Determinants of cholesterol efflux capacity in humans

Talbot, Charlotte P.J.; Plat, Jogchum; Ritsch, Andreas; Mensink, Ronald P.

doi:10.1016/j.plipres.2017.12.001

Cited by 99Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthParaoxonase enzyme and polymorphisms

Determinants of cholesterol efflux capacity in humans

Talbot, Charlotte P.J., Plat, Jogchum, Ritsch, Andreas, Mensink, Ronald P.·2018·Progress in Lipid Research

DOI 10.1016/j.plipres.2017.12.001

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Abstract

High-density lipoproteins (HDL) play an important role in the reverse cholesterol transport (RCT) pathway, contributing to the efflux of excess cellular cholesterol. However, the classic hypothesis that raising HDL-cholesterol (HDL-C) concentrations reduces cardiovascular disease (CVD) risk has been challenged by recent intervention studies. Nowadays, improving cholesterol efflux capacity of HDL particles is considered to be a better target for the prevention of CVD. We will first briefly summarize assays that have been developed in order to quantify HDL-mediated cholesterol efflux from macrophages. However, the main purpose of this review is to discuss factors and ABC-transporters that are associated with HDL-mediated cholesterol efflux, such as HDL particle characteristics (i.e. HDL size and composition), subjects' characteristics (i.e. gender, BMI and age), HDL-C raising drugs, lifestyle, genetic background, as well as acute and low-grade systemic inflammation. Results suggested that factors associated with small HDL particles efficiently promote cholesterol efflux via the ABCA1 transporter. This appears to contradict findings from epidemiological studies suggesting that in particular large HDL 2 particles are related to a reduced CVD risk. It is therefore essential not only to understand targets to increase cholesterol efflux capacity, but also to prove causality between cholesterol efflux capacity and the prevention of CVD risk.

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Cholesterol can leave atherosclerotic plaque by three routes: efflux to HDL for blood return, emigration of foam cells carrying cholesterol, and efferocytosis of old foam cells by efflux-competent macrophages that may then leave the lesion.
“Three mechanisms are available for cholesterol removal from the atherosclerotic plaque (FIG. 3).”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [137]

