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Cited by 332

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Polyester Dendritic Systems for Drug Delivery Applications: Design, Synthesis, and Characterization

Ihre, Henrik R., Padilla De Jesús, Omayra L., Szoka,, Francis C., Fréchet, Jean M. J.·2002·Bioconjugate Chemistry
DOI 10.1021/bc010102u
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Abstract

Attachment of drugs to high molecular weight polymers can significantly improve both tumor targeting and therapeutic efficacy due to the enhanced permeability and retention effect observed in tumor tissue. However, the commercial availability of well-defined water-soluble polymeric systems with narrow polydispersities that are biocompatible, nontoxic, and nonimmunogenic is rather limited. To address this need, we have investigated dendritic polymers as promising scaffolds for the preparation of new soluble polymeric drug carriers due to their well-defined molecular architecture and their multiplicity of surface sites. Herein we show the design and synthesis of dendritic polyester systems based on the monomer unit 2,2-bis(hydroxymethyl)propanoic acid as a possible versatile drug carrier. The potent anticancer drug doxorubicin was attached via a pH-sensitive linkage to one of the carriers presented, demonstrating the feasibility of using these polyester dendritic structures to prepare a viable polymer-drug conjugate.

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Metadata

Authors
Ihre, H. R., Padilla De Jesús, O. L., Szoka, & Fréchet, J. M. J.
Venue
Bioconjugate Chemistry
Publisher
American Chemical Society (ACS)
Published
2002-04-24
Volume
13
Issue
3
Pages
443-452
ISSN
  • 1043-1802 (ISSN-L)
  • 1520-4812
DOI
10.1021/bc010102u
OpenAlex
W2031780453
Cited by
332
References
40
FWCI
21.92
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.