The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.
Delivery of Nucleic Acids via Disulfide‐Based Carrier Systems
Abstract
Nucleic acids are not only expected to assume a pivotal position as “drugs” in the treatment of genetic and acquired diseases, but could also act as molecular cues to control the microenvironment during tissue regeneration. Despite this promise, the efficient delivery of nucleic acids to their side of action is still the major hurdle. One among many prerequisites for a successful carrier system for nucleic acids is high stability in the extracellular environment, accompanied by an efficient release of the cargo in the intracellular compartment. A promising strategy to create such an interactive delivery system is to exploit the redox gradient between the extra‐ and intracellular compartments. In this review, emphasis is placed on the biological rationale for the synthesis of redox sensitive, disulfide‐based carrier systems, as well as the extra‐ and intracellular processing of macromolecules containing disulfide bonds. Moreover, the basic synthetic approaches for introducing disulfide bonds into carrier molecules, together with examples that demonstrate the benefit of disulfides at the individual stages of nucleic acid delivery, will be presented.
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Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070
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Self-Cross-Linked Polymer Nanogels: A Versatile Nanoscopic Drug Delivery Platform
Ryu, J.-H., Chacko, R. T., Jiwpanich, S., Bickerton, S., Babu, R. P., & Thayumanavan, S. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1069932 · Cited by 553
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Metadata
- Authors
- Bauhuber, S., Hozsa, C., Breunig, M., & Göpferich, A.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2009-08-28
- Volume
- 21
- Issue
- 32-33
- Pages
- 3286-3306
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2075302245
- Cited by
- 278
- References
- 178
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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