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Can phosphatidylserine enhance atheroprotective activities of high-density lipoprotein?
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Cholesterol efflux analyses using stable isotopes and mass spectrometry
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The ability of plasma to stimulate fibroblast cholesterol efflux is associated with the −629C→A cholesteryl ester transfer protein promoter polymorphism: Role of lecithin:cholesterol acyltransferase activity
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Clinical trials with cholesteryl ester transfer protein inhibitors
Bartolo, B. A. D., Duong, M., & Nicholls, S. J. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000352 · Cited by 18 · see citing works
Basal and postprandial serum-promoted cholesterol efflux in normolipidemic subjects: Importance of fat mass distribution
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Effects of Simvastatin on the Phospholipid Composition of High-Density Lipoproteins in Patients with Hypercholesterolemia
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Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works
Molecular Pathways Underlying Cholesterol Homeostasis
Afonso, M., Machado, R., Lavrador, M. S., Quintão, E., Moore, K., & Lottenberg, A. M. (2018) · Nutrients · doi:10.3390/nu10060760 · Cited by 141 · see citing works
Brothers in Arms: ABCA1- and ABCG1-Mediated Cholesterol Efflux as Promising Targets in Cardiovascular Disease Treatment
Frambach, S. J. C. M., de Haas, R., Smeitink, J. A. M., Rongen, G. A. P. J. M., Rüssel, F. G. M., & Schirris, T. J. J. (2019) · Pharmacological Reviews · doi:10.1124/pr.119.017897 · Cited by 145 · see citing works
The ABC subfamily A transporters: Multifaceted players with incipient potentialities in cancer
Pasello, M., Giudice, A. M., & Scotlandi, K. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.10.004 · Cited by 131 · see citing works
Administration of Exogenous Melatonin Improves the Diurnal Rhythms of the Gut Microbiota in Mice Fed a High-Fat Diet
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Structure-function relationships of HDL in diabetes and coronary heart disease
Cardner, M., Yalçınkaya, M., Götze, S., Luca, E., Baláž, M., Hunjadi, M., Hartung, J., Shemet, A., Kränkel, N., Radosavljevic, S., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.131491 · Cited by 116 · see citing works
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LncRNA kcnq1ot1 promotes lipid accumulation and accelerates atherosclerosis via functioning as a ceRNA through the miR-452-3p/HDAC3/ABCA1 axis
Yu, X.-H., Deng, W., Chen, J., Xu, X., Liu, X.-X., Chen, L., Shi, M., Liu, Q.-X., Tao, M., & Ren, K. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03263-6 · Cited by 108 · see citing works
High Density Lipoprotein Cholesterol Efflux Capacity and Atherosclerosis in Cardiovascular Disease: Pathophysiological Aspects and Pharmacological Perspectives
Adorni, M. P., Ronda, N., Bernini, F., & Zimetti, F. (2021) · Cells · doi:10.3390/cells10030574 · Cited by 103 · see citing works
Effect of prebiotic (fructooligosaccharide) on uremic toxins of chronic kidney disease patients: a randomized controlled trial
Ramos, C. I., Armani, R. G., Canziani, M. E. F., Dalboni, M. A., Dolenga, C. J. R., Nakao, L. S., Campbell, K. L., & Cuppari, L. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy171 · Cited by 102 · see citing works
Diosgenin and Its Analogs: Potential Protective Agents Against Atherosclerosis
Wang, D., & Wang, X. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s368836 · Cited by 49 · see citing works
The Pathogenic Role of Long Non-coding RNA H19 in Atherosclerosis via the miR-146a-5p/ANGPTL4 Pathway
Huang, S.-F., Zhao, G., Peng, X., & Ye, W.-C. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.770163 · Cited by 48 · see citing works
From HDL-cholesterol to HDL-function: cholesterol efflux capacity determinants
Rhainds, D., & Tardif, J. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000589 · Cited by 45 · see citing works
High-Density Lipoprotein 3 Cholesterol and Primary Open-Angle Glaucoma
Nusinovici, S., Li, H., Thakur, S., Baskaran, M., Tham, Y. C., Zhou, L., Sabanayagam, C., Aung, T., Silver, D. L., Fan, Q., et al. (2021) · Ophthalmology · doi:10.1016/j.ophtha.2021.09.013 · Cited by 45 · see citing works
Knockdown of mesenchymal stem cell‑derived exosomal LOC100129516 suppresses the symptoms of atherosclerosis via upregulation of the PPARγ/LXRα/ABCA1 signaling pathway
