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Calcium induces transbilayer redistribution of all major phospholipids in human erythrocytes
Abstract
Elevating cytoplasmic Ca2+ levels in erythrocytes activates a pathway for transbilayer diffusion of plasma membrane phospholipids. The use of spin-labeled and fluorescent phospholipid analogues revealed that the pathway permits diffusion of all the major classes of phospholipids and does not distinguish between the two types of probes. Diffusion was bidirectional, began immediately upon elevation of cytoplasmic [Ca2+] above 50-100 microM, persisted as long as the [Ca2+] remained elevated, and disappeared promptly when Ca2+ levels fell. Diffusion was unaffected by conditions which suppress shedding of vesicles, discounting this event as a requisite for phospholipid reorientation induced by Ca2+.
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Citations
Cited by
Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells
Zwaal, R. F. A., & Schroit, A. J. (1997) · Blood · doi:10.1182/blood.v89.4.1121 · Cited by 1,340
Verhoven, B., Schlegel, R. A., & Williamson, P. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1597 · Cited by 666
Self-citationBratton, D. L., Fadok, V. A., Richter, D. A., Kailey, J. M., Guthrie, L. A., & Henson, P. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.42.26159 · Cited by 485
Molecular Cloning of Human Plasma Membrane Phospholipid Scramblase
Zhou, Q., Zhao, J., Stout, J. G., Luhm, R. A., Wiedmer, T., & Sims, P. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.18240 · Cited by 383
Kuypers, F., Lewis, R., Hua, M., Schott, M., Discher, D., Ernst, J., & Lubin, B. (1996) · Blood · doi:10.1182/blood.v87.3.1179.bloodjournal8731179 · Cited by 297
Metadata
- Authors
- Williamson, P., Kulick, A., Zachowski, A., Schlegel, R. A., & Devaux, P. F.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1992-07-01
- Volume
- 31
- Issue
- 27
- Pages
- 6355-6360
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2079936146
- Cited by
- 191
- References
- 0
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Calcium induces transbilayer redistribution of all major phospholipids in human erythrocytes. https://app.cochat.ai/papers/10.1021/bi00142a027
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- Williamson, P., Kulick, A., Zachowski, A., Schlegel, R. A., & Devaux, P. F. (1992). Calcium induces transbilayer redistribution of all major phospholipids in human erythrocytes. Biochemistry. https://doi.org/10.1021/bi00142a027
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
