Self-Assembly of Aβ 1 - 42 into Globular Neurotoxins

Cited by (518)

Items 201–300 of 518

1. Toxicity mediated by soluble oligomers of β‐amyloid(1–42) on cholinergic SN56.B5.G4 cells
   Katrin Heinitz, Martin Beck, Reinhard Schliebs, Jose Regino Perez-Polo · 2006 · Journal of Neurochemistry
2. The link between cholesterol and Alzheimer's disease
   M. Sjögren, K. Blennow · 2005 · World Journal of Biological Psychiatry
3. Exploration of the mechanism for LPFFD inhibiting the formation of β-sheet conformation of Aβ(1–42) in water
   Yang Cao, Xiaolei Zhu, Jinyu Li, Rongwei Shi · 2010 · Journal of Molecular Modeling
4. Calcium dyshomeostasis and neurotoxicity of Alzheimer’s β-amyloid protein
   Masahiro Kawahara, Midori Kato‐Negishi, Yutaka Sadakane · 2009 · Expert Review of Neurotherapeutics
5. Synapse-Binding Subpopulations of Aβ Oligomers Sensitive to Peptide Assembly Blockers and scFv Antibodies
   Pauline T. Velasco, Marie C. Heffern, Adriano Silva Sebollela, Izolda A. Popova, Pascale N. Lacor, Kevin B. Lee, Xiaoxia Sun, Benjamin N. Tiano, Kirsten L. Viola, Amanda L. Eckermann et al. · 2012 · ACS Chemical Neuroscience
6. Polyphenolic Glycosides and Aglycones Utilize Opposing Pathways To Selectively Remodel and Inactivate Toxic Oligomers of Amyloid β
   Ali Reza A. Ladiwala, Mauricio Mora‐Pale, Jason Ching‐Yao Lin, Shyam Sundhar Bale, Zachary S. Fishman, Jonathan S. Dordick, Peter M. Tessier · 2011 · ChemBioChem
7. Oxytocin attenuates microglial activation and restores social and non-social memory in APP/PS1 Alzheimer model mice
   María Clara Sellés, Juliana T.S. Fortuna, Yasmin P.R. de Faria, Luciana Domett Siqueira, Ricardo A. S. Lima‐Filho, Beatriz M. Longo, Robert C. Froemke, Moses V. Chao, Sergio Teixeira Ferreira · 2023 · iScience
8. Nanoparticle assisted magnetic resonance imaging of the early reversible stages of amyloid β self-assembly
   Jin‐sil Choi, Hyuck Jae Choi, Dae Chul Jung, Joo-Hyuk Lee, Jinwoo Cheon · 2008 · Chemical Communications
9. Anti-Amnesic and Neuroprotective Actions of the Sigma-1 Receptor Agonist (-)-MR22 in Rats with Selective Cholinergic Lesion and Amyloid Infusion
   Vuokko Antonini, Agostino Marrazzo, Giulio Kleiner, Marino Coradazzi, Simone Ronsisvalle, Orazio Prezzavento, Giuseppe Ronsisvalle, Giampiero Leanza · 2011 · Journal of Alzheimer s Disease
10. Anti-amyloidogenic property of leaf aqueous extract of Caesalpinia crista
    Balenahalli Narasingappa Ramesh, Shantinath Satappa Indi, K. S. Jagannatha Rao · 2010 · Neuroscience Letters
11. Functional characterization of α7 nicotinic acetylcholine and NMDA receptor signaling in SH-SY5Y neuroblastoma cells in an ERK phosphorylation assay
    Mohamed R. Elnagar, Anne B. Walls, Gouda Kamel Helal, Farid M.A. Hamada, Morten Skøtt Thomsen, Anders A. Jensen · 2018 · European Journal of Pharmacology
12. ACU193: An Immunotherapeutic Poised to Test the Amyloid β Oligomer Hypothesis of Alzheimer’s Disease
