The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4

Bae, Chilman, Sachs, Frederick, Gottlieb, Philip A.·2011·Biochemistry

Cited by (568)

Items 501–568 of 568

  1. Lipid Peroxidation Accompanied by Increased Ion Permeability of the Plasma Membrane Engender Ferroptosis
    Yusuke Hirama, Atsushi Matsuzawa, Spencer A. Freeman, Sergio Grinstein · 2022 · SSRN Electronic Journal
  2. Mechanical force sensing drives extrusion of Enterovirus A71-infected cells from colonic epithelial organoids
    Jasmine Moshiri, Ailsa R. Craven, Sara Mixon, Manuel Ricardo Amieva, Karla Kirkegaard · 2022 · Research Square
  3. The protein-bound uremic solute 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) increases erythrocyte osmotic fragility through interaction with the mechanosensitive channel Piezo1
    Beatriz Akemi Kondo Van Spitzenbergen, Gabriela Bohnen, Erika Sousa Dias, Júlia Bacarin Monte Alegre, Gabriela Ferreira Dias, Nadja Grobe, Andréa Novais Moreno-Amaral, Peter Kotanko · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  4. Harnessing Mechanical Forces for Cancer Treatment
    Alka Kumari, SR Veena, Rashmita Luha, Ajay Tijore · 2023 · Preprints.org
  5. Involvement of Piezo 1 channels in vascular stiffness in isolated small resistance arteries of male and female Dahl salt-sensitive hypertensive rats
    Eric Mensah, Noriko Daneshtalab, Reza Tabrizchi · 2023
  6. An EPHB4-RASA1 signaling complex inhibits shear stress-induced Ras-MAPK activation in lymphatic endothelial cells to promote the development of lymphatic vessel valves
    Di Chen, David Wiggins, Eva Marie Sevick-Muraca, Michael J. Davis, Philip D. King · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  7. Deciphering glycoprotein VI signalling in platelet activation
    Hilaire Yam Fung Cheung · 2023
  8. Transient and persistent aspects of human platelet activation
    Jinmi Zou · 2024
  9. Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi
    2024 · European Light Microscopy Initiative Meeting (ELMI)
  10. PIEZO-dependent mechano-sensing of the niche is essential for intestinal stem cell fate decision and maintenance
    Meryem B. Baghdadi, Ronja M. Houtekamer, Louisiane Perrin, Abilasha Rao‐Bhatia, Myles Whelen, Linda Decker, Martin Bergert, Carlos Perez Gonzalez, Réda Bouras, Giacomo Gropplero et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  11. Molluscan and Arthropod Neurotoxins
    Rocio K. Finol‐Urdaneta · 2025 · Elsevier eBooks
  12. EGFR-Mediated Mechanotransduction in Aortic Valve Cells: A Key Pathway in Response to Wall Shear Stress
    Amélie Gasté, Damien Marchese, Adèle Faucherre, Louna Lopez, Éric Bertrand, Alexis Théron, Marine Herbane, Amel Seddik, Chris Jopling, Jean-François Aviérinos et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Elevated hydrostatic pressure acts via piezo-1 to destabilise VE-cadherin junctions: an endothelium-on-chip study
    Pranav Vasanthi Bathrinarayanan, Thomas Abadie, Patricia Pérez Esteban, Daniele Vigolo, Mark J.H. Simmons, Liam Michael Grover · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  14. Cerebellum-Targeted Transcranial Focused Ultrasound Stimulation Modulates Hippocampus Neural Activities
    Yingjian Liu, King Yi Cho, Jacky Tin Shing Hung, Caiyi Zhuo, H. M. Lai, Chung Tin · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Propofol inhibits Piezo mechanosensitive channels
    Donggyeom Yu, Chilman Bae · 2025 · Biophysical Journal
  16. Remote magnetomechanical neuromodulation uncovers a novel therapeutic mechanism for alleviating Parkinsonian symptoms in freely moving mice
    Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Sophia Gimple, Renzo J. M. Riemens, Günter Kenis, Kim Rijkers, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  17. Robust pan-junctional reinforcement preserves the gut epithelial barrier under mechanical stress
    Vishnu Krishnakumar, Angela Ferran, Sandra Bernat-Fabre, Justine Creff, Silvia Kocanova, Nicolas Cénac, Denis Krndija · 2026 · Science Advances
  18. Airway epithelia clear rhinovirus infection via two waves of cell extrusion
    Faith Fore, Dustin Bagley, Rocío T. Martínez-Nuñez, Julia Aniscenko, Sebastian Lennox Johnston, Jody Rosenblatt · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  19. Upregulation of Intracellular Calcium by Piezo1 Activation Mediates UTMD-Activated ATP Release by Rat Erythrocytes
    Anna Xu, Qiong N. Zhu, Yanshuo Shi, Lei Gao, Zheng Liu, Yueheng Wang · 2025 · Ultrasound in Medicine & Biology
  20. Additional file 1 of Microglial amyloid beta clearance is driven by PIEZO1 channels
    Henna Jäntti, Valeriia Sitnikova, Yevheniia Ishchenko, Anastasia Shakirzyanova, Luca Giudice, Ugidos, Irene F., Mireia Gómez‐Budia, Nea Korvenlaita, Sohvi Ohtonen, Irina Belaya et al. · 2022 · Figshare
  21. Fluorescent peptides for membrane tension and domain structure reporting
    Thomas M. Suchyna, Jake Rosetto, Hannah Cetuk, Andriy Anishkin, Sergei Sukharev · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Sensibilité des cellules de Merkel humaines au froid : vers un rôle des complexes de Merkel dans la sensibilité thermique cutanée ?
