The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Headgroup Evolution of Cationic Lipids for Gene Delivery
Abstract
Cationic lipids are one of the most widely used nonviral vectors for gene delivery and are especially attractive because they can be easily synthesized and extensively characterized. Additionally, they can best facilitate the elucidation of structure-activity relationships by modifying each of their constituent domains. The polar hydrophilic headgroups enable the condensation of nucleic acids by electrostatic interactions with the negatively charged phosphate groups of the genes, and further govern transfection efficiency. The headgroups of cationic lipids play a crucial role for gene delivery; they can be quaternary ammoniums, amines, aminoacids or peptides, guanidiniums, heterocyclic headgroups, and some unusual headgroups. This review summarizes recent research results concerning the nature (such as the structure and shape of cationic headgroup) and density (such as the number and the spacing of cationic headgroup) of head functional groups for improving the design of efficient cationic lipids to overcome the critical barriers of in vitro and in vivo transfection.
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Cites
Direct Gene Transfer into Mouse Muscle in Vivo
Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., & Felgner, P. L. (1990) · Science · doi:10.1126/science.1690918 · Cited by 4,173
Nonviral vectors for gene delivery
Mintzer, M. A., & Simanek, E. E. (2009) · Chemical Reviews · doi:10.1021/cr800409e · Cited by 2,366
Toxicity of cationic lipids and cationic polymers in gene delivery
Lv, H., Zhang, S., Wang, B., Cui, S., & Yan, J. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.014 · Cited by 2,286
Self-citationRational design of cationic lipids for siRNA delivery
Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W. Y., Stebbing, D., Crosley, E. J., Yaworski, E., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1602 · Cited by 1,822
Cited by
Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery
Buck, J., Grossen, P., Cullis, P. R., Huwyler, J., & Witzigmann, D. (2019) · ACS Nano · doi:10.1021/acsnano.8b07858 · Cited by 312
The transfection efficiency of calix[4]arene-based lipids: the role of the alkyl chain length
Mochizuki, S., Nishina, K., Fujii, S., & Sakurai, K. (2015) · Biomaterials Science · doi:10.1039/c4bm00303a · Cited by 11
Metadata
- Authors
- Zhi, D., Zhang, S., Cui, S., Zhao, Y., Wang, Y., & Zhao, D.
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-04-04
- Volume
- 24
- Issue
- 4
- Pages
- 487-519
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W2027774836
- Cited by
- 271
- References
- 4
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhi, D., Zhang, S., Cui, S., Zhao, Y., Wang, Y., & Zhao, D. (2013). The Headgroup Evolution of Cationic Lipids for Gene Delivery. Bioconjugate Chemistry. https://doi.org/10.1021/bc300381s
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