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Visualization of the Degradation of a Disulfide Polymer, Linear Poly(ethylenimine sulfide), for Gene Delivery
Abstract
Polyethylenimine (PEI) shows high transfection efficiency and cytoxicity due to its high amine density. The new disulfide cationic polymer, linear poly(ethylenimine sulfide) (l-PEIS), was synthesized for efficient and safe gene delivery. As the amine density of l-PEIS increased, the transfection efficiency also increased. l-PEIS-6 and l-PEIS-8 show transfection efficiencies that are similar to that of PEI. However, cytotoxicity of l-PEIS was not observed due to the biodegradable disulfide bond. The disulfide bonds are stable in the oxidative extracellular condition and can be degraded rapidly in the reductive intracellular condition. The degradation of l-PEIS in HeLa cells was visualized by fluorescence microscopy using the probe-probe dequenching effect of BODIPY-FL fluorescence dye. l-PEIS was degraded completely within 3 h.
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Citations
Cited by
Nonviral vectors for gene delivery
Mintzer, M. A., & Simanek, E. E. (2009) · Chemical Reviews · doi:10.1021/cr800409e · Cited by 2,366
Lee, Y., Ishii, T., Cabral, H., Kim, H. J., Seo, J., Nishiyama, N., Oshima, H., Osada, K., & Kataoka, K. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900064 · Cited by 351
Self-citationDelivery of Nucleic Acids via Disulfide‐Based Carrier Systems
Bauhuber, S., Hozsa, C., Breunig, M., & Göpferich, A. (2009) · Advanced Materials · doi:10.1002/adma.200802453 · Cited by 278
Gene therapy progress and prospects: synthetic polymer-based systems
Schaffert, D., & Wagner, E. (2008) · Gene Therapy · doi:10.1038/gt.2008.105 · Cited by 277
Metadata
- Authors
- Lee, Y., Mo, H., Koo, H., Park, J.-Y., Cho, M. Y., Jin, G.-W., & Park, J.-S.
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-12-23
- Volume
- 18
- Issue
- 1
- Pages
- 13-18
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W1993553186
- Cited by
- 184
- References
- 0
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, Y., Mo, H., Koo, H., Park, J.-Y., Cho, M. Y., Jin, G.-W., & Park, J.-S. (2007). Visualization of the Degradation of a Disulfide Polymer, Linear Poly(ethylenimine sulfide), for Gene Delivery. Bioconjugate Chemistry. https://doi.org/10.1021/bc060113t
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