Self-Assembly of Aβ 1 - 42 into Globular Neurotoxins

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Items 101–200 of 518

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   Cheng-Ning Yang, Y. Shiao, F. Shie, Bo-Shen Guo, Pei-Hao Chen, C. Cho, Yi-Jen Chen, Fong-Lee Huang, H. Tsay · 2011 · Neurobiology of Disease
2. GM1 ganglioside-mediated accumulation of amyloid β-protein on cell membranes
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3. Alzheimer’s β-peptide oligomer formation at physiologic concentrations
   Harry LeVine · 2004 · Analytical Biochemistry
4. A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease
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5. Alzheimer's Disease and the Amyloid β-Protein
   Dominic M. Walsh, David B. Teplow · 2012 · Progress in molecular biology and translational science
6. β-Azidoalanine as an IR Probe: Application to Amyloid Aβ(16-22) Aggregation
   Kwang‐Im Oh, Joohyun Lee, Cheonik Joo, Hogyu Han, Minhaeng Cho · 2008 · The Journal of Physical Chemistry B
7. Stimulation of PGE2 receptors EP2 and EP4 protects cultured neurons against oxidative stress and cell death following β‐amyloid exposure
   Valentina Echeverrı́a, Andrew Clerman, Sylvain Doré · 2005 · European Journal of Neuroscience
8. β-Amyloid Stimulates Murine Postnatal and Adult Microglia Cultures in a Unique Manner
   Floden, Angela M., Combs, Colin K. · 2006 · The Journal of Neuroscience
9. Protein aggregation, metals and oxidative stress in neurodegenerative diseases
   B.J. Tabner, O.M.A. El-Agnaf, Matthew J. German, Nigel J. Fullwood, David Allsop · 2005 · Biochemical Society Transactions
10. Successive Stages of Amyloid-β Self-Assembly Characterized by Solid-State Nuclear Magnetic Resonance with Dynamic Nuclear Polarization
    Alexey Potapov, Wai‐Ming Yau, Rodolfo Ghirlando, Kent R. Thurber, Robert Tycko · 2015 · Journal of the American Chemical Society
11. Formation of Toxic Aβ(1–40) Fibrils on GM1 Ganglioside-Containing Membranes Mimicking Lipid Rafts: Polymorphisms in Aβ(1–40) Fibrils
    Takuma Okada, Keisuke Ikeda, Masaki Wakabayashi, Mariko Ogawa, Katsumi Matsuzaki · 2008 · Journal of Molecular Biology
12. Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases
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13. Aggregation Pathways of the Amyloid β(1–42) Peptide Depend on Its Colloidal Stability and Ordered β-Sheet Stacking
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14. Understanding the Molecular Basis for the Inhibition of the Alzheimer's Aβ-Peptide Oligomerization by Human Serum Albumin Using Saturation Transfer Difference and Off-Resonance Relaxation NMR Spectroscopy
    Julijana Milojevic, Veronica Esposito, Rahul Das, Giuseppe Melacini · 2007 · Journal of the American Chemical Society
15. Formation of Toxic Fibrils of Alzheimer’s Amyloid β-Protein-(1–40) by Monosialoganglioside GM1, a Neuronal Membrane Component
    Takuma Okada, Masaki Wakabayashi, Keisuke Ikeda, Katsumi Matsuzaki · 2007 · Journal of Molecular Biology
16. Conversion of non-fibrillar β-sheet oligomers into amyloid fibrils in Alzheimer’s disease amyloid peptide aggregation
    Núria Benseny‐Cases, M. Cócera, Josep Cladera · 2007 · Biochemical and Biophysical Research Communications
17. ADDLs and the signaling web that leads to Alzheimer’s disease
    Grant A. Krafft, William L. Klein · 2010 · Neuropharmacology
18. Polyphenols as Therapeutic Molecules in Alzheimer’s Disease Through Modulating Amyloid Pathways
    Johant Lakey‐Beitia, Ruben Berrocal, K. S. Jagannatha Rao, Armando A. Durant-Archibold · 2014 · Molecular Neurobiology