Sun, L., He, X., Zhang, T., Han, Y., & Tao, G. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.5041 · Cited by 38 · see citing works
Lipid efflux mechanisms, relation to disease and potential therapeutic aspects
Castaño, D., Rattanasopa, C., Monteiro-Cardoso, V. F., Corlianò, M., Liu, Y., Zhong, A., Rusu, M., Liehn, E. A., & Singaraja, R. R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.04.013 · Cited by 37 · see citing works
Impact of NAFLD and its pharmacotherapy on lipid profile and CVD
Wang, Z., Ye, M., Zhang, X., Zhang, P., Cai, J., Li, H., & She, Z. (2022) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2022.07.010 · Cited by 37 · see citing works
HDL regulates the risk of cardiometabolic and inflammatory-related diseases: Focusing on cholesterol efflux capacity
Kang, H.-Y., Song, J., & Cheng, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112622 · Cited by 36 · see citing works
Asian age-related macular degeneration: from basic science research perspective
Yanagi, Y., Foo, V. H. X., & Yoshida, A. (2018) · Eye · doi:10.1038/s41433-018-0225-x · Cited by 35 · see citing works
Good Cholesterol Gone Bad? HDL and COVID-19
Kluck, G. E. G., Yoo, J., Sakarya, E. H., & Trigatti, B. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910182 · Cited by 34 · see citing works
Mendelian randomization analyses in ocular disease: a powerful approach to causal inference with human genetic data
Li, J., Li, C., Huang, Y., Guan, P., Huang, D., Yu, H., Yang, X., & Liu, L. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03822-9 · Cited by 33 · see citing works
High-Density Lipoprotein Function Is Reduced in Patients Affected by Genetic or Idiopathic Hypogonadism
Adorni, M. P., Zimetti, F., Cangiano, B., Vezzoli, V., Bernini, F., Caruso, D., Corsini, A., Sirtori, C. R., Cariboni, A. M., Bonomi, M., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02027 · Cited by 31 · see citing works
Assessment of HDL Cholesterol Removal Capacity: Toward Clinical Application
Toh, R. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv17028 · Cited by 30 · see citing works
Validation and application of a novel cholesterol efflux assay using immobilized liposomes as a substitute for cultured cells
Horiuchi, Y., Lai, S.-J., Yamazaki, A., Nakamura, A., Ohkawa, R., Yano, K., Kameda, T., Okubo, S., Shimano, S., Hagihara, M., et al. (2018) · Bioscience Reports · doi:10.1042/bsr20180144 · Cited by 28 · see citing works
Variants at the APOE/C1/C2/C4 Locus Modulate Cholesterol Efflux Capacity Independently of High‐Density Lipoprotein Cholesterol
Low‐Kam, C., Rhainds, D., Lo, K. S., Barhdadi, A., Boulé, M., Alem, S., Pedneault-Gagnon, V., Rhéaume, É., Dubé, M., Busseuil, D., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009545 · Cited by 28 · see citing works
Active polypeptides from Hirudo inhibit endothelial cell inflammation and macrophage foam cell formation by regulating the LOX-1/LXR-α/ABCA1 pathway
Lü, J., Chen, X., Xu, X., Liu, J., Zhang, Z., Wang, M., Li, X., Chen, H., Zhao, D., Wang, J., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108840 · Cited by 27 · see citing works
HDL-Mediated Lipid Influx to Endothelial Cells Contributes to Regulating Intercellular Adhesion Molecule (ICAM)-1 Expression and eNOS Phosphorylation
Muñoz‐Vega, M., Massó, F., Páez, A., Vargas‐Alarcón, G., Coral‐Vázquez, R. M., Mas‐Oliva, J., Carreón‐Torres, E., & Pérez-Méndez, O. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113394 · Cited by 26 · see citing works
Modification of High-Density Lipoprotein Functions by Diet and Other Lifestyle Changes: A Systematic Review of Randomized Controlled Trials
Sanllorente, A., Lassale, C. M., Soria-Florido, M. T., Castañer, O., Fitó, M., & Hernáez, Á. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245897 · Cited by 26 · see citing works
Effect of varying quantities of lean beef as part of a Mediterranean-style dietary pattern on lipids and lipoproteins: a randomized crossover controlled feeding trial.
Fleming, J. A., Kris-Etherton, P. M., Petersen, K. S., & Baer, D. J. (2021) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa375 · Cited by 25 · see citing works
SARS‐CoV‐2 induced HDL dysfunction may affect the host's response to and recovery from COVID‐19
Al-Kuraishy, H. M., Hussein, N. R., Al‐Niemi, M. S., Fahad, E. H., Albuhadily, A. K., Al-Gareeb, A. I., Al-Hamash, S. M., Tsagkaris, C., Papadakis, M., Alexiou, A. T., et al. (2023) · Immunity Inflammation and Disease · doi:10.1002/iid3.861 · Cited by 25 · see citing works
