The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4

Bae, Chilman, Sachs, Frederick, Gottlieb, Philip A.·2011·Biochemistry

Cited by (568)

Items 201–300 of 568

  1. Mechanosensitive Ca 2+ permeant cation channels in human prostate tumor cells
    Rosario Maroto, Alexander Kurosky, Owen P. Hamill · 2012 · Channels
  2. Piezo1 Channel as a Potential Target for Hindering Cardiac Fibrotic Remodeling
    Nicoletta Braidotti, Suet Nee Chen, Carlin S. Long, Dan Cojoc, Orfeo Sbaizero · 2022 · International Journal of Molecular Sciences
  3. The mechano-gated channel inhibitor GsMTx4 reduces the exercise pressor reflex in rats with ligated femoral arteries
    Steven W. Copp, Joyce S. Kim, Víctor Ruiz-Velasco, Marc P. Kaufman · 2016 · American Journal of Physiology-Heart and Circulatory Physiology
  4. The oscillation of intracellular Ca2+ influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium
    Tatsuya Ihara, Takahiko Mitsui, Yuki Nakamura, Mie Kanda, Sachiko Tsuchiya, Satoru Kira, Hiroshi Nakagomi, Norifumi Sawada, Manabu Kamiyama, Yuri Hirayama et al. · 2018 · Scientific Reports
  5. The mechanosensitive channel Piezo1 cooperates with semaphorins to control neural crest migration
    Brenda Canales Coutiño, Roberto Mayor · 2021 · Development
  6. Mechanistic insights into ultrasonic neurostimulation of disconnected neurons using single short pulses
    Eyal Weinreb, Elisha Moses · 2022 · Brain stimulation
  7. Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis
    Shafiu A. Umar Shinge, Daifang Zhang, Tobias Achu Muluh, Yongmei Nie, Fengxu Yu · 2021 · Journal of Inflammation Research
  8. Roles of the mechanosensitive ion channel Piezo1 in the renal podocyte injury of experimental hypertensive nephropathy
    Satoyuki Ogino, Kei Yoshikawa, Takashi Nagase, Kaori Mikami, Miki Nagase · 2023 · Hypertension Research
  9. The role of mechanically sensitive ion channel Piezo1 in bone remodeling
    Yugui Du, Bowen Xu, Quiying Li, Chuhan Peng, Kai Yang · 2024 · Frontiers in Bioengineering and Biotechnology
  10. The Role of Toxins in the Pursuit for Novel Analgesics
    Yossi Maatuf, Matan Geron, Avi Priel · 2019 · Toxins
  11. Amphipathic molecules modulate PIEZO1 activity
    Charles David Cox, Philip A. Gottlieb · 2019 · Biochemical Society Transactions
  12. Inhibition of Shear-Induced Platelet Aggregation by Xueshuantong via Targeting Piezo1 Channel-Mediated Ca2+ Signaling Pathway
    Lei Liu, Qiong-Ling Zhang, Shunli Xiao, Zhengxiao Sun, Shilan Ding, Ying Chen, Lan Wang, Xiaojie Yin, Fulong Liao, Lin‐Hua Jiang et al. · 2021 · Frontiers in Pharmacology
  13. The mechanosensitive Piezo1 channel controls endosome trafficking for an efficient cytokinetic abscission
    Julia Carrillo-García, Víctor Herrera-Fernández, Selma Angèlica Serra, Fanny Rubio-Moscardó, Marina Vogel-González, Pau Doñate‐Macian, Covadonga F. Hevia, Cristina Pujades, Miguel Angel Valverde · 2021 · Science Advances
  14. Cellular crowding influences extrusion and proliferation to facilitate epithelial tissue repair
    Jovany J. Franco, Youmna Atieh, Chase D. Bryan, Kristen M. Kwan, George T. Eisenhoffer · 2019 · Molecular Biology of the Cell
  15. The biophysics of piezo1 and piezo2 mechanosensitive channels
    Luca Soattin, Michele Fiore, Paola Gavazzo, Federica Viti, Paolo Facci, Roberto Raiteri, Francesco Difato, Michael Pusch, Massimo Vassalli · 2015 · Biophysical Chemistry
  16. PIEZO1-mediated mechanosensing governs NK-cell killing efficiency and infiltration in three-dimensional matrices
    Yanamandra, Archana K., Zhang, Jingnan, Montalvo, Galia, Zhou, Xiangda, Biedenweg, Doreen, Zhao, Renping, Sharma, Shulagna, Hoth, Markus, Lautenschläger, Franziska, Otto, Oliver et al. · 2024 · European Journal of Immunology
