Protein Kinase CK1δ Phosphorylates Key Sites in the Acidic Domain of Murine Double-Minute Clone 2 Protein (MDM2) That Regulate p53 Turnover

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Damage-mediated Phosphorylation of Human p53 Threonine 18 through a Cascade Mediated by a Casein 1-like Kinase

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Hypophosphorylation of Mdm2 Augments p53 Stability

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Critical Role for a Central Part of Mdm2 in the Ubiquitylation of p53

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Regulation of p53 - insights into a complex process

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MDM2’s social network

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DNAJB1 stabilizes MDM2 and contributes to cancer cell proliferation in a p53-dependent manner

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Autoactivation of the MDM2 E3 Ligase by Intramolecular Interaction

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Casein Kinase 1δ Inhibitors as Promising Therapeutic Agents for Neurodegenerative Disorders

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MDM2 oligomers: antagonizers of the guardian of the genome

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Circadian gene CSNK1D promoted the progression of hepatocellular carcinoma by activating Wnt/β-catenin pathway via stabilizing Dishevelled Segment Polarity Protein 3

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Casein kinase 1α has a non-redundant and dominant role within the CK1 family in melanoma progression

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Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 through recruitment of protein kinase CK2

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A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway

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Casein kinase 1δ activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity

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Activation of p53: How phosphorylated Ser15 triggers sequential phosphorylation of p53 at Thr18 by CK1δ

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The p53-Mdm2 Loop: A Critical Juncture of Stress Response

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Set the Tone:

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The DNA Damage Repair Function of Fission Yeast CK1 Involves Targeting Arp8, a Subunit of the INO80 Chromatin Remodeling Complex

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Fission yeast CK1 promotes DNA double-strand break repair through both homologous recombination and non-homologous end joiningPreprint

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The Role of Protein Kinase CK2 in the p53 Response

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Kinases and Cancer

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Xenobiotics-induced phosphorylations of MDM2

Pääjärvi, G. (2006) · Figshare

Novel concepts in MDM2 protein regulation

Worrall, E. G. (2009) · ERA

The disordered region 1 of Mdm2 weakens p53-binding in both its unmodified and hyperphospho-formsPreprint

Theillet, F., Luo, Y., Bouguechtouli, C., Procaccia, J., Alik, A., & Nicaise, M. (2026) · Research Square · doi:10.21203/rs.3.rs-9014206/v1

A metabolic crosstalk between liposarcoma and skeletal muscle sustains tumor growth

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Impact of protein-protein interactions and phosphorylation on RNA decapping for nonsense mediated mRNA decay (NMD)

Gilbert, A. (2022) · doi:10.70675/23033c79z3c96z49d0zb6a4zd616da715c43

Cell cycle-coupled CK1δ turnover, autoinhibition, and activityPreprint

Serrano, F. E., Ruppert, B., Diernfellner, A. C. R., & Brunner, M. (2026) · eLife · doi:10.7554/elife.112381.2

BindingDB Entry 50043431: A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway.

BindingDB (2014) · UC San Diego · doi:10.7270/q2q52r2m

Phosphorylation of the acidic domain of Mdm2 by protein kinase CK2

Allende-Vega, N., Dias, S. S., Milne, D., & Meek, D. W. (2005) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-3074-4 · Cited by 35 · see citing works

Phosphorylation of murine double minute clone 2 (MDM2) protein at serine-267 by protein kinase CK2 in vitro and in cultured cells

Hjerrild, M., Milne, D., Dumaz, N., Hay, T., Issinger, O., & Meek, D. W. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3550347 · Cited by 45 · see citing works

Polo‐like kinase‐1 phosphorylates MDM2 at Ser260 and stimulates MDM2‐mediated p53 turnover

Dias, S. S., Hogan, C., Ochocka, A. M., & Meek, D. W. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.09.057 · Cited by 39 · see citing works

Casein Kinase 1 alpha - MDM2 complex: phosphorylation and ubiquitination signals converging on p53 pathway

Huart, A.-S. (2014) · Edinburgh Research Archive (University of Edinburgh)

Identification of a CK2 phosphorylation site in mdm2.

Götz, C., Kartarius, S., Scholtes, P., Nastainczyk, W., & Montenarh, M. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00882.x · Cited by 39 · see citing works