19. Oligomer-specific Aβ toxicity in cell models is mediated by selective uptake
    Sidhartha M. Chafekar, Frank Baas, Wiep Scheper · 2008 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
20. Evidence of Aβ‐ and transgene‐dependent defects in ERK‐CREB signaling in Alzheimer’s models
    Qiu‐Lan Ma, Marni E. Harris‐White, Oliver J. Ubeda, Mychica Simmons, Walter K. Beech, Giselle P. Lim, Bruce Teter, Sally Ann Frautschy, Greg M. Cole · 2007 · Journal of Neurochemistry
21. β-Amyloid Fibrils in Alzheimer Disease Are Not Inert When Bound to Copper Ions but Can Degrade Hydrogen Peroxide and Generate Reactive Oxygen Species
    Jennifer Mayes, Claire L. Tinker, Oleg Kolosov, Hao Zhang, Brian J. Tabner, David Allsop · 2014 · Journal of Biological Chemistry
22. Synaptic targeting by Aβ oligomers (ADDLS) as a basis for memory loss in early Alzheimer's disease
    William L. Klein · 2006 · Alzheimer s & Dementia
23. Antibodies against β‐amyloid reduce aβ oligomers, glycogen synthase kinase‐3β activation and τ phosphorylation in vivo and in vitro
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24. Ribosylation Rapidly Induces α-Synuclein to Form Highly Cytotoxic Molten Globules of Advanced Glycation End Products
    Lan Chen, Wei Yan, Xueqing Wang, Rongqiao He · 2010 · PLoS ONE
25. Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity
    Fuxiang Bao, Linn Wicklund, Pascale N. Lacor, William L. Klein, Agneta K. Nordberg, Amelia Marutle · 2011 · Neurobiology of Aging
26. Ion Mobility Separation Coupled with MS Detects Two Structural States of Alzheimer's Disease Aβ1–40 Peptide Oligomers
    Marcin Kłoniecki, Agnieszka Jabłonowska, Jarosław T. Poznański, James Langridge, Chris J. Hughes, Iain D. G. Campuzano, Kevin Giles, Michał Dadlez · 2011 · Journal of Molecular Biology
27. Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Aβ fibril formation pathway
    Sungmun Lee, Erik Fernández, Theresa A. Good · 2007 · Protein Science
28. Small molecule inhibitors of Aβ‐aggregation and neurotoxicity
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29. Cellular Polyamines Promote Amyloid-Beta (Aβ) Peptide Fibrillation and Modulate the Aggregation Pathways
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30. Biflavonoids Are Superior to Monoflavonoids in Inhibiting Amyloid-β Toxicity and Fibrillogenesis via Accumulation of Nontoxic Oligomer-like Structures
    Arjun Thapa, Eun‐Rhan Woo, Eva Y. Chi, Md Golam Sharoar, Hong-Guang Jin, Song Yub Shin, Il‐Seon Park · 2011 · Biochemistry
31. Enhanced Toxicity and Cellular Binding of a Modified Amyloid β Peptide with a Methionine to Valine Substitution
    Giuseppe D. Ciccotosto, Deborah J. Tew, Cyril C. Curtain, Danielle Smith, Darryl Carrington, Colin Louis Masters, Ashley Ian Bush, Robert A. Cherny, Roberto Cappai, Kevin Jeffrey Barnham · 2004 · Journal of Biological Chemistry
32. Cytokine-Mediated Inhibition of Fibrillar Amyloid-β Peptide Degradation by Human Mononuclear Phagocytes
    Yamamoto, Masaru, Kiyota, Tomomi, Walsh, Shannon M, Liu, Jianuo, Kipnis, Jonathan, Ikezu, Tsuneya · 2008 · The Journal of Immunology
33. A Fluorescent Pentameric Thiophene Derivative Detects in Vitro-Formed Prefibrillar Protein Aggregates
    Per Hammarström, Rozalyn A. Simon, Sofie Nyström, Peter Konradsson, Andreas Åslund, K. Peter R. Nilsson · 2010 · Biochemistry
34. Cellular Receptors of Amyloid β Oligomers (AβOs) in Alzheimer’s Disease
    Mroczko, Barbara, Groblewska, Magdalena, Litman-Zawadzka, Ala, Kornhuber, Johannes, Lewczuk, Piotr · 2018 · International Journal of Molecular Sciences