    Yann Roudaut · 2014 · theses.fr (ABES)
  23. Physiopathologie et génétique de la bicuspidie aortique non syndromique
    Alexis Théron · 2017
  24. Rôle des forces hémodynamiques sur l’expression de composants de la matrice extracellulaire au cours du développement normal et pathologique de la valve aortique
    Pierre Rambeau · 2019
  25. Rôle de PIEZO1 au cours de la différentiation érythroïde normale et des stomatocytoses à cellules déshydratées
    Alexis Caulier · 2020 · theses.fr (ABES)
  26. Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice
    Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Sophia Gimple, Renzo J. M. Riemens, Günter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel et al. · 2026 · Advanced Science
  27. Characterization of cationic conductances of human erythrocytes and their involvement in health and disease
    David Monedero Alonso · 2019
  28. Étude des bases moléculaires de la mécanotransduction du système somatosensoriel
    Lucie Brosse · 2021
  29. Dynamique des globules rouges dans les fentes spléniques biomimétiques
    Alexis Moreau · 2021
  30. Rôle de la stomatine dans la modulation de canaux ioniques mécanosensibles : impact sur les défauts d'hydratation du globule rouge
    Sarah L. S. Rougé · 2022
  31. Characterization of cationic conductance in Red Blood Cells; insights from pharmacological and pathophysiological studies
    Aline Hatem · 2024
  32. Cerebellar focused ultrasound stimulation modulates neural response at hippocampus and suppresses epileptiform activity
    Yingjian Liu, King Yi Cho, Jacky Tin Shing Hung, Caiyi Zhuo, Wenxin Shi, Hei Ming Lai, Chung Tin · 2026 · Brain stimulation
  33. Otenabant is a Selective Antagonist of Human PIEZO1
    Vincent Jaquet, Reeta Penttinen, Gorane Rodríguez-Urquirizar, Cyril Castelbou, Yves Cambet, Nicolas Rosa, Mathilde Bourdin, Bita Asghariastanehei, Franciele de Lima, Marie Martin et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  34. Unresolved mechanisms: a hypothesized spatial regulation of myosin light chain phosphorylation within the walls of resistance arteries
    Zhe Sun, M. R. Hill · 2026 · Frontiers in Physiology
  35. Yoda molecules agonize PIEZO2
    Tharaka Darshana Wijerathne, Aneesh Chandrasekharan, Aashish Bhatt, Yun Luo, Jérôme J. Lacroix · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  36. Flow-Induced Yap/Taz Signaling Balances Endothelial and Hematopoietic Stem Cell Fates
    Wade W. Sugden, Stephan George, Zachary C. LeBlanc, Morgan T. Walcheck, Eleanor Meader, Julia Goldstein, Elizabeth Molnar, Wandi Zhu, Rubul Mout, Christopher Li et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  37. Peripheral targets for neuropathic pain
    Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer · 2026 · British Journal of Pharmacology
  38. Modulating the Tumor Microenvironment: Small-Molecule Strategies in Combination Regimens
    Samrat Daripa, Sumit Kumar Hira · 2026 · Springer eBooks
  39. Hypertonicity and Piezo1 Activation Enhance Radiosensitivity of B16 Melanoma
    Yusei Yagi, Kazuki Kitabatake, Mitsutoshi Tsukimoto · 2026 · Biological and Pharmaceutical Bulletin
  40. Yoda molecules agonize PIEZO2
    Tharaka Darshana Wijerathne, Aneesh Chandrasekharan, Aashish Bhatt, Yun Luo, Jérôme J. Lacroix · 2026 · eLife