  17. Identification and functional characterization of the Piezo1 channel pore domain
    E. D. Nosyreva, David Thompson, Ruhma Syeda · 2020 · Journal of Biological Chemistry
  18. Jatrorrhizine inhibits Piezo1 activation and reduces vascular inflammation in endothelial cells
    Tianying Hong, Xianmei Pan, Xu Han, Zhijuan Zheng, Lizhen Wen, Jing Li, Mingfeng Xia · 2023 · Biomedicine & Pharmacotherapy
  19. Calcium Signaling in Live Cells on Elastic Gels under Mechanical Vibration at Subcellular Levels
    Wagner Shin Nishitani, Taher A. Saif, Yingxiao Wang · 2011 · PLoS ONE
  20. The potential role of mechanosensitive ion channels in substrate stiffness-regulated Ca2+response in chondrocytes
    Genlai Du, Weiyi Chen, Li Li, Quanyou Zhang · 2021 · Connective Tissue Research
  21. The functional effects of Piezo channels in mesenchymal stem cells
    Zhilong Huang, Yingying Huang, Xiner Ning, Haodi Li, Qiqi Li, Junjie Wu · 2023 · Stem Cell Research & Therapy
  22. Inhibition of Piezo1 Ameliorates Intestinal Inflammation and Limits the Activation of Group 3 Innate Lymphoid Cells in Experimental Colitis
    Chang Liu, Yanan Xia, Shi-Chen Fu, Fanyi Meng, Bingcheng Feng, Leiqi Xu, Lixiang Li, Xiuli Zuo · 2023 · Journal of Innate Immunity
  23. Newly identified roles for PIEZO1 mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis
    Vittorio Abbonante, Anastasia Iris Karkempetzaki, Catherine Léon, Anandi Krishnan, Nasi Huang, Christian Andrea Di Buduo, Daniele Cattaneo, Christina Marie Ward, Shinobu Matsuura, Inès Guinard et al. · 2024 · American Journal of Hematology
  24. Ion channel mediated mechanotransduction in immune cells
    Hamza Atcha, Amit Jairaman, Elizabeth L. Evans, Medha M. Pathak, Michael D. Cahalan, Wendy F. Liu · 2021 · Current Opinion in Solid State and Materials Science
  25. PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis
    Shirin Pourteymour, Jingxue Fan, Rakesh Kumar Majhi, Shuyuan Guo, Xin Sun, Zhen Huang, Ying Liu, Hanna Winter, Alexandra Bäcklund, Nikolaos-Taxiarchis Skenteris et al. · 2024 · Cellular and Molecular Life Sciences
  26. Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity?
    Gemma Mazzuoli‐Weber, Eva Maria Kugler, Carina Ines Bühler, Florian Kreutz, İhsan Ekin Demir, Onur Güralp Ceyhan, Florian Zeller, Michael Schemann · 2018 · Cell and Tissue Research
  27. Study on the mechanism of excessive apoptosis of nucleus pulposus cells induced by shRNA‐Piezo1 under abnormal mechanical stretch stress
    Qining Yang, Yongwei Zhou, Jinhua Wang, Weicong Fu, Xiaofei Li · 2018 · Journal of Cellular Biochemistry
  28. NLRP3-Mediated Piezo1 Upregulation in ACC Inhibitory Parvalbumin-Expressing Interneurons Is Involved in Pain Processing after Peripheral Nerve Injury
    Qiaoyun Li, Yi-Wen Duan, Yao-Hui Zhou, Shaoxia Chen, Yong-Yong Li, Ying Zang · 2022 · International Journal of Molecular Sciences
  29. Piezo1 in PASMCs: Critical for Hypoxia-Induced Pulmonary Hypertension Development
    Fenja Knoepp, Shariq Abid, Amal Houssaini, Larissa Lipskaia, Mira Y. Gökyildirim, Emmanuelle Born, Élisabeth Marcos, Malika Arhatte, Edyta Glogowska, Nora Vienney et al. · 2025 · Circulation Research
  30. Mechanical and chemical activation of GPR68 probed with a genetically encoded fluorescent reporter
    Alper Devrim Özkan, Tina Gettas, Audrey Sogata, Wynn Phaychanpheng, Miou Zhou, Jérôme J. Lacroix · 2021 · Journal of Cell Science
  31. Weak Ultrasound Contributes to Neuromodulatory Effects in the Rat Motor Cortex
    Po-Chun Chu, Chen‐Syuan Huang, Pi-Kai Chang, Rou‐Shayn Chen, Ko‐Ting Chen, Tsung-Hsun Hsieh, Hao‐Li Liu · 2023 · International Journal of Molecular Sciences
  32. Macrophages induce gingival destruction via Piezo1-mediated MMPs-degrading collagens in periodontitis
