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Cited by 419

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Purification and sequence of a presynaptic peptide toxin from Conus geographus venom

Olivera, Baldomero M., McIntosh, J. Michael, Curz, Lourdes J., Luque, F. A., Gray, William R.·1984·Biochemistry
DOI 10.1021/bi00317a001
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Abstract

A novel toxin, omega-conotoxin (omega-CgTX), from the venom of the fish-eating marine mollusc Conus geographus has been purified and biochemically characterized. Recently, this omega-conotoxin has been shown to inhibit the voltage-activated entry of Ca2+, thus providing a potentially powerful probe for exploring the vertebrate presynaptic terminal [Kerr, L. M., & Yoshikami, D. (1984) Nature (London) 308, 282-284]. The toxin is a basic 27 amino acid peptide amide with three disulfide bridges. An unusual feature is a remarkable preponderance of hydroxylated amino acids. The sequence of omega-CgTx GVIA is Cys-Lys-Ser- Hyp-Gly5-Ser-Ser-Cys-Ser-Hyp10-Thr-Ser-Tyr-Asn-Cys15-C ys-Arg-Ser- Cys-Asn20-Hyp-Tyr-Thr-Lys-Arg25-Cys-Tyr-NH2.

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Metadata

Authors
Olivera, B. M., McIntosh, J. M., Curz, L. J., Luque, F. A., & Gray, W. R.
Venue
Biochemistry
Publisher
American Chemical Society (ACS)
Published
1984-10-01
Volume
23
Issue
22
Pages
5087-5090
ISSN
  • 0006-2960 (ISSN-L)
  • 1520-4995
DOI
10.1021/bi00317a001
OpenAlex
W2066787103
Cited by
419
References
0
FWCI
8.42
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Purification and sequence of a presynaptic peptide toxin from Conus geographus venom. https://app.cochat.ai/papers/10.1021/bi00317a001
The paper
Olivera, B. M., McIntosh, J. M., Curz, L. J., Luque, F. A., & Gray, W. R. (1984). Purification and sequence of a presynaptic peptide toxin from Conus geographus venom. Biochemistry. https://doi.org/10.1021/bi00317a001

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