Whole egg consumption compared with yolk-free egg increases the cholesterol efflux capacity of high-density lipoproteins in overweight, postmenopausal women
Sawrey‐Kubicek, L., Zhu, C., Bardagjy, A. S., Rhodes, C. H., Sacchi, R., Randolph, J., Steinberg, F. M., & Zivkovic, A. M. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz088 · Cited by 25 · see citing works
A new method for measuring cholesterol efflux capacity uses stable isotope-labeled, not radioactive-labeled, cholesterol
Shimizu, T., Miyazaki, O., Iwamoto, T., Usui, T., Sato, R., Hiraishi, C., & Yoshida, H. (2019) · Journal of Lipid Research · doi:10.1194/jlr.d086884 · Cited by 23 · see citing works
High-density lipoprotein remodeling by phospholipid nanoparticles improves cholesterol efflux capacity and protects from atherosclerosis
Kudinov, V. A., Torkhovskaya, T. I., Zakharova, T. S., Morozevich, G. E., Artyushev, R. I., Zubareva, M., & Markin, S. S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111900 · Cited by 22 · see citing works
HDL Cholesterol Efflux Capacity is Impaired in Severe Short-Term Hypothyroidism Despite Increased HDL Cholesterol
van der Boom, T., Jia, C., Lefrandt, J. D., Connelly, M. A., Links, T. P., Tietge, U. J. F., & Dullaart, R. P. F. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa411 · Cited by 22 · see citing works
High-density lipoprotein cholesterol efflux capacity and cardiovascular risk in autoimmune and non-autoimmune diseases
Hafiane, A., Favari, E., Daskalopoulou, S. S., Vuilleumier, N., & Frias, M. A. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154141 · Cited by 21 · see citing works
Cholesterol efflux capacity and its association with prevalent metabolic syndrome in a multi-ethnic population (Dallas Heart Study)
Akinmolayemi, O., Saldanha, S., Joshi, P. H., Deodhar, S., Ayers, C. R., Neeland, I. J., & Rohatgi, A. K. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257574 · Cited by 20 · see citing works
Theobromine Does Not Affect Fasting and Postprandial HDL Cholesterol Efflux Capacity, While It Decreases Fasting miR‐92a Levels in Humans
Talbot, C. P. J., Mensink, R. P., Smolders, L., Bakeroot, V. L., & Plat, J. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800027 · Cited by 19 · see citing works
Self-citation
Cholesterol asymmetry at the tip of filopodia during cell adhesion
Kishimoto, T., Tomishige, N., Murate, M., Ishitsuka, R., Schaller, H., Mély, Y., Ueda, K., & Kobayashi, T. (2020) · The FASEB Journal · doi:10.1096/fj.201900065rr · Cited by 20 · see citing works
Direct Estimation of HDL-Mediated Cholesterol Efflux Capacity from Serum
Kuusisto, S. M., Holmes, M. V., Ohukainen, P., Kangas, A. J., Karsikas, M., Tiainen, M., Perola, M., Salomaa, V. V., Kettunen, J., & Ala‐Korpela, M. (2019) · Clinical Chemistry · doi:10.1373/clinchem.2018.299222 · Cited by 19 · see citing works
Cholesterol efflux capacity of large, small and total HDL particles is unaltered by atorvastatin in patients with type 2 diabetes
Muñóz-Hernández, L. L., Ortiz-Bautista, R. J., Brito-Córdova, G. X., Lozano-Arvizu, F., Saucedo, S., Pérez-Méndez, O. A., Zentella‐Dehesa, A., Dauteuille, C., Lhomme, M., Lesnik, P., et al. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.08.027 · Cited by 18 · see citing works
Infusions of Large Synthetic HDL Containing Trimeric apoA-I Stabilize Atherosclerotic Plaques in Hypercholesterolemic Rabbits
Parolini, C., Adorni, M. P., Busnelli, M., Manzini, S., Cipollari, E., Favari, E., Lorenzon, P., Ganzetti, G. S., Fingerle, J., Bernini, F., et al. (2019) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2019.05.033 · Cited by 18 · see citing works
An Increased Plasma Level of ApoCIII-Rich Electronegative High-Density Lipoprotein May Contribute to Cognitive Impairment in Alzheimer’s Disease
Chan, H., Ke, L., Lu, H.-T., Weng, S., Chan, H., Law, S., Lin, I., Chang, C., Lu, Y., Chen, C., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8120542 · Cited by 18 · see citing works
A novel therapeutic strategy for atherosclerosis: autophagy-dependent cholesterol efflux
Guo, H., Wei, D., Liu, R., Zhang, C., Jiang, S., Wang, W., Hu, H., Shen, L., & Liang, X. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00870-5 · Cited by 17 · see citing works
Predictive value of HDL function in patients with coronary artery disease: relationship with coronary plaque characteristics and clinical events
Magnoni, M., Andreini, D., Pirillo, A., Uboldi, P., Latini, R., Catapano, A. L., Maggioni, A. P., Norata, G. D., & on behalf of the CAPIRE Study Group (2022) · Annals of Medicine · doi:10.1080/07853890.2022.2063374 · Cited by 17 · see citing works