    Grant A. Krafft, Jasna Jerecı̀ć, Eric Siemers, Erika N. Cline · 2022 · Frontiers in Neuroscience
13. Expression and Localization of Mitochondrial Ferritin mRNA in Alzheimer's Disease Cerebral Cortex
    Ligang Wang, Hongkuan Yang, Shiguang Zhao, Haruhisa Sato, Yoshihiro Konishi, Thomas G. Beach, Essam Mohamed Abdelalim, Naomi J. Bisem, Ikuo Tooyama · 2011 · PLoS ONE
14. The Cu(II)/Aβ/Human Serum Albumin Model of Control Mechanism for Copper-Related Amyloid Neurotoxicity
    Małgorzata Rózga, Wojciech Bal · 2009 · Chemical Research in Toxicology
15. Aggregation of amyloids in a cellular context: modelling and experiment
    Ran Friedman · 2011 · Biochemical Journal
16. Disordered Proteins: Biological Membranes as Two-Dimensional Aggregation Matrices
    Roberth Byström, Christopher Aisenbrey, Tomasz Borowik, Marcus Bokvist, Fredrick Lindström, Marc‐Antoine Sani, Anders Olofsson, Gerhard Gröbner · 2008 · Cell Biochemistry and Biophysics
17. Subtype‐specific actions of β‐amyloid peptides on recombinant human neuronal nicotinic acetylcholine receptors (α7, α4β2, α3β4) expressed in Xenopus laevis oocytes
    Luanda J. Pym, Mark Kemp, Valérie Raymond, Steven David Buckingham, C.A.R. Boyd, David Barry Sattelle · 2005 · British Journal of Pharmacology
18. Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases
    Limbocker, Ryan, Cremades, Nunilo, Cascella, Roberta, Tessier, Peter M., Vendruscolo, Michele, Chiti, Fabrizio · 2023 · Accounts of Chemical Research
19. Development and validation of a yeast high-throughput screen for inhibitors of Aβ42 oligomerization
    Sei-Kyoung Park, Scott D. Pegan, Andrew D. Mesecar, Lisa M. Jungbauer, Mary Jo LaDu, Susan Weiss Liebman · 2011 · Disease Models & Mechanisms
20. Controlled in situ preparation of Aβ(1–42) oligomers from the isopeptide “iso-Aβ(1–42)”, physicochemical and biological characterization
    Zsolt Bozsó, Botond Penke, Dóra Simon, Ilona Laczkó, Gábor Juhász, Viktor Szegedi, Ágnes Kasza, Katalin Soós, Anasztázia Hetényi, Edit Wéber et al. · 2009 · Peptides
21. Small heat shock proteins differentially affect Aβ aggregation and toxicity
    Sungmun Lee, Kenneth H. Carson, Allison C. Rice‐Ficht, Theresa A. Good · 2006 · Biochemical and Biophysical Research Communications
22. Solution NMR Studies of Recombinant Aβ(1–42): From the Presence of a Micellar Entity to Residual β‐Sheet Structure in the Soluble Species
    Marielle Aulikki Wälti, Julien Orts, Beat Vögeli, Silvia Campioni, Roland Riek · 2015 · ChemBioChem
23. Amyloid beta1–42 (Aβ42) up‐regulates the expression of sortilin via the p75 NTR /RhoA signaling pathway
    Khalil Saadipour, Miao Yang, Yoon Pin Lim, Kristen R. Georgiou, Ying Sun, Damien J. Keating, Jia Liu, Ye‐Ran Wang, Wei‐Ping Gai, Jinhua Zhong et al. · 2013 · Journal of Neurochemistry
24. Ganglioside‐mediated aggregation of amyloid β‐proteins (Aβ): comparison between Aβ‐(1–42) and Aβ‐(1–40)
