The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Antigenicity of elastin: characterization of major antigenic determinants on purified insoluble elastin
Abstract
This investigation reports a systematic comparison of antibody responses to well-defined fragments of mature, insoluble elastin in order to identify antigenic regions of the molecule. Antiserum to insoluble elastin was used to screen by radioimmunoassay the serologic activity of elastin peptides purified from a thermolysin digestion of insoluble elastin. Fractions with positive antigenicity were characterized by amino acid analysis and protein sequence analysis. Our results indicate that antigenic determinants on elastin can be classified functionally into two categories: major determinants related to the cross-linking domain which show cross-reactivity between species and limited, species-specific determinants in non-cross-linked regions of the molecule.
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“Elastin denaturation during the decellularization may also produce elastin particles with significant antigenicity [115].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [115]
Citations
Cites
Molecular Model for Elastin Structure and Function
GRAY, W. R., SANDBERG, L. B., & FOSTER, J. A. (1973) · Nature · doi:10.1038/246461a0 · Cited by 405
Purification and comparison of elastins from different animal species
STARCHER, B. C., & Galione, M. J. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90224-4 · Cited by 187
Radioimmunoassay for Desmosine
King, G. S., Mohan, V. S., & STARCHER, B. C. (1980) · Connective Tissue Research · doi:10.3109/03008208009152362 · Cited by 103
Isolation and Characterization of CrossLinked Peptides from Elastin
Foster, J. A., Rubin, L., Kagan, H. M., Franzblau, C., Bruenger, E., & Sandberg, L. B. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42239-4 · Cited by 101
Studies on the Conformation and Interactions of Elastin
Urry, D. W. (1974) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-3243-5_11 · Cited by 67
Circular dichroism studies of an elastin crosslinked peptide
Foster, J. A., Bruenger, E., Rubin, L., Imberman, M., Kagan, H. M., Mecham, R. P., & Franzblau, C. (1976) · Biopolymers · doi:10.1002/bip.1976.360150503 · Cited by 47
Self-citationTryptic Peptides from the Cross-Linking Regions of Insoluble Calf Skin Collagen
Becker, U., Furthmayr, H., & Timpl, R. (1975) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1975.356.1.21 · Cited by 47
A structural model for desmosine cross-linked peptides
Mecham, R. P., & Foster, J. A. (1978) · Biochemical Journal · doi:10.1042/bj1730617 · Cited by 38
Self-citationArterial mesenchyme and arteriosclerosis. Studies on the conformation and interaction of elastin.
Urry, D. W. (1974) · PubMed · Cited by 37
Jackson, D. S., Sandberg, L. B., & CLEARY, E. G. (1966) · Nature · doi:10.1038/210195a0 · Cited by 27
Measurement by Radioimmunoassay of Soluble Elastins from Different Animal Species
Mecham, R. P., & Lange, G. W. (1980) · Connective Tissue Research · doi:10.3109/03008208009152360 · Cited by 27
Self-citationAn Analysis of the Organ and Species Immunospecificity of Elastin
Kucich, U., Christner, P. J., Rosenbloom, J., & Weinbaum, G. (1981) · Connective Tissue Research · doi:10.3109/03008208109152131 · Cited by 17
Chidlow, J. W., Bourne, F. J., & Bailey, A. J. (1974) · PubMed Central · Cited by 13
Houle, D., & Lacbella, F. (1977) · Connective Tissue Research · doi:10.3109/03008207709152234 · Cited by 12
Chemical characterization of α-elastin components
Abatangelo, G., Cortivo, R., Daga-Gordini, D., & Garbin, G. (1974) · Biochimica et Biophysica Acta (BBA) - Protein Structure · doi:10.1016/0005-2795(74)90255-4 · Cited by 5
Cited by
Elastomeric biomaterials for tissue engineering
Chen, Q., Liang, S., & Thouas, G. A. (2013) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.05.003 · Cited by 564
Elastin as a biomaterial for tissue engineering
Daamen, W. F., Veerkamp, J. H., van Hest, J. C. M., & van Kuppevelt, T. H. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.06.025 · Cited by 518
Senior, R. M., Griffin, G. L., Mecham, R. P., Wrenn, D. S., Prasad, K. U., & Urry, D. W. (1984) · The Journal of cell biology · doi:10.1083/jcb.99.3.870 · Cited by 408
Self-citationKasravi, M., Ahmadi, A., Babajani, A., Mazloomnejad, R., Hatamnejad, M. R., Shariatzadeh, S., Bahrami, S., & Niknejad, H. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00348-z · Cited by 316
Isolated osteoclasts resorb the organic and inorganic components of bone.
Blair, H. C., Kahn, A. J., Crouch, E. C., Jeffrey, J. J., & Teitelbaum, S. L. (1986) · The Journal of cell biology · doi:10.1083/jcb.102.4.1164 · Cited by 282
Metadata
- Authors
- Mecham, R. P., & Lange, G.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Mecham, Robert P.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1982-02-16
- Volume
- 21
- Issue
- 4
- Pages
- 669-673
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2007829335
- Cited by
- 57
- References
- 15
- Citations by year
- 2025: 1 · 2023: 4 · 2017: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Keywords
- elastin, antigenic determinants, antibody response, cross-species reactivity, species-specific epitopes, thermolysin digestion, elastin peptides, epitope mapping
- MeSH terms
- Animals, Antibody Specificity, Epitopes, Cattle, Elastin, Peptide Fragments, Protein Conformation, Rabbits, Species Specificity
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
