolution of the biosphere
Publisher: Springer Science and Business Media LLC
Published: 2003-04
Volume: 33
Issue: 2
Pages: 211-218
ISSN: 0169-6149 (ISSN-L)
1573-0875
DOI: 10.1023/a:1024616317965
OpenAlex: W1567188373
Cited by: 124
References: 19
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 4 · 2017: 6 · 2016: 2 · 2015: 9 · 2014: 3 · 2013: 1 · 2012: 7
FWCI: 8.49
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Origins of Life and Evolution of Biospheres (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: RNA world, prebiotic chemistry, origin of life, nucleotide polymerization, amino acids, ribozymes, protein synthesis
MeSH terms: Amino Acids, Models, Theoretical, Polymers, RNA

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