Possible Role of Liver Cytosolic and Mitochondrial Aldehyde Dehydrogenases in Acetaldehyde Metabolism

ALDEHYDE DEHYDROGENASE DEFICIENCY AS CAUSE OF FACIAL FLUSHING REACTION TO ALCOHOL IN JAPANESE

Harada, S., Agarwal, D. P., & GOEDDE, H. W. (1981) · The Lancet · doi:10.1016/s0140-6736(81)91172-7 · Cited by 546 · see citing works

Horse Liver Aldehyde Dehydrogenase

Feldman, R. I., & Weiner, H. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45784-0 · Cited by 209 · see citing works

Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase.

Farrés, J., Wang, X., Takahashi, K., Cunningham, S. J., Wang, T. T., & Weiner, H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36725-x · Cited by 148 · see citing works

Horse liver aldehyde dehydrogenase. Purification and characterization of two isozymes.

Eckfeldt, J. H., Mope, L., Takio, K., & Yonetani, T. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33950-9 · Cited by 123 · see citing works

Isolation and characterization of aldehyde dehydrogenase isozymes from usual and atypical human livers.

Ikawa, M., Impraim, C. C., Wang, G., & Yoshida, A. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32405-0 · Cited by 119 · see citing works

Human aldehyde dehydrogenase. Activity with aldehyde metabolites of monoamines, diamines, and polyamines

Ambroziak, W., & Pietruszko, R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98796-x · Cited by 102 · see citing works

Primary structures of rat and bovine liver mitochondrial aldehyde dehydrogenases deduced from cDNA sequences

Farrés, J., Guan, K., & Weiner, H. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb14616.x · Cited by 95 · see citing works

An Electron Transport Particle from Yeast: Purification and Properties

Mackler, B. F., Collipp, P. J., Duncan, H. M., Rao, N. A., & Huennekens, F. M. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60258-3 · Cited by 79 · see citing works

Aldehyde dehydrogenase activity as the rate-limiting factor for acetaldehyde metabolism in rat liver

Svanas, G. W., & Weiner, H. (1985) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(85)90603-4 · Cited by 68 · see citing works

Kinetic mechanism of the human cytoplasmic aldehyde dehydrogenase E1

Vallari, R. C., & Pietruszko, R. (1981) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(81)90338-6 · Cited by 54 · see citing works

The use of pH-gradient ion-exchange chromatography to separate sheep liver cytoplasmic aldehyde dehydrogenase from mitochondrial enzyme contamination, and observations on the interaction between the pure cytoplasmic enzyme and disulfiram

Dickinson, F. M., Hart, G. J., & Kitson, T. M. (1981) · Biochemical Journal · doi:10.1042/bj1990573 · Cited by 50 · see citing works

S-Methyl N,N-diethylthiocarbamate sulfone, a potential metabolite of disulfiram and potent inhibitor of low Km mitochondrial aldehyde dehydrogenase

Mays, D. C., Nelson, A. N., Fauq, A. H., Shriver, Z. H., Veverka, K. A., Naylor, S., & Lipsky, J. J. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)00504-f · Cited by 35 · see citing works

Human mitochondrial aldehyde dehydrogenase inhibition by diethyldithiocarbamic acid methanethiol mixed disulfide: a derivative of disulfiram

MacKerell, A. D., Vallari, R. C., & Pietruszko, R. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80195-2 · Cited by 35 · see citing works

Further studies of the action of disulfiram and 2,2′-dithiodipyridine on the dehydrogenase and esterase activities of sheep liver cytoplasmic aldehyde dehydrogenase

Kitson, T. M. (1982) · Biochemical Journal · doi:10.1042/bj2030743 · Cited by 32 · see citing works

Mouse mitochondrial aldehyde dehydrogenase isozymes: Purification and molecular properties

Algar, E. M., & Holmes, R. S. (1985) · International Journal of Biochemistry · doi:10.1016/0020-711x(85)90085-0 · Cited by 25 · see citing works

Human liver aldehyde dehydrogenases: new method of purification of the major mitochondrial and cytosolic enzymes and re-evaluation of their kinetic properties

Rashkovetsky, L. G., Maret, W., & Klyosov, A. A. (1994) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(94)90249-6 · Cited by 22 · see citing works