35. Quantitative Measurement of Changes in Amyloid-β(40) in the Rat Brain and Cerebrospinal Fluid following Treatment with the γ-Secretase Inhibitor LY-411575 [N2-[(2 S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7 S)-5-methyl-6-oxo-6,7-dihydro-5 H-dibenzo[b,d]azepin-7-yl]-l-alaninamide]
    Jonathan D. Best, Mark T. Jay, Franklin Otu, Jerome Ma, Alan J. Nadin, Semantha Ellis, Huw D. Lewis, Christine Pattison, Michael Reilly, Timothy Harrison et al. · 2005 · Journal of Pharmacology and Experimental Therapeutics
36. Why Alzheimer's is a disease of memory: The attack on synapses by Aß oligomers (ADDLs)
    Kirsten L. Viola, Pauline T. Velasco, W L Klein · 2008 · The journal of nutrition health & aging
37. Multifunctional roles of zinc in Alzheimer’s disease
    Zhuoya Xie, Hongrong Wu, Jianfeng Zhao · 2020 · NeuroToxicology
38. A Ganglioside-induced Toxic Soluble Aβ Assembly
    Naoki Yamamoto, Etsuro Matsubara, Sumihiro Maeda, Hirohisa Minagawa, Akihiko Takashima, Wakako Maruyama, Makoto Michikawa, Katsuhiko Yanagisawa · 2006 · Journal of Biological Chemistry
39. New Insights in Amyloid Beta Interactions with Human Telomerase
    Wang, Jiasi, Zhao, Chuanqi, Zhao, Andong, Li, Meng, Ren, Jinsong, Qu, Xiaogang · 2015 · Journal of the American Chemical Society
40. AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species
    Francesco Simone Ruggeri, Johnny Habchi, Andrea Cerreta, Giovanni Dietler · 2016 · Current Pharmaceutical Design
41. Blocking the Interaction between Apolipoprotein E and Aβ Reduces Intraneuronal Accumulation of Aβ and Inhibits Synaptic Degeneration
    Kuszczyk, Magdalena A., Sanchez, Sandrine, Pankiewicz, Joanna, Kim, Jungsu, Duszczyk, Malgorzata, Guridi, Maitea, Asuni, Ayodeji A., Sullivan, Patrick M., Holtzman, David M., Sadowski, Martin J. · 2013 · The American Journal of Pathology
42. Amyloid-β-induced Synapse Damage Is Mediated via Cross-linkage of Cellular Prion Proteins
    Clive Bate, Alun Williams · 2011 · Journal of Biological Chemistry
43. Neurotoxicity of General Anesthetics
    Misha A Perouansky, Hugh C. Hemmings, Bruno Riou · 2009 · Anesthesiology
44. A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid‐β oligomeric complexes
    Izumi Maezawa, Hyun‐Seok Hong, Hui‐Chuan Wu, Srinivas K. Battina, Sandeep Rana, Takeo Iwamoto, Gary A. Radke, Erik Pettersson, George M. Martin, Duy H. Hua et al. · 2006 · Journal of Neurochemistry
45. Structure – Function Relationships of Pre-Fibrillar Protein Assemblies in Alzheimers Disease and Related Disorders
    Farid Rahimi, Akila Shanmugam, Gal Bitan · 2008 · Current Alzheimer Research
46. A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease
    Lovell, Mark A. · 2009 · Journal of Alzheimer s Disease
47. Microarray Analysis Identifies Changes in Inflammatory Gene Expression in Response to Amyloid-β Stimulation of Cultured Human Retinal Pigment Epithelial Cells
    Khaliq H. Kurji, Jing Z Cui, Tony R. Lin, David I. Harriman, Shiv Shankar Prasad, Ljuba Kojic, Joanne Aiko Matsubara · 2010 · Investigative Ophthalmology & Visual Science
48. Reduced Alzheimer’s Disease Pathology by St. John’s Wort Treatment is Independent of Hyperforin and Facilitated by ABCC1 and Microglia Activation in Mice
    Jacqueline Hofrichter, Markus Krohn, Toni Schumacher, Cathleen Lange, Björn Feistel, Bernd Walbroel, Hans‐Jochen Heinze, Sara L. Crockett, Timothy F. Sharbel, Jens Pahnke · 2013 · Current Alzheimer Research
49. Amyloid-β Oligomers Induce Differential Gene Expression in Adult Human Brain Slices