    Mariko Ogawa, Miho Tsukuda, Takahiro J. YAMAGUCHI, Keisuke Ikeda, Takuma Okada, Yoshiaki Yano, Masaru Hoshino, Katsumi Matsuzaki · 2010 · Journal of Neurochemistry
25. Direct electrochemical and AFM detection of amyloid-β peptide aggregation on basal plane HOPG
    Paula Lopes, Meng Xu, Min Zhang, Ting Zhou, Yanlian Yang, Chen Wang, Elena E. Ferapontova · 2014 · Nanoscale
26. Biophysical Comparison of Soluble Amyloid-β(1–42) Protofibrils, Oligomers, and Protofilaments
    Michael R. Nichols, Benjamin A. Colvin, Elizabeth A. Hood, Geeta S. Paranjape, David C. Osborn, Shana E. Terrill · 2015 · Biochemistry
27. Neuronal and Axonal Loss Are Selectively Linked to Fibrillar Amyloid-β within Plaques of the Aged Primate Cerebral Cortex
    Palak Shah, Neeta Lal, Elaine Leung, David Traul, A. Gonzalo‐Ruiz, Changiz Geula · 2010 · American Journal Of Pathology
28. Alzheimer's disease-associated peptide Aβ42 mobilizes ER Ca2+ via InsP3R-dependent and -independent mechanisms
    Laura E. Jensen, Geert Bultynck, Tomas Luyten, Hozeefa Amijee, Martin D. Bootman, H. Llewelyn Roderick · 2013 · Frontiers in Molecular Neuroscience
29. The Role of β-Amyloid Protein in Synaptic Function: Implications for Alzheimers Disease Therapy
    Fernando Peña‐Ortega, Armando I. Gutiérrez-Lerma, Ricardo Quiroz‐Baez, Clorinda Arias · 2006 · Current Neuropharmacology
30. Biflavonoids as Potential Small Molecule Therapeutics for Alzheimer’s Disease
    Arjun Thapa, Eva Y. Chi · 2015 · Advances in experimental medicine and biology
31. Characterization of Homogeneous and Heterogeneous Amyloid-β42 Oligomer Preparations with Biochemical Methods and Infrared Spectroscopy Reveals a Correlation between Infrared Spectrum and Oligomer Size
    F. Vosough, A. Barth · 2021 · ACS Chemical Neuroscience
32. A Strategy for Designing a Peptide Probe for Detection of β‐Amyloid Oligomers
    Yang Hu, Baihao Su, Chung‐Sei Kim, Michael X. Hernandez, Agueda A. Rostagno, Jorge A. Ghiso, Jin Ryoun Kim · 2010 · ChemBioChem
33. Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process
    Garima Thakur, Miodrag Mićić, Yuehai Yang, Wenzhi Li, Dania Movia, Silvia Giordani, Hongzhou Zhang, Roger M. Leblanc · 2011 · International Journal of Alzheimer s Disease
34. Activation of α7 nicotinic acetylcholine receptor alleviates Aβ1-42-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways
    Ke-Wei Chang, Hang-Fan Zong, Kaige Ma, Wan-Ying Zhai, Weina Yang, Xiaodan Hu, Jiehua Xu, Xinlin Chen, Shengfeng Ji, Yi‐Hua Qian · 2018 · Neurochemistry International
35. Novel demonstration of amyloid-β oligomers in sporadic inclusion-body myositis muscle fibers
    Anna Nogalska, Carla D’Agostino, W. King Engel, William L. Klein, Valerie Askanas · 2010 · Acta Neuropathologica
36. Alzheimer’s Disease and Protein Kinases
    Ayşe Başak Engin, Atilla Engin · 2021 · Advances in experimental medicine and biology
37. Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?
