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Phase equilibriums in binary mixtures of phosphatidylcholine and cholesterol
Abstract
The paramagnetic resonance spectra of two spin-labels, 2,2,6,6-tetramethylpiperadinyl-1-oxy and a head-group spin-labeled phosphatidylethanolamine (L-alpha-dipalmitoylphosphatidyl-N-ethanolamine), have been used to study solid-liquid and liquid-liquid phase separations in binary mixtures of dimyristoylphosphatidylcholine and cholesterol. A quantitative analysis of these resonance spectra supports the view that at temperatures below theta m, the chain-melting temperature of the phospholipid, and at cholesterol mole fractions Xc less than 0.2, these mixtures consist of two phases, a solid phase of essentially pure dimyristoylphosphatidylcholine and a fluid phase having a mole fraction of cholesterol equal to 0.2. The spin-label data also provide evidence for fluid-fluid immiscibility in the bilayer membrane at temperatures above the chain melting transition temperature of dimyristoylphosphatidylcholine.
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Citations
Cited by
Membrane lipids: where they are and how they behave
van Meer, G., Voelker, D. R., & Feigenson, G. W. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2330 · Cited by 7,157
The description of membrane lipid conformation, order and dynamics by 2H-NMR
Davis, J. H. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90015-1 · Cited by 1,017
Cholesterol and the Golgi Apparatus
Bretscher, M. S., & Munro, S. (1993) · Science · doi:10.1126/science.8362242 · Cited by 819
London, E., & Brown, D. A. (2000) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0304-4157(00)00007-1 · Cited by 688
Brown, D. A., & London, E. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7575 · Cited by 517
The concept of lipid domains in membranes.
Karnovsky, M. J., Kleinfeld, A. M., Hoover, R. L., & Klausner, R. D. (1982) · The Journal of cell biology · doi:10.1083/jcb.94.1.1 · Cited by 469
Condensed complexes of cholesterol and phospholipids
McConnell, H. M., & Radhakrishnan, A. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00015-4 · Cited by 384
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Metadata
- Authors
- Recktenwald, D. J., & McConnell, H. M.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1981-07-21
- Volume
- 20
- Issue
- 15
- Pages
- 4505-4510
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2072033208
- Cited by
- 244
- References
- 0
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- closed
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