Cited by 583Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsRNA Interference and Gene Delivery

Multifunctional and stimuli-sensitive pharmaceutical nanocarriers

Open access
Torchilin, Vladimir·2009·European Journal of Pharmaceutics and Biopharmaceutics

Abstract

Currently used pharmaceutical nanocarriers, such as liposomes, micelles, and polymeric nanoparticles, demonstrate a broad variety of useful properties, such as longevity in the body; specific targeting to certain disease sites; enhanced intracellular penetration; contrast properties allowing for direct carrier visualization in vivo; stimuli-sensitivity, and others. Some of those pharmaceutical carriers have already made their way into clinic, while others are still under preclinical development. In certain cases, the pharmaceutical nanocarriers combine several of the listed properties. Long-circulating immunoliposomes capable of prolonged residence in the blood and specific target recognition represent one of the examples of this kind. The engineering of multifunctional pharmaceutical nanocarriers combining several useful properties in one particle can significantly enhance the efficacy of many therapeutic and diagnostic protocols. This paper considers the current status and possible future directions in the emerging area of multifunctional nanocarriers with primary attention on the combination of such properties as longevity, targetability, intracellular penetration, contrast loading, and stimuli-sensitivity.

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Crossref · 10.1016/j.ejpb.2008.09.026

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  • Selective delivery is achieved via novel design of various stimuli-responsive nanomicelles that release drugs based on endogenous or exogenous stimulations such as pH, temperature, ultrasound, light, redox potential, and others.

    “Selective delivery is achieved via novel design of various stimuli-responsive nanomicelles that release drugs based on endogenous or exogenous stimulations such as pH, temperature, ultrasound, light, redox potential, and others.”

    From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [19]

    Section III describes polymeric micelles that release drugs in response to pH, temperature, and ultrasound, and discusses redox-responsive drug release from nanocarriers. It does not establish light-triggered release or redox-triggered release specifically from micelles. The Introduction also presents selective, stimulus-responsive delivery partly as a design goal rather than an achievement across all the listed stimuli. (LLM, conf=0.86)

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5 of the 269 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

  1. [1]Torchilin VP Nanoparticualtes as Pharmaceutical carriers 2006 Imperial College Press London, UK
  2. [12]Lasic DD Martin FJ Stealth liposomes 1995 CRC Press Boca Raton
  3. [57]Torchilin VP Rammohan R Weissig V Khaw BA Klibanov A Samokhin GP PEG-Immunoliposomes: attachment of monoclonal antibody to distal ends of PEG chains via p-Nitrophenylcarbonyl groups 2000 217 218 27th International Symposium on Controlled Release of Bioactive Materials Controlled Release Society, Inc Paris
  4. [116]Lee E Na K Bae Y Super pH-sensitive multifunctional polymeric micelle Nano Lett 2005 5 325 329 15794620
  5. [241]Tilcock C Gregoriadis G Liposomal paramagnetic magnetic resonance contrast agents Liposome technology 1993 vol. 2 65 87 CRC Press Boca Raton, Fla.
  6. [259]Torchilin VP Trubetskoy VS Narula J Khaw BA Lasic DD Martin FJ PEG-modified liposomes for gamma- and magentic resonance imaging Stealth liposomes 1995 225 231 CRC Press Boca Raton

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Authors
Torchilin, V.
Affiliations
Northeastern University (US)
Corresponding author
Torchilin, Vladimir
Venue
European Journal of Pharmaceutics and Biopharmaceutics
Publisher
Elsevier BV
Published
2009-03
Volume
71
Issue
3
Pages
431-444
ISSN
0939-6411 (ISSN-L)
OpenAlex
W2046772999
Cited by
583
References
269
Citations by year
2026: 21 · 2025: 11 · 2024: 12 · 2023: 19 · 2022: 25 · 2021: 17 · 2020: 28 · 2019: 27 · 2018: 29 · 2017: 41 · 2016: 50 · 2015: 53 · 2014: 52 · 2013: 43 · 2012: 57
FWCI
1.52
Type
journal article
Language
en
Open access
Locations
  • European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (R01CA121838)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords
multifunctional nanocarriers, stimuli-responsive drug delivery, long-circulating liposomes, immunoliposomes, targeted drug delivery, intracellular penetration, contrast media, polymeric nanoparticles, micelles
MeSH terms
Animals, Biological Transport, Chemistry, Pharmaceutical, Delayed-Action Preparations, Drug Carriers, Humans, Liposomes, Micelles, Polymers, Drug Delivery Systems, Nanoparticles

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