    Adriano Silva Sebollela, Léo Freitas-Corrêa, Fabio Ferreira de Oliveira, Andrea Cristina Paula-Lima, Leonardo Martins Saraiva, Samantha M. Martins, Louise D. C. Mota, César Torres, Soniza Vieira Alves‐Leon, Jorge Marcondes de Souza et al. · 2012 · Journal of Biological Chemistry
50. Metal-dependent generation of reactive oxygen species from amyloid proteins implicated in neurodegenerative disease
    David Allsop, Jennifer Mayes, Susan Moore, Atef A. Masad, Brian J. Tabner · 2008 · Biochemical Society Transactions
51. Capping of Aβ42 Oligomers by Small Molecule Inhibitors
    Ziao Fu, Darryl Aucoin, Mahiuddin Ahmed, Martine Ziliox, William E. Van Nostrand, Steven O. Smith · 2014 · Biochemistry
52. Amyloid-like Conformation and Interaction for the Self-Assembly in Barnacle Underwater Cement
    Masahiro Nakano, Kei Kamino · 2014 · Biochemistry
53. Emerging signal regulating potential of small molecule biflavonoids to combat neuropathological insults of Alzheimer's disease
    Md. Sahab Uddin, Md. Tanvir Kabir, Devesh Tewari, Bijo Mathew, Lotfi Aleya · 2019 · The Science of The Total Environment
54. Functions of amyloid precursor protein in metabolic diseases
    Yanjun Guo, Qinqiu Wang, Shenghui Chen, Chengfu Xu · 2020 · Metabolism
55. Cotinine Reduces Amyloid-β Aggregation and Improves Memory in Alzheimer's Disease Mice
    Valentina Echeverrı́a, Ross Zeitlin, Sarah Burgess, Sagar P. Patel, Arghya Barman, Garima Thakur, Magorzota Mamcarz, Li Wang, David Barry Sattelle, Daniel A. Kirschner et al. · 2011 · Journal of Alzheimer s Disease
56. Alzheimer Aβ Peptide Induces Chromosome Mis-Segregation and Aneuploidy, Including Trisomy 21: Requirement for Tau and APP
    Antoneta Granic, Jaya Padmanabhan, Michelle Norden, Huntington Potter · 2009 · Molecular Biology of the Cell
57. Expression of nicotinic receptors on primary cultures of rat astrocytes and up-regulation of the α7, α4 and β2 subunits in response to nanomolar concentrations of the β-amyloid peptide1–42
    Jin Xiu, Agneta K. Nordberg, Juntian Zhang, Zhi-Zhong Guan · 2005 · Neurochemistry International
58. β-amyloid oligomers and cellular prion protein in Alzheimer’s disease
    Erik C. Gunther, Stephen M. Strittmatter · 2009 · Journal of Molecular Medicine
59. Systematic and standardized comparison of reported amyloid-β receptors for sufficiency, affinity, and Alzheimer's disease relevance
    Levi M. Smith, Mikhail A. Kostylev, Suho Lee, Stephen M. Strittmatter · 2019 · Journal of Biological Chemistry
60. Sampling the Self-Assembly Pathways of KFFE Hexamers
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61. Sporadic inclusion-body myositis: Conformational multifactorial ageing-related degenerative muscle disease associated with proteasomal and lysosomal inhibition, endoplasmic reticulum stress, and accumulation of amyloid-β42 oligomers and phosphorylated tau
    Valerie Askanas, W. King Engel · 2011 · La Presse Médicale
62. Insulin resistance, neuroinflammation, and Alzheimer’s disease
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63. β-Sheet Structured β-Amyloid(1-40) Perturbs Phosphatidylcholine Model Membranes
    Maurits R.R. de Planque, Vincent Raussens, Sonia Contera, Dirk T. S. Rijkers, Rob M. J. Liskamp, Jean‐Marie Ruysschaert, John Francis Ryan, Frances Separovic, Anthony Gordon Watts · 2007 · Journal of Molecular Biology
64. Methods for Analysis of Amyloid-β Aggregates
    Kim A. Bruggink, Mareike Müller, H. Bea Kuiperij, Marcel M. Verbeek · 2012 · Journal of Alzheimer s Disease
65. Does the Cytotoxic Effect of Transient Amyloid Oligomers from Common Equine Lysozyme in Vitro Imply Innate Amyloid Toxicity?