    Tong Zhao, Zhuangzhuang Chu, Catherine Huihan Chu, Shuo Dong, Guoqing Li, Jin Chuan Wu, Chunbo Tang · 2023 · Frontiers in Immunology
  33. Mechanosensitive Cation Channel Piezo1 Is Involved in Renal Fibrosis Induction
    Marta Drobnik, Jakub Smólski, Łukasz Grądalski, Szymon Niemirka, Ewelina Młynarska, Jacek Rysz, Beata Franczyk · 2024 · International Journal of Molecular Sciences
  34. PIEZO1 is a distal nephron mechanosensor and is required for flow-induced K+ secretion
    Rolando Carrisoza‐Gaytan, Stephanie M. Mutchler, Francisco Carattino, Joanne Soong, Marianela G. Dalghi, Peng Wu, Wen‐Hui Wang, Gerard L. Apodaca, Lisa M. Satlin, Thomas R. Kleyman · 2024 · Journal of Clinical Investigation
  35. Pain-related toxins in scorpion and spider venoms: a face to face with ion channels
    Sylvie Diochot · 2021 · The Journal of venomous animals and toxins including tropical diseases
  36. Piezo1 regulates shear-dependent nitric oxide production in human erythrocytes
    Lennart Kuck, Jason N. Peart, Michael J. Simmonds · 2022 · American Journal of Physiology-Heart and Circulatory Physiology
  37. RBCs prevent rapid PIEZO1 inactivation and expose slow deactivation as a mechanism of dehydrated hereditary stomatocytosis
    Elizabeth L. Evans, Oleksandr V. Povstyan, Dario De Vecchis, Fraser L. Macrae, Laeticia Lichtenstein, Timothy Simon Futers, Gregory Parsonage, Neil E. Humphreys, Antony D. Adamson, Antreas C. Kalli et al. · 2020 · Blood
  38. The Molecular Basis for Altered Cation Permeability in Hereditary Stomatocytic Human Red Blood Cells
    Joanna F. Flatt, Lesley J. Bruce · 2018 · Frontiers in Physiology
  39. Mechanosensitive extrusion of Enterovirus A71-infected cells from colonic organoids
    Jasmine Moshiri, Ailsa R. Craven, Sara Mixon, Manuel Ricardo Amieva, Karla Kirkegaard · 2023 · Nature Microbiology
  40. GsMTx4-D provides protection to the D2.mdx mouse
    Christopher W. Ward, Frederick Sachs, Ernest D. Bush, Thomas M. Suchyna · 2018 · Neuromuscular Disorders
  41. Mechanosensitivity is an essential component of phototransduction in vertebrate rods
    Ulisse Bocchero, Fabio Falleroni, Simone Mortal, Yunzhen Li, Dan Cojoc, Trevor D. Lamb, Vincent Torre · 2020 · PLoS Biology
  42. Up-down biphasic volume response of human red blood cells to PIEZO1 activation during capillary transits
    Simon Rogers, Virgilio L. Lew · 2021 · PLoS Computational Biology
  43. The mechanopathology of the tumor microenvironment: detection techniques, molecular mechanisms and therapeutic opportunities
    Stella Angeli, Constantina Neophytou, Maria Kalli, Triantafyllos Stylianopoulos, Fotios Mpekris · 2025 · Frontiers in Cell and Developmental Biology
  44. Exaggerated mechanoreflex in early-stage type 1 diabetic rats: role of Piezo channels
    Ann‐Katrin Grotle, Elizabeth A. Garcia, Michelle Harrison, Yu Huo, Charles K. Crawford, Kai M. Ybarbo, Audrey J. Stone · 2019 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  45. Mechanosensitivity in Pulmonary Circulation: Pathophysiological Relevance of Stretch-Activated Channels in Pulmonary Hypertension
    Solène Barbeau, Guillaume Gilbert, Guillaume Cardouat, Isabelle Baudrimont, Véronique Freund‐Michel, Christelle Guibert, Roger Marthan, Pierre Vacher, Jean‐François Quignard, Thomas Ducret · 2021 · Biomolecules
  46. Mechanosensitive Ion Channels, Axonal Growth, and Regeneration
    Leann Miles, Jackson Ross Powell, Casey Kozak, Yuanquan Song · 2022 · The Neuroscientist
  47. Probing mammalian touch transduction
    Diana M. Bautista, Ellen A. Lumpkin · 2011 · The Journal of General Physiology
  48. Piezo1:the potential new therapeutic target for fibrotic diseases
    Xin Zhe Liu, Weipin Niu, Shuqing Zhao, Wenjuan Zhang, Zhao Ying, Jing Li · 2023 · Progress in Biophysics and Molecular Biology