Purification of aldehyde dehydrogenase from rat liver mitochondria by α-cyanocinnamate affinity chromatography

Poole, R. C., & Halestrap, A. P. (1989) · Biochemical Journal · doi:10.1042/bj2590105 · Cited by 20 · see citing works

Developmental profile of hepatic alcohol and aldehyde dehydrogenase activities in long-sleep and short-sleep mice

Smolen, T. N., Smolen, A., & van de Kamp, J. L. (1990) · Alcohol · doi:10.1016/0741-8329(90)90062-h · Cited by 17 · see citing works

Initial Characterization of Aldehyde Dehydrogenase from Rat Testis Cytosol

BEDINO, S., Testore, G., & Obert, F. (1990) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1990.371.1.95 · Cited by 17 · see citing works

Studies on the mechanism of sheep liver cytosolic aldehyde dehydrogenase. The effect of pH on the aldehyde binding reactions and a re-examination of the problem of the site of proton release in the mechanism

Dickinson, F. M. (1986) · Biochemical Journal · doi:10.1042/bj2380075 · Cited by 14 · see citing works

Steady-state and pre-steady-state kinetics of propionaldehyde oxidation by sheep liver cytosolic aldehyde dehydrogenase at pH 5.2. Evidence that the release of NADH remains rate-limiting in the enzyme mechanism at acid pH values

Hill, J. P., Blackwell, L. F., Buckley, P. D., & Motion, R. L. (1991) · Biochemistry · doi:10.1021/bi00219a032 · Cited by 7 · see citing works

Modification of aldehyde dehydrogenase with dicyclohexylcarbodiimide: Separation of dehydrogenase from esterase activity

Abriola, D. P., & Pietruszko, R. (1992) · Journal of Protein Chemistry · doi:10.1007/bf01025093 · Cited by 7 · see citing works

Regulation by progesterone and pregnenolone of dimeric aldehyde dehydrogenase from rat testis cytoplasm

BEDINO, S., & Testore, G. (1993) · International Journal of Biochemistry · doi:10.1016/0020-711x(93)90591-2 · Cited by 3 · see citing works

Aldehyde Dehydrogenase

(2021) · doi:10.31003/uspnf_r1959_01_01 · Cited by 2 · see citing works

Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily

Marchitti, S. A., Brocker, C. N., Stagos, D., & Vasiliou, V. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.6.697 · Cited by 806 · see citing works

Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstress

Singh, S. P., Brocker, C. N., Koppaka, V., Chen, Y., Jackson, B. C., Matsumoto, A., Thompson, D. C., & Vasiliou, V. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.010 · Cited by 634 · see citing works

Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities

Chen, C., Ferreira, J. C. B., Gross, E. R., & Mochly‐Rosen, D. (2014) · Physiological Reviews · doi:10.1152/physrev.00017.2013 · Cited by 613 · see citing works

Pancreatic cancer: A review of epidemiology, trend, and risk factors

Hu, J.-X., Zhao, C., Chen, W.-B., Liu, Q., Li, Q.-W., Lin, Y., & Gao, F. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i27.4298 · Cited by 602 · see citing works

Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury

Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works

Fanconi anaemia and cancer: an intricate relationship

Nalepa, G., & Clapp, D. W. (2018) · Nature reviews. Cancer · doi:10.1038/nrc.2017.116 · Cited by 388 · see citing works

Impaired dopamine metabolism in Parkinson’s disease pathogenesis

Masato, A., Plotegher, N., Boassa, D., & Bubacco, L. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0332-6 · Cited by 331 · see citing works

Human aldehyde dehydrogenases: Potential pathological, pharmacological, and toxicological impact

Sládek, N. E. (2003) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.10057 · Cited by 263 · see citing works

ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective

Chang, J. S.-M., Hsiao, J., & Chen, C. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0327-y · Cited by 225 · see citing works

Mitochondrial aldehyde dehydrogenase and cardiac diseases

Chen, C., Sun, L., & Mochly‐Rosen, D. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq192 · Cited by 210 · see citing works

Sheep liver cytosolic aldehyde dehydrogenase: the structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases

Moore, S. A., Baker, H. M., Blythe, T. J., Kitson, K. E., Kitson, T. M., & Baker, E. N. (1998) · Structure · doi:10.1016/s0969-2126(98)00152-x · Cited by 199 · see citing works