    Rudy J. Castellani, Xiongwei Zhu, Hyoung‐gon Lee, Paula Isabel Moreira, George L. Perry, Mark A. Smith · 2007 · Expert Review of Neurotherapeutics
38. Hierarchical self-assembly of a β-amyloid peptide derivative
    Si‐Yong Qin, Yi Pei, Xiangji Liu, Ren‐Xi Zhuo, Xian‐Zheng Zhang · 2012 · Journal of Materials Chemistry B
39. Mechanism of Fibril Formation by a 39-Residue Peptide (PAPf39) from Human Prostatic Acidic Phosphatase
    Zhuqiu Ye, Kinsley C. French, Ludmila A. Popova, Igor K. Lednev, María M. López, George I. Makhatadze · 2009 · Biochemistry
40. Formation of Toxic Amyloid Fibrils by Amyloid β‐Protein on Ganglioside Clusters
    Katsumi Matsuzaki · 2011 · International Journal of Alzheimer s Disease
41. Microglia activation mediates fibrillar amyloid-β toxicity in the aged primate cortex
    Elaine Leung, Ling Guo, Jing Bu, Marie E. Maloof, Joseph B. El Khoury, Changiz Geula · 2009 · Neurobiology of Aging
42. The effect of solvents on the conformations of Amyloid β-peptide (1–42) studied by molecular dynamics simulation
    Yang Cao, Jinyu Li, Yu Li, Xiaolei Zhu · 2008 · Journal of Molecular Structure THEOCHEM
43. Phospholipase A2 inhibitors protect against prion and Aβ mediated synapse degeneration
    Clive Bate, Mourad Tayebi, Alun Williams · 2010 · Molecular Neurodegeneration
44. Aβ peptide conformation determines uptake and interleukin-1α expression by primary microglial cells
    Saravanapavan Parvathy, Jayakumar Rajadas, Heather S. Ryan, Sepideh Vaziri, Laurel Anderson, Greer M. Murphy · 2008 · Neurobiology of Aging
45. Out-of-Register Parallel β-Sheets and Antiparallel β-Sheets Coexist in 150-kDa Oligomers Formed by Amyloid-β(1–42)
    Yuan Gao, Cong Guo, Jens O. Watzlawik, Peter S. Randolph, Elizabeth J. Lee, Danting Huang, Scott M. Stagg, Huan‐Xiang Zhou, Terrone L. Rosenberry, Anant K. Paravastu · 2020 · Journal of Molecular Biology
46. Effects of Peptides Derived from Terminal Modifications of the Aβ Central Hydrophobic Core on Aβ Fibrillization
    Cyrus K. Bett, Wilson K. Serem, Krystal R. Fontenot, Robert P. Hammer, Jayne C. Garno · 2010 · ACS Chemical Neuroscience
47. Advances on the Understanding of the Origins of Synaptic Pathology in AD
    Pascale N. Lacor · 2007 · Current Genomics
48. Modulation of Amyloid β Peptide1-42 Cytotoxicity and Aggregation in Vitro by Glucose and Chondroitin Sulfate
    Xavier Fernàndez‐Busquets, Jovita Ponce, R. Bravo, Muriel Arimon, Tània Martiáñez, Alejandro Gella, Josep Cladera, N. Durany · 2010 · Current Alzheimer Research
49. In vitroOligomerization and Fibrillogenesis of Amyloid-beta Peptides
    Núria Benseny‐Cases, Oksana Klementieva, Josep Cladera · 2012 · Sub-cellular biochemistry/Subcellular biochemistry
50. Size-Dependent Interaction of Amyloid β Oligomers with Brain Total Lipid Extract Bilayer─Fibrillation Versus Membrane Destruction
    Dušan Mrđenović, Marta Majewska, Izabela S. Pieta, Piotr Bernatowicz, Robert Nowakowski, Włodzimierz Kutner, Jacek Lipkowski, Piotr Pięta · 2019 · Langmuir
51. Protofibril–Fibril Interactions Inhibit Amyloid Fibril Assembly by Obstructing Secondary Nucleation
    Filip Hasecke, Chamani Niyangoda, Gustavo J. Borjas, Jianjun Pan, Garrett Matthews, Martin Muschol, Wolfgang Hoyer · 2020 · Angewandte Chemie International Edition
52. Long-term depression links amyloid-β to the pathological hyperphosphorylation of tau
    Henry B. C. Taylor, Nigel J. Emptage, Alexander F. Jeans · 2021 · Cell Reports
53. Axon degeneration is key component of neuronal death in amyloid-β toxicity
    Wilson Mawutor Alobuia, Wei Xia, Bhupinder P. S. Vohra · 2013 · Neurochemistry International
54. Computer Simulations of Alzheimers Amyloid β-Protein Folding and Assembly
    Brigita Urbanc, Luis Cruz, David B. Teplow, Eugene Stanley · 2006 · Current Alzheimer Research
55. Binding of Thioflavin T and Related Probes to Polymorphic Models of Amyloid-β Fibrils
    Francesca Peccati, Stefano Pantaleone, Vanessa Riffet, Xavier Solans‐Monfort, Julia Contreras‐García, Vı́ctor Guallar, Mariona Sodupe · 2017 · The Journal of Physical Chemistry B
56. Protective effects of tanshinone IIA on SH-SY5Y cells against oAβ1–42-induced apoptosis due to prevention of endoplasmic reticulum stress