  49. Piezo ion channels: long-sought-after mechanosensors mediating hypertension and hypertensive nephropathy
    Takashi Nagase, Miki Nagase · 2024 · Hypertension Research
  50. Piezo1-induced durotaxis of pancreatic stellate cells depends on TRPC1 and TRPV4 channels
    Ilka Budde, André Schlichting, David Ing, Sandra Schimmelpfennig, Anna Kuntze, Benedikt Fels, Joelle M.-J. Romac, Sandip Madhusudan Swain, Rodger A. Liddle, Angela Stevens et al. · 2025 · Journal of Cell Science
  51. Shear stress activates monovalent cation channel transient receptor potential melastatin subfamily 4 in rat atrial myocytes via type 2 inositol 1,4,5‐trisphosphate receptors and Ca2+ release
    Min‐Jeong Son, Joon‐Chul Kim, Sung Woo Kim, Bojjibabu Chidipi, Muniyandi Jeyaraj, Thoudam Debraj Singh, Insuk So, Krishna Prasad Subedi, Sun‐Hee Woo · 2016 · The Journal of Physiology
  52. Infection-induced membrane ruffling initiates danger and immune signaling via the mechanosensor PIEZO1
    Lalitha Tadala, Dorothee Langenbach, Mirjam Dannborg, Ramón Cervantes-Rivera, Atin Sharma, Kevin Vieth, Lisa M. Rieckmann, Alkwin Wanders, David A. Cisneros, Andrea Puhar · 2022 · Cell Reports
  53. Impact of PIEZO1‐channel on inflammation and osteoclastogenesis mediated via periodontal ligament fibroblasts during mechanical loading
    Agnes Schröder, Katharina Neher, Bernhard Krenmayr, Eva Paddenberg, Gerrit Spanier, Peter Proff, Christian Kirschneck · 2023 · European Journal Of Oral Sciences
  54. Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi
    Sine Yaganoglu, Konstantinos Kalyviotis, Christina Vagena-Pantoula, Dörthe Jülich, Benjamin M. Gaub, Maaike Welling, Tatiana Lopes, Dariusz Lachowski, See Swee Tang, Armando E. del Río Hernández et al. · 2023 · Nature Communications
  55. Enhanced and sustained T cell activation in response to fluid shear stress
    Nicole S. Sarna, Shanay H. Desai, Benjamin G Kaufman, Natalie M Curry, Anne M Hanna, Michael R. King · 2024 · iScience
  56. Mechanotransductive Receptor Piezo1 as a Promising Target in the Treatment of Neurological Diseases
    Natalia Bryniarska, Andrzej Kubiak, Agnieszka Basta‐Kaim · 2022 · Current Neuropharmacology
  57. Piezo protein determines stem cell fate by transmitting mechanical signals
    Xiaolei Qiu, Zhuoyue Deng, Meijing Wang, Yuqi Feng, Lintao Bi, Lisha Li · 2022 · Human Cell
  58. Dual action of Dooku1 on PIEZO1 channel in human red blood cells
    Aline Hatem, Gwendal Poussereau, Martin Gachenot, Laurent Pérès, Guillaume Bouyer, Stéphane Égée · 2023 · Frontiers in Physiology
  59. Low-intensity pulsed ultrasound promotes the osteogenesis of mechanical force-treated periodontal ligament cells via Piezo1
    Fu Zheng, Tong Wu, Feifei Wang, Huazhi Li, Hongyi Tang, Xinyu Cui, Cuiying Li, Yixiang Wang, Jiuhui Jiang · 2024 · Frontiers in Bioengineering and Biotechnology
  60. The sensation of stretch
    Philip A. Gottlieb, Frederick Sachs · 2012 · Nature
  61. In vitro cell stretching technology (IsoStretcher) as an approach to unravel Piezo1-mediated cardiac mechanotransduction
    Yang Guo, Anna-Lena Merten, Ulrike Schöler, Ze‐Yan Yu, Jasmina Cvetkovska, Diane Fatkin, Michael Patrick Feneley, Boris Martinac, Oliver Friedrich · 2020 · Progress in Biophysics and Molecular Biology
  62. Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes
    Zhongcheng Liu, Yuchen Tang, Liangzhi He, Bin Geng, Fan Lü, Jinwen He, Qiong Yi, Xuening Liu, Kun Zhang, Lifu Wang et al. · 2022 · Channels
  63. Epithelial cells sense local stiffness via Piezo1 mediated cytoskeletal reorganization
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  64. Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue
    Cita Nottmeier, Josef Lavický, Marcos González‐López, Sarah Knauth, Bärbel Kahl‐Nieke, Michael Amling, Thorsten Schinke, Jill Ann Helms, Jan Křivánek, Till Koehne et al. · 2023 · Scientific Reports