The Biochemistry of Drug Metabolism – An Introduction

Testa, B., & Krämer, S. D. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790032 · Cited by 177 · see citing works

GLYOXYLATE SYNTHESIS, AND ITS MODULATION AND INFLUENCE ON OXALATE SYNTHESIS

Holmes, R. P., & Assimos, D. G. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)62363-2 · Cited by 168 · see citing works

Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin

Li, Y. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26564 · Cited by 168 · see citing works

Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse

Kitagawa, K., Kawamoto, T., Kunugita, N., Tsukiyama, T., Okamoto, K., Yoshida, A., Nakayama, K., & Nakayama, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01710-5 · Cited by 159 · see citing works

Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term

Mittal, P., Romero, R. J., Tarca, A. L., Gonzalez, J., Drăghici, S., Xu, Y., Dong, Z., Nhan‐Chang, C., Chaiworapongsa, T., Lye, S. J., et al. (2010) · Journal of Perinatal Medicine · doi:10.1515/jpm.2010.097 · Cited by 151 · see citing works

Profiling the specific reactivity of the proteome with non-directed activity-based probes

Adam, G. C., Cravatt, B. F., & Sorensen, E. J. (2001) · Chemistry & Biology · doi:10.1016/s1074-5521(00)90060-7 · Cited by 150 · see citing works

Genes encoding enzymes involved in ethanol metabolism

Hurley, T. (2012) · Alcohol Research: Current Reviews · doi:10.35946/arcr.v34.3.09 · Cited by 145 · see citing works

Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme

Stagos, D., Chen, Y., Brocker, C. N., Donald, E., Jackson, B. C., Orlicky, D. J., Thompson, D. C., & Vasiliou, V. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.034678 · Cited by 142 · see citing works

Effects of Oxidative Alcohol Metabolism on the Mitochondrial Permeability Transition Pore and Necrosis in a Mouse Model of Alcoholic Pancreatitis

Shalbuyeva, N., Mareninova, O. A., Gerloff, A., Yuan, J., Waldron, R. T., Pandol, S. J., & Gukovskaya, A. S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.10.037 · Cited by 131 · see citing works

Role of CYP2E1 in Mitochondrial Dysfunction and Hepatic Injury by Alcohol and Non-Alcoholic Substances

Abdelmegeed, M. A., Ha, S.-K., Choi, Y., Akbar, M. D., & Song, B. (2017) · Current Molecular Pharmacology · doi:10.2174/1874467208666150817111114 · Cited by 102 · see citing works

The Effect of Ethanol and Its Metabolites Upon Methionine Synthase Activity In Vitro

Kenyon, S. H., Nicolaou, A., & Gibbons, W. A. (1998) · Alcohol · doi:10.1016/s0741-8329(97)00134-1 · Cited by 100 · see citing works

Characterization of Two Distinct Structural Classes of Selective Aldehyde Dehydrogenase 1A1 Inhibitors

Morgan, C. A., & Hurley, T. D. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501900s · Cited by 99 · see citing works

Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD+ and retinoic acid

Moretti, A., Li, J., Donini, S., Sobol, R. W., Rizzi, M., & Garavaglia, S. (2016) · Scientific Reports · doi:10.1038/srep35710 · Cited by 96 · see citing works

Plant derivatives in the treatment of alcohol dependency

Rezvani, A. H., Overstreet, D. H., Perfumi, M. C., & Massi, M. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00124-2 · Cited by 94 · see citing works

Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol

Matsuda, T., Matsumoto, A., Uchida, M., Kanaly, R. A., Misaki, K., Shibutani, S., Kawamoto, T., Kitagawa, K., Nakayama, K. I., Tomokuni, K., et al. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm057 · Cited by 88 · see citing works

Ocular aldehyde dehydrogenases: Protection against ultraviolet damage and maintenance of transparency for vision

Chen, Y., Thompson, D. C., Koppaka, V., Jester, J. V., & Vasiliou, V. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.10.001 · Cited by 88 · see citing works

Characterization of superoxide production from aldehyde oxidase: An important source of oxidants in biological tissues

Kundu, T. K., Hille, R., Velayutham, M., & Zweier, J. L. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.12.032 · Cited by 83 · see citing works

