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Peptide repeats in a mussel glue protein: theme and variations
Abstract
The adhesive protein from Mytilus edulis contains 75-80 closely related, repeated peptide sequences in its primary structure. These peptides can be resolved following digestion with trypsin by reversed-phase high-pressure liquid chromatography. The most frequently repeated sequence is the decapeptide Ala-Lys-Pro-Ser-Tyr-Hyp-Hyp-Thr-Dopa-Lys (peptide E). Variations of this occur in peptides B with Hyp-3 and Dopa-5, C with Dopa-5, and D with Hyp-3, respectively. Lesser amounts of hexapeptides (A and B') that are lacking residues 4-7 also occur. Peptide A has the sequence Ala-Lys-Pro-Thr-Dopa-Lys, whereas B' contains Tyr instead of Dopa. 4-Hydroxyproline occurs at positions 3 and 7 and occasionally at position 6 of the decapeptide; 3-hydroxyproline occurs only at position 6. Adhesiveness of the protein may be related to the repetition of Dopa residues, the catecholic moiety of which has strong hydrogen-bonding and metal-liganding capabilities.
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Citations
Cited by
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Self-citationMussel Adhesive Protein Mimetic Polymers for the Preparation of Nonfouling Surfaces
Dalsin, J. L., Hu, B.-H., Lee, B. P., & Messersmith, P. B. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0284963 · Cited by 585
Adhesion mechanisms of the mussel foot proteins mfp-1 and mfp-3
Lin, Q., Gourdon, D., Sun, C., Holten-Andersen, N., Anderson, T. H., Waite, J. H., & Israelachvili, J. N. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607852104 · Cited by 559
Self-citationBio-inspired adhesive catechol-conjugated chitosan for biomedical applications: A mini review
Ryu, J. H., Hong, S., & Lee, H. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.08.043 · Cited by 428
Metadata
- Authors
- Waite, J. H., Housley, T. J., & Tanzer, M. L.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1985-09
- Volume
- 24
- Issue
- 19
- Pages
- 5010-5014
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2079897195
- Cited by
- 208
- References
- 0
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Waite, J. H., Housley, T. J., & Tanzer, M. L. (1985). Peptide repeats in a mussel glue protein: theme and variations. Biochemistry. https://doi.org/10.1021/bi00340a008
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