  65. Role of mechanosensitive ion channel Piezo1 in tension-side orthodontic alveolar bone remodeling in rats
    Yugui Du, Kai Yang · 2023 · Archives of Oral Biology
  66. Rapid flow-induced activation of Gαq/11 is independent of Piezo1 activation
    Nathaniel G. dela Paz, John A. Frangos · 2019 · American Journal of Physiology-Cell Physiology
  67. Mechanical Stretch Triggers Epithelial-Mesenchymal Transition in Keratinocytes Through Piezo1 Channel
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  68. Activation of Piezo1 Increases Na,K-ATPase-Mediated Ion Transport in Mouse Lens
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  69. Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel
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  70. Human TMC1 and TMC2 are mechanically gated ion channels
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  71. Mechanical stretch-mediated fibroblast activation: The pivotal role of Piezo1 channels
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  72. Durotaxis Index of 3T3 Fibroblast Cells Scales with Stiff-to-Soft Membrane Tension Polarity
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  73. Endothelial Piezo1: Life depends on it
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  74. Essential Roles of PIEZO1 in Mammalian Cardiovascular System: From Development to Diseases
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  75. The Transient Receptor Potential Vanilloid Type 2 (TRPV2) Channel–A New Druggable Ca2+ Pathway in Red Cells, Implications for Red Cell Ion Homeostasis
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  76. Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells
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  77. A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement
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  78. Microglial Piezo1 mechanosensitive channel as a therapeutic target in Alzheimer’s disease
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  79. Piezo1 and tissue fibrosis: insights into its role and potential for modulation
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  80. Effects of Lys to Glu mutations in GsMTx4 on membrane binding, peptide orientation, and self-association propensity, as analyzed by molecular dynamics simulations
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  81. Channelizing the red blood cell: molecular biology competes with patch-clamp
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  82. The neuropeptide GsMTx4 inhibits a mechanosensitive BK channel through the voltage-dependent modification specific to mechano-gating
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  83. Active modulation of human erythrocyte mechanics
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  84. Different effects of GsMTx4 on nocturia associated with the circadian clock and Piezo1 expression in mice
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  91. Exploring the Multifactorial Regulation of PIEZO1 in Chondrocytes: Mechanisms and Implications
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  93. Piezo1: the key regulators in central nervous system diseases
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  94. Adherent cell remodeling on micropatterns is modulated by Piezo1 channels
    Deekshitha Jetta, Mohammad Reza Bahrani Fard, Frederick Sachs, Katie Munechika, Susan Z. Hua · 2021 · Scientific Reports
  95. Mechanosensing by Piezo1 and its implications in the kidney
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  98. Functional maturation of kidney organoid tubules: PIEZO1-mediated Ca2+ signaling
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