    Weina Yang, Jianshui Zhang, Lili Shi, Shengfeng Ji, Xiaohua Yang, Wanying Zhai, Hang-Fan Zong, Yi‐Hua Qian · 2018 · The International Journal of Biochemistry & Cell Biology
57. A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid‐β oligomers
    Adriano Silva Sebollela, Erika N. Cline, Izolda A. Popova, Kevin Luo, Xiaoxia Sun, Jay Ahn, Milena A. Barcelos, Vanessa N. Bezerra, Natalia M. Lyra e Silva, Jason Patel et al. · 2017 · Journal of Neurochemistry
58. Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer’s-Associated Aβ Oligomers
    Kyle C. Wilcox, Matthew R. Marunde, Aditi Das, Pauline T. Velasco, Benjamin D. Kuhns, Michael Thomas Marty, Jiang Haoming, Chi-Hao Luan, Stephen G. Sligar, William L. Klein · 2015 · PLoS ONE
59. X-ray Crystallographic Structures of Oligomers of Peptides Derived from β2-Microglobulin
    Ryan K. Spencer, Adam G. Kreutzer, Patrick J. Salveson, Hao Li, James S. Nowick · 2015 · Journal of the American Chemical Society
60. Kinetic studies of inhibition of the amyloid beta (1–42) aggregation using a ferrocene-tagged β-sheet breaker peptide
    Lin Zhang, Gargey B. Yagnik, Yong Peng, Jianxiu Wang, H. Howard Xu, Yuanqiang Hao, You‐Nian Liu, Feimeng Zhou · 2012 · Analytical Biochemistry
61. Increased BACE1 mRNA and noncoding BACE1-antisense transcript in sporadic inclusion-body myositis muscle fibers—Possibly caused by endoplasmic reticulum stress
    Anna Nogalska, W. King Engel, Valerie Askanas · 2010 · Neuroscience Letters
62. Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouse
    Ayumi Takamura, Yasuhide Okamoto, Takeshi Kawarabayashi, Tatsuki Yokoseki, Masao Suzuki Shibata, Akihiro Mouri, Toshitaka Nabeshima, Hui Sun, Koji Abe, Tsuneo Urisu et al. · 2011 · Molecular Neurodegeneration
63. AAV-mediated neuronal expression of an scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models
    María Clara Sellés, Juliana T.S. Fortuna, Magalí Cecilia Cercato, Luís E. Santos, Luciana Domett, Andre L.B. Bitencourt, Mariane Favero Carraro, Amanda Santos de Souza, Helena Janíčková, Caroline Vieira Azevedo et al. · 2022 · Molecular Therapy
64. Sortilin is required for toxic action of Aβ oligomers (AβOs): Extracellular AβOs trigger apoptosis, and intraneuronal AβOs impair degradation pathways
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65. Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer’s disease-associated Aβ oligomers
    Niele Dias Mendes, Artur Fernandes, Glaucia Maria de Almeida, Luís E. Santos, María Clara Sellés, Natalia M. Lyra e Silva, Carla de Moraes Machado, José de Anchieta C. Horta‐Júnior, Paulo Roberto Louzada, Fernanda G. De Felice et al. · 2018 · Journal of Neuroscience Methods
66. Restoration of impaired phosphorylation of cyclic AMP response element‐binding protein (CREB) by EGb 761 and its constituents in Aβ‐expressing neuroblastoma cells
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67. Hexafluoroisopropanol induces self‐assembly of β‐amyloid peptides into highly ordered nanostructures
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68. Soluble amyloid β oligomers may contribute to apoptosis of retinal ganglion cells in glaucoma
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69. A unifying framework for amyloid-mediated membrane damage: The lipid-chaperone hypothesis
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70. Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains
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71. Decreased nicotinic receptors and cognitive deficit in rats intracerebroventricularly injected with beta‐amyloid peptide(1‐42) and fed a high‐cholesterol diet
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72. The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia
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73. Methionine oxidation reduces lag-times for amyloid-β(1–40) fiber formation but generates highly fragmented fibers
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74. Pseudoginsenoside‐F11 alleviates oligomeric β‐amyloid‐induced endosome‐lysosome defects in microglia