  41. Piezo2 + mechanosensory neurons and glial cells initiate resident macrophage activation in postoperative ileus
    Zheng Wang, Elodie Modave, Samuel Van Remoortel, Nika Pajk, Pieter Vanden Berghe, Yifan Chen, Marte Vandeput, Iris Appeltans, Runze Quan, Gianluca Matteoli et al. · 2026 · Gut
  42. Functional Role of Piezo1 in Regulating Whole‐Lung Vascular Reactivity
    Sophia Parmisano, Jiyuan Chen, Yuqin Chen, Pritesh Jain, Lauren Yung, Wei‐Ting Wang, Ting Wang, X Li, Angela Balistrieri, Sophia A. Ferrizzi et al. · 2026 · Pulmonary Circulation
  43. Piezo1 Mechanotransduction in Skeletal Muscle: Convergence with Noncoding RNA Regulation in Myogenesis, Regeneration, and Sarcopenia
    Thanh Huu Phan Ngo, Jiwon Oh, Hyeong Jun Kim, Wan Lee · 2026 · International Journal of Molecular Sciences
  44. A Reduced Mechanobiological Framework for Platelet Priming: From Hemodynamic Shear to Mechanosensitive Calcium Entry
    Yuxin Chen, Xiaochen Liu, Daniele Vigolo, Siyuan Zhuang, Ken‐Tye Yong · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  45. Piezo1 and Piezo2 in neurological disorders: From mechanotransduction to therapeutic potential
    Lu Zhao, Chao Wang, Yudan Zhu, Qian Xiao, Jie Tao · 2026 · Current Opinion in Pharmacology
  46. Calcium hydroxyapatite suppresses extracellular matrix-related gene expression by modulating Piezo1-associated Ca 2+ signaling and PKA activity
    ChanHui Song, Younjee Jeong, Tae‐Jin Kim · 2026 · Animal Cells and Systems
  47. Swelling-induced calcium signaling in wild-type and Mlc1-null astrocytes: paradoxical effects of pharmacological TRPV4 and Piezo1 inhibition
    Quinty Bisseling, Vera Kuhnke, Maria Stefania Brignone, Elena Ambrosini, Huibert D. Mansvelder, Marjo S. van der Knaap, Rogier Min · 2026 · Frontiers in Cellular Neuroscience
  48. Soft tissue mechanosensing and remodeling: the core regulatory role of Piezo/TRPV4 ion channels
    Xuanqiang Fan, Mingwei Shi, Zhen Wang, Chi Zhao, Yifan Zhao, Yunfeng Zhou, Hui Xu · 2026 · Frontiers in Cell and Developmental Biology
  49. Piezo1 channel: structure, mechanogating mechanism, functions, diseases and therapeutic strategy
    Qixiang Wu, Ying Hu, Yuhan Wang, Fuqiang Zhu, Qiongyu Xu, Ling Xu, Jinguo Xu, Tao Xu · 2026 · Molecular Biomedicine
  50. Mammalian TMC Family Proteins are Mechanically Gated Ion Channels
    Songdi Fu, Jianying Dong, Xing Luo, Ting Xie, Wei Li, Yufei Luo, Zhiqiang Yan · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  51. Piezo1 balances focal and reticular adhesions to enable EGFR clathrin-mediated endocytosis
    Oriol Bagudanch, Ona Zoroa, Valentina Ayala, Roy Midyan, Dustin Bagley, Satish Babu Moparthi, Zaber Shabib, Laura Hakanpää, An-Sofie Lenaerts, Le­onardo Almeida-Souza et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  52. Hardened ground: ECM stiffness as a unifying biomechanical driver of reproductive stem cell aging
    Onder Celik, Nur Dokuzeylul Gungor, Aynur Erşahin, Nilufer Celik, Aziz İhsan Tavuz, Yasemin Kızılkaya, Sudenaz Celik, Kağan Güngör · 2026 · Biogerontology
  53. A bioactive polyurethane adhesive delivers interfacial mechano-biochemical cues for meniscus tear repair
    Xiaolong Yang, Lin Yang, Shiji Gao, Yi Zhou, Zhe Xu, Junqiao Li, Jiehua Li, Hong Tan, Feng Luo, Weili Fu · 2026 · Acta Biomaterialia