Identification of the Cytochrome P450 and Other Enzymes Involved in the In Vitro Oxidative Metabolism of a Novel Antidepressant, Lu AA21004

Hvenegaard, M. G., Bang‐Andersen, B., Pedersen, H., Jørgensen, M., Püschl, A., & Dalgaard, L. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.044610 · Cited by 83 · see citing works

Nitroglycerin Use in Myocardial Infarction Patients - Risks and Benefits -

Ferreira, J. C. B., & Mochly‐Rosen, D. (2011) · Circulation Journal · doi:10.1253/circj.cj-11-1133 · Cited by 81 · see citing works

Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters

Keung, W. M., Klyosov, A. A., & Vallée, B. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1675 · Cited by 76 · see citing works

Pathogenesis of alcoholic liver disease: the role of nuclear receptors

Gyamfi, M. A., & Wan, Y. Y. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2009.009249 · Cited by 74 · see citing works

Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications

Song, B.-J., Abdelmegeed, M. A., Yoo, S.-H., Kim, B.-J., Jo, S. A., Jo, I., & Moon, K.-H. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.05.013 · Cited by 73 · see citing works

Aldehyde Dehydrogenase (CoA-Acetylating) and the Mechanism of Ethanol Formation in the Amitochondriate Protist,Giardia lamblia

Sánchez, L. B. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0664 · Cited by 73 · see citing works

Maternal Aldehyde Elimination during Pregnancy Preserves the Fetal Genome

Oberbeck, N., Langevin, F., King, G., de Wind, N., Crossan, G. P., & Patel, K. J. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.07.010 · Cited by 72 · see citing works

Bioactivation of Nitroglycerin by Purified Mitochondrial and Cytosolic Aldehyde Dehydrogenases

Beretta, M., Gruber, K. F., Kollau, A., Russwurm, M., Koesling, D., Goessler, W., Keung, W. M., Schmidt, K., & Mayer, B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801182200 · Cited by 72 · see citing works

Structural shifts of aldehyde dehydrogenase enzymes were instrumental for the early evolution of retinoid-dependent axial patterning in metazoans

Sobreira, T. J. P., Marlétaz, F., Simões-Costa, M., Schechtman, D., Pereira, A. C., Brunet, F., Sweeney, S., Pani, A. M., Aronowicz, J., Lowe, C. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011223108 · Cited by 69 · see citing works

Inhibition of Recombinant Human Mitochondrial and Cytosolic Aldehyde Dehydrogenases by Two Candidates for the Active Metabolites of Disulfiram

Lam, J. P., Mays, D. C., & Lipsky, J. J. (1997) · Biochemistry · doi:10.1021/bi970948e · Cited by 69 · see citing works

Increased nitroxidative stress promotes mitochondrial dysfunction in alcoholic and nonalcoholic fatty liver disease

Song, B.-J., Abdelmegeed, M. A., Henderson, L. E., Yoo, S.-H., Wan, J., Purohit, V., Hardwick, J. P., & Moon, K.-H. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/781050 · Cited by 67 · see citing works

Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity

Shabtai, Y., Bendelac-Kapon, L., Jubran, H., Hirschberg, J., & Fainsod, A. (2018) · Scientific Reports · doi:10.1038/s41598-017-18719-7 · Cited by 66 · see citing works

Mitochondrially-targeted treatment strategies

Bozi, L. H. M., Campos, J. C., Zambelli, V. O., Ferreira, N. D., & Ferreira, J. C. B. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.100836 · Cited by 65 · see citing works

Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis

Johnson, C. H., Golla, J. P., Dioletis, E., Singh, S. P., Ishii, M., Charkoftaki, G., Thompson, D. C., & Vasiliou, V. (2021) · Cancers · doi:10.3390/cancers13174404 · Cited by 65 · see citing works

Endogenous ethanol production in health and disease

Meijnikman, A. S., Nieuwdorp, M., & Schnabl, B. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00937-w · Cited by 65 · see citing works

Inhibition of the oxidative metabolism of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine metabolism, by 4-hydroxy-2-nonenal

Florang, V. R., Rees, J., Brogden, N. K., Anderson, D. G., Hurley, T. D., & Doorn, J. A. (2006) · NeuroToxicology · doi:10.1016/j.neuro.2006.07.018 · Cited by 62 · see citing works

Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update

Rosello, A. P., López, A., Folch‐Puy, E., Carbonell, T., Rolo, A. P., Palmeira, C. M., Adam, R. A., Net, M., & Roselló‐Catafau, J. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i27.2984 · Cited by 61 · see citing works

Evaluation of Aldehyde Dehydrogenase 1 Promoter Polymorphisms Identified in Human Populations

Spence, J. P., Liang, T., Eriksson, C. J. P., Taylor, R. E., Wall, T. L., Ehlers, C. L., & Carr, L. G. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000087086.50089.59 · Cited by 60 · see citing works

Mitochondria and Angiogenesis

Marcu, R., Zheng, Y. Y., & Hawkins, B. J. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_21 · Cited by 59 · see citing works

Alcohol and breast cancer

Starek‐Świechowicz, B., Budziszewska, B., & Starek, A. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00426-4 · Cited by 57 · see citing works

Acute and chronic ethanol exposure differentially alters alcohol dehydrogenase and aldehyde dehydrogenase activity in the zebrafish liver

Tran, S., Nowicki, M., Chatterjee, D., & Gerlai, R. T. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.09.011 · Cited by 57 · see citing works

De Novo-Synthesized Retinoic Acid in Ovarian Antral Follicles Enhances FSH-Mediated Ovarian Follicular Cell Differentiation and Female Fertility

Kawai, T., Yanaka, N., Richards, J. S., & Shimada, M. (2016) · Endocrinology · doi:10.1210/en.2015-2064 · Cited by 57 · see citing works

Pueraria lobata (Kudzu root) hangover remedies and acetaldehyde-associated neoplasm risk

McGregor, N. (2007) · Alcohol · doi:10.1016/j.alcohol.2007.07.009 · Cited by 56 · see citing works

A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators

Chang, Y., Lee, H.-L., Yang, W., Hsieh, M.-L., Liu, C.-C., Lee, T.-Y., Huang, J., Nong, J., Li, F., Chuang, H.-L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41570-6 · Cited by 55 · see citing works

Increased formation of gastric N2-ethylidene-2′-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol

Nagayoshi, H., Matsumoto, A., Nishi, R., Kawamoto, T., Ichiba, M., & Matsuda, T. (2008) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.11.009 · Cited by 53 · see citing works

MOLECULAR CLONING, BACULOVIRUS EXPRESSION, AND TISSUE DISTRIBUTION OF THE ZEBRAFISH ALDEHYDE DEHYDROGENASE 2

Lassen, N., Estey, T., Tanguay, R. L., Pappa, A., Reimers, M. J., & Vasiliou, V. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.002964 · Cited by 51 · see citing works

Characterization of the East Asian Variant of Aldehyde Dehydrogenase-2

Beretta, M., Gorren, A. C. F., Wenzl, M. V., Weis, R., Russwurm, M., Koesling, D., Schmidt, K., & Mayer, B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.014548 · Cited by 51 · see citing works

Herbal Remedies for Alcoholism: Promises and Possible Pitfalls

Overstreet, D. H., Keung, W., Rezvani, A. H., Massi, M., & Lee, D. Y. W. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000051022.26489.cf · Cited by 51 · see citing works

Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease

Song, B., Akbar, M. D., Jo, I., Hardwick, J. P., & Abdelmegeed, M. A. (2015) · Advances in pharmacology · doi:10.1016/bs.apha.2015.04.002 · Cited by 49 · see citing works

The Influence of Genetic Polymorphisms on Population Variability in Six Xenobiotic-Metabolizing Enzymes

Ginsberg, G., Smolenski, S., Neafsey, P. J., Hattis, D. B., Walker, K., Guyton, K. Z., Johns, D. O., & Sonawane, B. R. (2009) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937400903158318 · Cited by 49 · see citing works

Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives

Buchman, C. D., & Hurley, T. D. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01825 · Cited by 47 · see citing works

Ethyltertiary-Butyl Ether: A Toxicological Review

McGregor, D. B. (2007) · Critical Reviews in Toxicology · doi:10.1080/10408440601177723 · Cited by 46 · see citing works