    Xue Yao, Xue Xue, Hao T. Zhang, Ming Zhu, Xiao W. Yang, Chun Fu Wu, Jingyu Yang · 2018 · Traffic
75. Ex Situ Atomic Force Microscopy Analysis of β-Amyloid Self-Assembly and Deposition on a Synthetic Template
    Chanki Ha, Chan Beum Park · 2006 · Langmuir
76. Dopamine release in prefrontal cortex in response to β-amyloid activation of α7∗ nicotinic receptors
    Jian‐Lin Wu, Ghous M. Khan, Robert A. Nichols · 2007 · Brain Research
77. Amyloid-β E22Δ variant induces synaptic alteration in mouse hippocampal slices
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78. Polymorphism of Oligomers of a Peptide from β-Amyloid
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79. Breaking the Code of Amyloid- β Oligomers
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80. KLVFF peptide functionalized nanoparticles capture Aβ42 by co-assembly for decreasing cytotoxicity
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81. Amyloid-β peptide binds to microtubule-associated protein 1B (MAP1B)
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82. Real-Time Analysis of Binding Events between Different Aβ_1–42 Species and Human Lilrb2 by Dual Polarization Interferometry
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83. Expression of a Familial Alzheimer's Disease-Linked Presenilin-1 Variant Enhances Perforant Pathway Lesion-Induced Neuronal Loss in the Entorhinal Cortex
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84. Age-related calcium changes, oxyradical damage, caspase activation and nuclear condensation in hippocampal neurons in response to glutamate and beta-amyloid
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85. Characterization of Early Stage Intermediates in the Nucleation Phase of Aβ Aggregation
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86. A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-β
    Reinke, Ashley A., Seh, Han Yiau, Gestwicki, Jason E. · 2009 · Bioorganic & Medicinal Chemistry Letters
87. Key residues for the oligomerization of Aβ42 protein in Alzheimer’s disease
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88. Acute amnestic encephalopathy in amyloid-β oligomer–injected mice is due to their widespread diffusion in vivo
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89. Oligomeric Aβ-Induced Microglial Activation is Possibly Mediated by NADPH Oxidase
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90. Differential Regulation of N-Methyl-D-Aspartate Receptor Subunits is An Early Event in the Actions of Soluble Amyloid-β1-40 Oligomers on Hippocampal Neurons
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91. Dimebon alters hippocampal amyloid pathology in 3xTg-AD mice.
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92. Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide
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93. Unveiling the Potential of Polyphenols as Anti-Amyloid Molecules in Alzheimer’s Disease
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94. β-amyloid oligomers and prion protein
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95. Self-Propagative Replication of Aβ Oligomers Suggests Potential Transmissibility in Alzheimer Disease
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96. Role of Small Oligomers on the Amyloidogenic Aggregation Free-Energy Landscape
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97. Computer Simulation Studies of Aβ 37–42 Aggregation Thermodynamics and Kinetics in Water and Salt Solution
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98. Methods and models in neurodegenerative and systemic protein aggregation diseases.
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99. Isorhamnetin Attenuated the Release of Interleukin‐6 from β‐Amyloid‐Activated Microglia and Mitigated Interleukin‐6‐Mediated Neurotoxicity
    Pei‐Cih Wei, Guey‐Jen Lee‐Chen, Chiung‐Mei Chen, Ying Chen, Yen‐Shi Lo, Kuo‐Hsuan Chang · 2022 · Oxidative Medicine and Cellular Longevity
100. ACU193, a Monoclonal Antibody that Selectively Binds Soluble Aβ Oligomers: Development Rationale, Phase 1 Trial Design, and Clinical Development Plan
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