Comparative Analysis of Calcineurin Inhibition by Complexes of Immunosuppressive Drugs with Human FK506 Binding Proteins

Weiwad, Matthias; Edlich, Frank; Kilka, Susann; Erdmann, Frank; Jarczowski, Franziska; Dorn, Madlen; Moutty, Marie-Christine; Fischer, Gunter

doi:10.1021/bi061616p

Comparative Analysis of Calcineurin Inhibition by Complexes of Immunosuppressive Drugs with Human FK506 Binding Proteins

Multiple intracellular receptors of the FK506 binding protein (FKBP) family of peptidylprolyl cis/trans-isomerases are potential targets for the immunosuppressive drug FK506. Inhibition of the protein phosphatase calcineurin (CaN), which has been implicated in the FK506-mediated blockade of T cel…