A Compendium of the Biological Effects of Apolipoprotein A-IMilano
Parolini, C. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.261719 · Cited by 16 · see citing works
HAND2-AS1 targeting miR-1208/SIRT1 axis alleviates foam cell formation in atherosclerosis
Ma, L., He, S., Li, H., Zhang, S., & Yin, Y. (2021) · International Journal of Cardiology · doi:10.1016/j.ijcard.2021.11.019 · Cited by 14 · see citing works
Associations of ABCG1-mediated cholesterol efflux capacity with coronary artery lipid content assessed by near-infrared spectroscopy
Takata, K., Honda, S., Sidharta, S. L., Duong, M., Shishikura, D., Kim, S. W., Andrews, J., Bartolo, B. A. D., Psaltis, P. J., Bursill, C. A., et al. (2019) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt.2018.11.04 · Cited by 14 · see citing works
E3317 promotes cholesterol efflux in macrophage cells via enhancing ABCA1 expression
Wang, X., Luo, J., Li, N., Liu, L., Han, X., Liu, C., Zuo, X., Jiang, X., Li, Y., Xu, Y., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.08.125 · Cited by 13 · see citing works
MicroRNA ‐328‐5p Alleviates Macrophage Lipid Accumulation through the Histone Deacetylase 3/ATP‐binding cassette transporter A1 pathway
Huang, J., Jiang, X., Li, Z., & Jiang, C. (2021) · Lipids · doi:10.1002/lipd.12297 · Cited by 12 · see citing works
The Relationship between Complements and Age-Related Macular Degeneration and Its Pathogenesis
Chu, L., Bi, C., Wang, C., & Zhou, H. (2024) · Journal of Ophthalmology · doi:10.1155/2024/6416773 · Cited by 10 · see citing works
Substrate Stiffness Regulates Cholesterol Efflux in Smooth Muscle Cells
Mao, X., Tan, Y., Wang, H., Li, S., & Zhou, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.648715 · Cited by 10 · see citing works
Role of lipoprotein structure and dynamics in disease development
M., Y. Y. C. (2023) · doi:10.24834/isbn.9789178773978 · Cited by 9 · see citing works
Associations between neighborhood socioeconomic deprivation, IFNγ, and high-density lipoprotein particle size: Data from the Washington, D.C. cardiovascular health and needs assessment
Ortiz-Whittingham, L. R., Baumer, Y., Pang, A. P. S., Sampson, M. L., Baez, A. S., Rose, R., Noonan, S. B., Mendez-Silva, J., Collins, B. S., Mitchell, V. M., et al. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106346 · Cited by 9 · see citing works
History and development of ABCA1.
Wang, Y., Guo, M., & Tang, C.-K. (2023) · Current problems in cardiology · doi:10.1016/j.cpcardiol.2023.102036 · Cited by 9 · see citing works
Khat Chewing and Lipid Profile in Human and Experimental Animals
Al-Duais, M. A., & Al-Awthan, Y. S. (2021) · BioMed Research International · doi:10.1155/2021/6001885 · Cited by 8 · see citing works
Contributions of Lipid-Related Metabolites and Complement Proteins to Early and Intermediate Age-Related Macular Degeneration
Nusinovici, S., Zhou, L., Wang, X., Tham, Y. C., Wang, X., Wong, T. Y., Chakravarthy, U., & Cheng, C. (2024) · Ophthalmology Science · doi:10.1016/j.xops.2024.100538 · Cited by 8 · see citing works
Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna
Constantinou, J. K., Southam, A. D., Kvist, J., Jones, M. R., Viant, M. R., & Mirbahai, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-62476-z · Cited by 8 · see citing works
Additive Effects of Drinking Habits and a Susceptible Genetic Polymorphism on Cholesterol Efflux Capacity
Matsumoto, E., Oniki, K., Ota-Kontani, A., Seguchi, Y., Sakamoto, Y., Kaneko, T., Imafuku, T., Maeda, H., Watanabe, H., Maruyama, T., et al. (2022) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.63277 · Cited by 8 · see citing works
High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner
Correa, Y., Giudice, R. D., Waldie, S., Thépaut, M., Micciula, S., Gerelli, Y., Moulin, M., Delaunay, C., Fieschi, F., Pichler, H., et al. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.04.137 · Cited by 8 · see citing works
Statins influence the relationship between ATP-binding cassette A1 membrane transporter-mediated cholesterol efflux capacity and coronary atherosclerosis in rheumatoid arthritis
Karpouzas, G. A., Papotti, B., Ormseth, S. R., Palumbo, M., Hernández, E., Adorni, M. P., Zimetti, F., Budoff, M. J., & Ronda, N. (2023) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2023.100206 · Cited by 8 · see citing works
The association between the uric acid to high-density lipoprotein cholesterol ratio (UHR) index and obesity in postmenopausal women: a cross-sectional analysis based on the NHANES