Developmental Expression of Aldehyde Dehydrogenase in Rat: a Comparison of Liver and Lung Development

Yoon, M., Madden, M. C., & Barton, H. A. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfj045 · Cited by 46 · see citing works

Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway

Chen, Y., Singh, S. P., Matsumoto, A., Manna, S., Abdelmegeed, M. A., Golla, S., Murphy, R. C., Dong, H., Song, B., Gonzalez, F. J., et al. (2016) · Scientific Reports · doi:10.1038/srep29743 · Cited by 46 · see citing works

Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium

Amanuma, Y., Ohashi, S., Itatani, Y., Tsurumaki, M., Matsuda, S., Kikuchi, O., Nakai, Y., Miyamoto, S., Oyama, T., Kawamoto, T., et al. (2015) · Scientific Reports · doi:10.1038/srep14142 · Cited by 45 · see citing works

Is nonalcoholic fatty liver disease an endogenous alcoholic fatty liver disease? – A mechanistic hypothesis

de Medeiros, I. C., & Lima, J. G. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.04.021 · Cited by 43 · see citing works

The Role of Retinoid X Receptor α in Regulating Alcohol Metabolism

Gyamfi, M. A., Kocsis, M. G., He, L., Dai, G., Mendy, A. J., & Wan, Y. Y. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.108175 · Cited by 42 · see citing works

Anti‐dipsotropic isoflavones: The potential therapeutic agents for alcohol dependence

Keung, W. M. (2003) · Medicinal Research Reviews · doi:10.1002/med.10049 · Cited by 42 · see citing works

Glu504Lys Single Nucleotide Polymorphism of Aldehyde Dehydrogenase 2 Gene and the Risk of Human Diseases

Zhao, Y., & Wang, C. (2015) · BioMed Research International · doi:10.1155/2015/174050 · Cited by 41 · see citing works

Aldehyde dehydrogenase-2 transgene ameliorates chronic alcohol ingestion-induced apoptosis in cerebral cortex

Ren, J. T., Babcock, S. A., Li, Q., Huff, A. F., Li, S., & Doser, T. A. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.02.019 · Cited by 40 · see citing works

Inactivation of cytosolic aldehyde dehydrogenase viaS‐nitrosylation in ethanol‐exposed rat liver

Moon, K., Abdelmegeed, M. A., & Song, B. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.07.037 · Cited by 39 · see citing works

Vascular Bioactivation of Nitroglycerin by Aldehyde Dehydrogenase-2

Lang, B., Gorren, A. C. F., Oberdorfer, G., Wenzl, M. V., Furdui, C. M., Poole, L. B., Mayer, B., & Gruber, K. F. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.371716 · Cited by 39 · see citing works

Gene Therapy Correction of Aldehyde Dehydrogenase 2 Deficiency

Matsumura, Y., Stiles, K. M., Reid, J., Frenk, E. Z., Cronin, S., Pagovich, O. E., & Crystal, R. G. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.08.004 · Cited by 39 · see citing works

Partially Irreversible Inactivation of Mitochondrial Aldehyde Dehydrogenase by Nitroglycerin

Beretta, M., Sottler, A., Schmidt, K., Mayer, B., & Gorren, A. C. F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804001200 · Cited by 39 · see citing works

ALDH2 polymorphism and myocardial infarction: From alcohol metabolism to redox regulation

Lamb, R. J., Griffiths, K., Lip, G. Y. H., Sorokin, V. A., Frenneaux, M. P., Feelisch, M., & Madhani, M. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108666 · Cited by 38 · see citing works

A missense single nucleotide polymorphism in the ALDH2 gene, rs671, is associated with hip fracture

Takeshima, K., Nishiwaki, Y., Suda, Y., Niki, Y., Sato, Y., Kobayashi, T., Miyamoto, K., Uchida, H., Inokuchi, W., Tsuji, T., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00503-2 · Cited by 38 · see citing works

A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells

Li, J., Garavaglia, S., Ye, Z., Moretti, A., Belyaeva, O. V., Beiser, A., Ibrahim, M., Wilk, A. M., McClellan, S., Klyuyeva, A. V., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02949-7 · Cited by 36 · see citing works

Role of the General Base Glu-268 in Nitroglycerin Bioactivation and Superoxide Formation by Aldehyde Dehydrogenase-2