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66. Capillary electrophoresis studies on the aggregation process of β‐amyloid 1‐42 and 1‐40 peptides
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67. Thermodynamic Selection of Steric Zipper Patterns in the Amyloid Cross-β Spine
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68. Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates
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69. Hsp20, a novel α‐crystallin, prevents Aβ fibril formation and toxicity
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70. The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species
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71. An Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity?
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72. Modulation of Aβ 42 fìbrillogenesis by glycosaminoglycan structure
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73. Formation of Amyloids by Aβ-(1–42) on NGF-differentiated PC12 Cells: Roles of Gangliosides and Cholesterol
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74. Conformation-sensitive Antibodies against Alzheimer Amyloid-β by Immunization with a Thioredoxin-constrained B-cell Epitope Peptide
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75. Structure and Dynamics of Small Soluble Aβ(1–40) Oligomers Studied by Top-Down Hydrogen Exchange Mass Spectrometry
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76. Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin
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77. Conformer-Specific Hydrogen Exchange Analysis of Aβ(1–42) Oligomers by Top-Down Electron Capture Dissociation Mass Spectrometry
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78. Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1–42-Induced Rat Model of Alzheimer’s Disease
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79. Solid-state NMR as a method to reveal structure and membrane-interaction of amyloidogenic proteins and peptides
    Akira Naito, Izuru Kawamura · 2007 · Biochimica et Biophysica Acta (BBA) - Biomembranes
80. Inhibition of Alzheimer’s amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo
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81. The amyloid precursor protein (APP) processing as a biological link between Alzheimer’s disease and cancer
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82. Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012)
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83. Influence of Multiple Metal Ions on β-Amyloid Aggregation and Dissociation on a Solid Surface
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84. Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease
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85. APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease
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86. Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives
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87. Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin
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88. Targets for AD treatment: conflicting messages from γ-secretase inhibitors
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89. Aggregation and fibril morphology of the Arctic mutation of Alzheimer’s Aβ peptide by CD, TEM, STEM and in situ AFM
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90. The Polyphenol Piceid Destabilizes Preformed Amyloid Fibrils and Oligomers In Vitro: Hypothesis on Possible Molecular Mechanisms
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91. Small Molecule Inhibitors of Lysozyme Amyloid Aggregation
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93. Actin dynamics shape microglia effector functions.
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94. Human Prefoldin Inhibits Amyloid-β (Aβ) Fibrillation and Contributes to Formation of Nontoxic Aβ Aggregates
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95. Amyloid β peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway
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96. Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Aβ oligomer-induced cytotoxicity
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97. G Protein–Coupled Receptors, Cholinergic Dysfunction, and Aβ Toxicity in Alzheimer’s Disease
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98. Amyloid-β42 is preferentially accumulated in muscle fibers of patients with sporadic inclusion-body myositis
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99. Fluorinated beta-sheet breaker peptides
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100. Glial and endothelial blood-retinal barrier responses to amyloid-β in the neural retina of the rat
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