  54. Intracellular mechanosensation in intestinal smooth muscle: Piezo1 complexes amplify signalling beyond the surface
    Geoanna M. Bautista, Declan Manning, Emily C. Lieu, Stephanie I. Ugochukwu, Collin Matsumoto, Joshua P. Tulman, Miguel A. S. Martín‐Aragón Baudel, Nuria Daghbouche-Rubio, Steven J. McElroy, Salah A. Baker et al. · 2026 · The Journal of Physiology
  55. Biomechanical regulation of bladder injury and repair
    Jiawei Chen, Yuanzhuo Chen, Xingpeng Di, Xiao Zeng, Sihong Shen, Lede Lin, Ya Li, Banghua Liao, Hong Shen, Liao Peng et al. · 2026 · Nature Reviews Urology
  56. Pathological Mechanisms of Tendinopathy Pain: From Mechanical Overload to Neuroimmune–Vascular Crosstalk
    Chenyu He, Aikang Li, Qingyi Liu, Mingyang Xu, Hongbo You, Hewei Li · 2026 · Pain Research and Management
  57. Piezo1 in Peripheral and Central Sensitisation: Implications for Chronic Pain
    Olga Kopach · 2026 · Bioengineering
  58. Fluid Shear Stress Drives Endothelial Glycolytic Reprogramming via an AIBP/VEGF Axis
    Linhua Zhou, Xiaowu He, Yaowu Liu, Yanpeng Wei, Yiting Yang, Qi Zhang · 2026 · Biology
  59. Airway epithelia clear rhinovirus infection via two waves of cell extrusion
    Faith Fore, Dustin Bagley, Rocío T. Martínez-Nuñez, Julia Aniscenko, Sebastian Lennox Johnston, Jody Rosenblatt · 2026 · Science Advances
  60. Research Progress on the Mechanism of Piezol-Mediated Autophagy and Tuina in Knee Osteoarthritis
    Hui Xu, Fang Liu, Shuang Liang, YunMa, Xuanqiang Fan, Yifan Zhao, Danyang Li, Mingwei Shi, Mengmeng Li, Yunfeng Zhou · 2026 · Chinese medicine and natural products
  61. Mechanoinflammation: mechanosensing and inflammatory amplification through the airway macrophage Piezo1–NLRP3 axis in cough-variant asthma
    Suping Yu, Xianqing Ren, Ying Ding, Yan Xu, Mengmeng Sun, Guichun Zhang, Bingxue Zhang, Qiongqiong Xing, Guihua SONG, Haitao Wang · 2026 · Frontiers in Immunology
  62. Ligand-specific endothelial Notch signaling coordinates brain pericyte specification and expansion
    Huaxing Zi, Chi Dang, Weiyi Sima, Xiaoyu Li, Guozhu Ning, Li Sun, Qiang Wang, Jingjing Zhang · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  63. Post-translational activation of Mmp2 by Mmp14b is triggered by mechanical signalling through Piezo1 and ERK during embryonic growth in the zebrafish
    Jillian Hickey, Brennen Peters, Bryan D. Crawford · 2026 · SSRN Electronic Journal
  64. Research Progress on the Mechanosensitive Ion Channel Piezo1 in Glaucoma
    Ningmeng Hu · 2026 · Advances in Clinical Medicine
  65. Mechanochemical coupling in lung cancer: how tissue tension drives genomic instability and malignant progression
    Tianli Wang, Qiang Xiao · 2026 · Frontiers in Cell and Developmental Biology
  66. BindingDB Entry 50017231: Piezo-Type Mechanosensitive Ion Channel Component 1 (Piezo1): A Promising Therapeutic Target and Its Modulators.
    BindingDB · 2023 · UC San Diego
  67. BindingDB Entry 50022022: Piezo1 and its inhibitors: Overview and perspectives.
    BindingDB · 2025 · UC San Diego
  68. Piezo1 mechanobiology in high myopia and glaucoma: compartment-specific evidence, gaps, and a hypothesis-generating susceptibility framework
    Cong Zhao, Gong Chen, Chun Wang, Huihui Chen, Jingming Shi · 2026 · Frontiers in Bioengineering and Biotechnology