Wenzl, M. V., Beretta, M., Gorren, A. C. F., Zeller, A., Baral, P. K., Gruber, K. F., Russwurm, M., Koesling, D., Schmidt, K., & Mayer, B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.005652 · Cited by 35 · see citing works

Enhancing Mycoprotein Yield: Metabolic Modulation of Chitin Synthase in Fusarium venenatum

Hong, R., Tong, S., Chai, M., Chen, W., Liu, X., Chen, Y., & Li, D. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c07105 · Cited by 34 · see citing works

Population Distribution of Aldehyde Dehydrogenase-2 Genetic Polymorphism: Implications for Risk Assessment

Ginsberg, G., Smolenski, S., Hattis, D. B., & Sonawane, B. R. (2002) · Regulatory Toxicology and Pharmacology · doi:10.1006/rtph.2002.1591 · Cited by 32 · see citing works

Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice

Choi, S., Neequaye, P., French, S. W., Gonzalez, F. J., & Gyamfi, M. A. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.815217 · Cited by 31 · see citing works

Eliciting the Low-Activity Aldehyde Dehydrogenase Asian Phenotype by an Antisense Mechanism Results in an Aversion to Ethanol

Garver, E. M., Tu, G., Cao, Q.-N., Aini, M., Zhou, F., & Israel, Y. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.5.571 · Cited by 31 · see citing works

Apoferritin as a Carrier of Cu(II) Diethyldithiocarbamate and Biomedical Application for Glutathione-Responsive Combination Chemotherapy

Li, X., Du, K., Sun, J., & Feng, F. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b01014 · Cited by 30 · see citing works

Human Aldehyde Dehydrogenases: A Superfamily of Similar Yet Different Proteins Highly Related to Cancer

Xanthis, V., Mantso, T., Dimtsi, A., Pappa, A., & Fadouloglou, V. E. (2023) · Cancers · doi:10.3390/cancers15174419 · Cited by 33 · see citing works

E-cigarette aerosol exacerbates cardiovascular oxidative stress in mice with an inactive aldehyde dehydrogenase 2 enzyme

Yu, X., Zeng, X., Xiao, F., Chen, R., Sinharoy, P., & Gross, E. R. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102369 · Cited by 29 · see citing works

Protective effect of Aplysin on hepatic injury in ethanol-treated rats

Ge, N., Liang, H., Liu, Y., Ma, A., & Han, L. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.08.071 · Cited by 28 · see citing works

Inhibition of Recombinant Human Mitochondrial Aldehyde Dehydrogenase by Two Intermediate Metabolites of Disulfiram

Mays, D. C., Ortiz‐Bermúdez, P., Lam, J. P., Tong, I. H., Fauq, A. H., & Lipsky, J. J. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00686-2 · Cited by 27 · see citing works

First purification of the antiquitin protein and demonstration of its enzymatic activity

Tang, W., Cheng, C. H. K., & Fong, W. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02553-x · Cited by 27 · see citing works

De novo sequencing of proteolytic peptides by a combination of C-terminal derivatization and nano-electrospray/ collision-induced dissociation mass spectrometry

Lindh, I., Hjelmqvist, L., Bergman, T., Sjövall, J., & Griffiths, W. J. (2000) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(00)00138-0 · Cited by 27 · see citing works

Impact of common ALDH2 inactivating mutation and alcohol consumption on Alzheimer’s disease

Seike, T., Chen, C., & Mochly‐Rosen, D. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1223977 · Cited by 25 · see citing works

Drug interaction between ethanol and 3,4-methylenedioxymethamphetamine (“ecstasy”)

Upreti, V. V., Eddington, N. D., Moon, K., Song, B., & Lee, I. J. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.03.023 · Cited by 25 · see citing works

Structural Insight into the Substrate Gating Mechanism by Staphylococcus aureus Aldehyde Dehydrogenase

Tao, X., Zhang, Z., Zhang, X., Li, H., Sun, H., Mao, Z., & Xia, W. T. (2020) · CCS Chemistry · doi:10.31635/ccschem.020.202000219 · Cited by 24 · see citing works

Fundamental Properties of Aldehyde Dehydrogenase 2 (ALDH2) and the Importance of the ALDH2 Polymorphism