Tian, J., Huang, Y., Xiao, Z., Yuan, S., Ma, S., Zhao, X., & Liu, Y. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02715-2 · Cited by 9 · see citing works
Impaired Cholesterol Efflux Capacity rather than Low HDL-C Reflects Oxidative Stress under Acute Myocardial Infarction
Oniki, K., Ogura, M., Matsumoto, E., Watanabe, H., Imafuku, T., Seguchi, Y., Arima, Y., Fujisue, K., Yamanaga, K., Yamamoto, E., et al. (2024) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.64691 · Cited by 7 · see citing works
Opuntia dillenii Haw. Polysaccharide Promotes Cholesterol Efflux in THP-1-Derived Foam Cells via the PPARγ-LXRα Signaling Pathway
Li, H., Huang, Z., & Zeng, F. (2022) · Molecules · doi:10.3390/molecules27248639 · Cited by 7 · see citing works
High Density Lipoproteins Phosphatidylcholine as a Regulator of Reverse Cholesterol Transport
Torkhovskaya, T. I., Kudinov, V. A., Zakharova, T. S., Ipatova, O. M., & Markin, S. S. (2018) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162018060092 · Cited by 7 · see citing works
Annexin A6 Polymorphism Is Associated with Pro-atherogenic Lipid Profiles and with the Downregulation of Methotrexate on Anti-Atherogenic Lipid Profiles in Psoriasis
Zhang, F., Han, L., Wang, B., Huang, Q., Yawalkar, N., Zhang, Z., & Yan, K. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11237059 · Cited by 6 · see citing works
Metabolomic Profiling of Cholesterol Efflux Capacity in a Multiethnic Population: Insights From MESA
Hunter, W. G., Smith, A., Pinto, R. C., Saldanha, S., Gangwar, A., Pahlavani, M., Deodhar, S., Wilkins, J. T., Pandey, A., Herrington, D. M., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318222 · Cited by 6 · see citing works
Combined Effect of Diosgenin Along with Ezetimibe or Atorvastatin on the Fate of Labelled Bile Acid and Cholesterol in Hypercholesterolemic Rats
Marín-Medina, A., Ruíz-Hidalgo, G., Blé‐Castillo, J. L., Zetina‐Esquivel, A. M., Zamora, R. M., Juárez‐Rojop, I. E., & Díaz-Zagoya, J. C. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16040627 · Cited by 6 · see citing works
Serum Cholesterol Efflux Capacity in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy
Yanagi, Y., Yu, R. M. C., Shihabuddeen, W. A., Yu, M., Teo, K. Y. C., Tan, A. C. S., Cheng, C., Wong, T. Y., Apte, R. S., & Cheung, C. M. G. (2022) · Ophthalmology Science · doi:10.1016/j.xops.2022.100142 · Cited by 5 · see citing works
Development and validation of a nomogram-based risk prediction model for non-alcoholic fatty liver disease (NAFLD): a logistic regression analysis in a physical examination population
Lan, J. Q., Que, T., Lan, H., Zhang, M., & Ban, L. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-04115-3 · Cited by 5 · see citing works
Effects of Longer-Term Mixed Nut Consumption on Lipoprotein Particle Concentrations in Older Adults with Overweight or Obesity
Nijssen, K. M. R., Chavez-Alfaro, M. A., Joris, P. J., Plat, J., & Mensink, R. P. (2024) · Nutrients · doi:10.3390/nu17010008 · Cited by 5 · see citing works
Self-citation
Cholesterol Efflux Capacity and Anti-Oxidative Activity of High-Density Lipoprotein in Chronic Kidney Disease
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Authors: Talbot, C. P. J., Plat, J., Ritsch, A., & Mensink, R. P.
Affiliations: Maastricht University (NL)
Innsbruck Medical University (AT)
Corresponding author: Mensink, Ronald P.
ORCID: Plat, Jogchum
Ritsch, Andreas
Mensink, Ronald P.
Venue: Progress in Lipid Research
Publisher: Elsevier BV
Published: 2018-01
Volume: 69
Pages: 21-32
ISSN: 0163-7827 (ISSN-L)
DOI: 10.1016/j.plipres.2017.12.001
OpenAlex: W2780738847
Cited by: 99
References: 157
Citations by year: 2026: 5 · 2025: 7 · 2024: 8 · 2023: 11 · 2022: 15 · 2021: 16 · 2020: 10 · 2019: 15 · 2018: 11 · 2014: 1
FWCI: 2.09
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Lipid Research (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion)
Research Publications (Maastricht University) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: cholesterol efflux capacity, HDL cholesterol, reverse cholesterol transport, HDL particle size, ABC transporters, macrophages, cardiovascular risk, lifestyle factors, genetic background, low-grade inflammation
MeSH terms: Hypolipidemic Agents, Biological Transport, Cholesterol, Humans, Cholesterol, HDL

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Determinants of cholesterol efflux capacity in humans

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