The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Novel Antisense and Peptide Nucleic Acid Strategies for Controlling Gene Expression
Abstract
Antisense oligonucleotides have the potential to make revolutionary contributions to basic science and medicine. Oligonucleotides can bind mRNA and inhibit translation. Because they can be rapidly synthesized to be complementary to any sequence, they offer ideal tools for exploiting the massive amount of genome information now available. However, until recently, this potential was largely theoretical, and antisense experiments often produced inconclusive or misleading outcomes. This review will discuss the chemical and biological properties of some of the different types of oligomers now available and describe the challenges confronting in vitro and in vivo use of oligonucleotides. Oligomers with improved chemical properties, combined with advances in cell biology and success in clinical trials, are affording powerful new options for basic research, biotechnology, and medicine.
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Citations
Cites
Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide
Nielsen, P. E., Egholm, M., Berg, R. H., & Buchardt, O. (1991) · Science · doi:10.1126/science.1962210 · Cited by 3,332
PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
Egholm, M., Buchardt, O., Christensen, L., Behrens, C., Freier, S. M., Driver, D. A., Berg, R. H., Kim, S. K., Norden, B., & Nielsen, P. E. (1993) · Nature · doi:10.1038/365566a0 · Cited by 2,079
Keeping the biotechnology of antisense in context
Stein, C. A. (1999) · Nature Biotechnology · doi:10.1038/6909 · Cited by 68
Cited by
siRNAs: applications in functional genomics and potential as therapeutics
Dorsett, Y., & Tuschl, T. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1345 · Cited by 909
siRNA-based approaches in cancer therapy
Devi, G. R. (2006) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700931 · Cited by 353
Asanuma, H., Liang, X., Nishioka, H., Matsunaga, D., Liu, M., & Komiyama, M. (2007) · Nature Protocols · doi:10.1038/nprot.2006.465 · Cited by 311
Positional Effect of Chemical Modifications on Short Interference RNA Activity in Mammalian Cells
Prakash, T. P., Allerson, C. R., Dande, P., Vickers, T. A., Sioufi, N., Jarres, R., Baker, B. F., Swayze, E. E., Griffey, R. H., & Bhat, B. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050044o · Cited by 285
Metadata
- Authors
- Braasch, D. A., & Corey, D. R.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-03-09
- Volume
- 41
- Issue
- 14
- Pages
- 4503-4510
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2166765502
- Cited by
- 248
- References
- 3
- FWCI
- 11.77
- Type
- journal article
- Language
- en
- Open access
- closed
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