Matsumoto, A. (2016) · Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) · doi:10.1265/jjh.71.55 · Cited by 24 · see citing works

Mutations in mitochondrial aldehyde dehydrogenase (ALDH2) change cofactor affinity and segregate with voluntary alcohol consumption in rats

Sapag, A., Tampier, L., Valle-Prieto, A., Quintanilla, M. E., Moncada, C., & Israel, Y. (2003) · Pharmacogenetics · doi:10.1097/00008571-200308000-00009 · Cited by 24 · see citing works

4-Hydroxynonenal from Mitochondrial and Dietary Sources Causes Lysosomal Cell Death for Lifestyle-Related Diseases

Yamashima, T. (2024) · Nutrients · doi:10.3390/nu16234171 · Cited by 23 · see citing works

Ethanol-metabolizing activities and isozyme protein contents of alcohol and aldehyde dehydrogenases in human liver

Chiang, C., Lai, C., Lee, S., Hsu, W.-L., Chi, Y.-C., Gao, H., Yao, C., Chau, G., & Yin, S. (2016) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000205 · Cited by 23 · see citing works

13C magnetic resonance spectroscopic imaging of hyperpolarized [1‐13C, U‐2H5] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo

Dzien, P., Kettunen, M. I., Marco‐Rius, I., Serrão, E. M., Rodrigues, T. B., Larkin, T. J., Timm, K. N., & Brindle, K. M. (2014) · Magnetic Resonance in Medicine · doi:10.1002/mrm.25286 · Cited by 23 · see citing works

Comparative Study of the Hepatoprotective Efficacy of Artemisia iwayomogi and Artemisia capillaris on Ethanol‐Administered Mice

Lee, H., Seo, K., Yun, K. W., Kim, M., & Lee, M. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2011.02385.x · Cited by 23 · see citing works

Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2

Jackson, B. C., Holmes, R. S., Backos, D. S., Reigan, P., Thompson, D. C., & Vasiliou, V. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.11.022 · Cited by 25 · see citing works

Aromatic aldehydes as fluorogenic indicators for human aldehyde dehydrogenases and oxidases: substrate and isozyme specificity

Wroczyński, P., & Wierzchowski, J. (2000) · The Analyst · doi:10.1039/a906962c · Cited by 23 · see citing works

Rat Liver Constitutive and Phenobarbital-Inducible Cytosolic Aldehyde Dehydrogenases Are Highly Homologous Proteins That Function as Distinct Isozymes

Kathmann, E. C., Naylor, S., & Lipsky, J. J. (2000) · Biochemistry · doi:10.1021/bi001120m · Cited by 23 · see citing works

Activation of mitochondrial aldehyde dehydrogenase (ALDH2) by ALDA-1 reduces both the acquisition and maintenance of ethanol intake in rats: A dual mechanism?

Rivera‐Meza, M., Vásquez, D., Quintanilla, M. E., Lagos, D., Rojas, B., Herrera‐Marschitz, M., & Israel, Y. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.12.001 · Cited by 22 · see citing works

Substrate specificity of human and yeast aldehyde dehydrogenases

Wang, M.-F., Han, C., & Yin, S. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.10.002 · Cited by 86 · see citing works

Hepatic aldehyde dehydrogenase isoenzymes: Differences with respect to species

Tsutsumi, M., Takada, A., Takase, S., & Sugata, K. (1988) · Alcohol · doi:10.1016/0741-8329(88)90040-7 · Cited by 23 · see citing works

Human Aldehyde Dehydrogenase: Kinetic Identification of the Isozyme for Which Biogenic Aldehydes and Acetaldehyde Compete

MacKerell, A. D., Blatter, E. E., & Pietruszko, R. (1986) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1986.tb05087.x · Cited by 44 · see citing works

Human Stomach Aldehyde Dehydrogenase, ALDH3

Hsu, L. C., & Yoshida, A. (1993) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2904-0_16 · Cited by 2 · see citing works

Subcellular distribution of aldehyde dehydrogenase activities in human liver

HENEHAN, G. T. M., Ward, K., Kennedy, N. P., Weir, D. G., & Tipton, K. F. (1985) · Alcohol · doi:10.1016/0741-8329(85)90025-4 · Cited by 31 · see citing works