Increased nitroxidative stress promotes mitochondrial dysfunction in alcoholic and nonalcoholic fatty liver disease
Open accessAbstract
Increased nitroxidative stress causes mitochondrial dysfunctions through oxidative modifications of mitochondrial DNA, lipids, and proteins. Persistent mitochondrial dysfunction sensitizes the target cells/organs to other pathological risk factors and thus ultimately contributes to the development of more severe disease states in alcoholic and nonalcoholic fatty liver disease. The incidences of nonalcoholic fatty liver disease continuously increase due to high prevalence of metabolic syndrome including hyperlipidemia, hypercholesterolemia, obesity, insulin resistance, and diabetes. Many mitochondrial proteins including the enzymes involved in fat oxidation and energy supply could be oxidatively modified (including S-nitrosylation/nitration) under increased nitroxidative stress and thus inactivated, leading to increased fat accumulation and ATP depletion. To demonstrate the underlying mechanism(s) of mitochondrial dysfunction, we employed a redox proteomics approach using biotin-N-maleimide (biotin-NM) as a sensitive biotin-switch probe to identify oxidized Cys residues of mitochondrial proteins in the experimental models of alcoholic and acute liver disease. The aims of this paper are to briefly describe the mechanisms, functional consequences, and detection methods of mitochondrial dysfunction. We also describe advantages and limitations of the Cys-targeted redox proteomics method with alternative approaches. Finally, we discuss various applications of this method in studying oxidatively modified mitochondrial proteins in extrahepatic tissues or different subcellular organelles and translational research.
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Chronic and/or binge alcohol, high fat diets, tobacco smoking, or certain hepatotoxic drugs can directly damage the mitochondrial ETC, producing greater amounts of ROS leaked from the ETS.
“However, chronic and/or binge alcohol, high fat diets, tobacco smoking, or certain hepatotoxic drugs can directly damage the mitochondrial ETC, producing greater amounts of ROS leaked from the ETS [24], [25], [26], [27].”
The actual number of oxidized proteins could be significantly higher than originally reported because of technical limitations in identification, purification and detection, especially for low-abundance proteins.
“However, we believe that the actual number of oxidized proteins could be significantly higher than the proteins originally reported [34], [38], [39], because of the technical limitations in the identification and purification of oxidized proteins and detection methods, especially for those proteins expressed in low abundance, as previously discussed [26], [33].”
Cys residues in adducts with reactive metabolites or lipid peroxides cannot be restored even in the presence of a strong reducing agent DTT and are considered irreversible.
“However, Cys residues in the adducts with reactive metabolites or lipid peroxides cannot be restored even in the presence of a strong reducing agent DTT and thus are considered irreversible, as discussed [26], [33].”
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Cites
Colowick, S. P., Joshi, M. D., Jagannathan, & KAPLAN, N. O. (1966) · Cited by 26,137 · see citing works
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
Esterbauer, H., Schaur, R. J., & Zollner, H. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90192-6 · Cited by 6,672 · see citing works
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455 · see citing works
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390 · see citing works
Large-scale analysis of the yeast proteome by multidimensional protein identification technology
Washburn, M. P., Wolters, D. A., & Yates, J. R. (2001) · Nature Biotechnology · doi:10.1038/85686 · Cited by 4,759 · see citing works
Correlation between Protein and mRNA Abundance in Yeast
Gygi, S. P., Rochon, Y., Franza, B. R., & Aebersold, R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.1720 · Cited by 3,819 · see citing works
Protein Oxidation in Aging, Disease, and Oxidative Stress
Berlett, B. S., & Stadtman, E. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20313 · Cited by 3,339 · see citing works
Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185 · see citing works
Boveris, A., & Chance, B. (1973) · Biochemical Journal · doi:10.1042/bj1340707 · Cited by 2,626 · see citing works
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,499 · see citing works
Molecular mechanisms of necroptosis: an ordered cellular explosion
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382 · see citing works
Difference gel electrophoresis. A single gel method for detecting changes in protein extracts
Ünlü, M., Morgan, M. E., & Minden, J. S. (1997) · Electrophoresis · doi:10.1002/elps.1150181133 · Cited by 2,180 · see citing works
Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
Gao, B., & Bataller, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.09.002 · Cited by 1,963 · see citing works
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Hirschey, M. D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D. B., Grueter, C. A., Harris, C., Biddinger, S., Ilkayeva, O. R., et al. (2010) · Nature · doi:10.1038/nature08778 · Cited by 1,687 · see citing works
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
Ahn, B.-H., Kim, H.-S., Song, S., Lee, I. H., Liu, J., Vassilopoulos, A., Deng, C.-X., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803790105 · Cited by 1,291 · see citing works
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
Hamanaka, R. B., & Chandel, N. S. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.002 · Cited by 1,011 · see citing works
Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
Marchitti, S. A., Brocker, C. N., Stagos, D., & Vasiliou, V. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.6.697 · Cited by 806 · see citing works
The Biotin Switch Method for the Detection of S -Nitrosylated Proteins
Jaffrey, S. R., & Snyder, S. H. (2001) · Science s STKE · doi:10.1126/stke.2001.86.pl1 · Cited by 805 · see citing works
Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart
Chen, C., Budas, G. R., Churchill, E. N., Disatnik, M., Hurley, T. D., & Mochly‐Rosen, D. (2008) · Science · doi:10.1126/science.1158554 · Cited by 766 · see citing works
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
Leclercq, I. A., Farrell, G. C., Field, J., Bell, D., Gonzalez, F. J., & Robertson, G. R. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8814 · Cited by 763 · see citing works
Mitochondrial dysfunction in Nash: causes, consequences and possible means to prevent it
Begriche, K., Igoudjil, A., Pessayre, D., & Fromenty, B. (2006) · Mitochondrion · doi:10.1016/j.mito.2005.10.004 · Cited by 753 · see citing works
Catalá, A. (2009) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2008.09.004 · Cited by 745 · see citing works
Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis
Lieber, C. S. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.07.008 · Cited by 699 · see citing works
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
Fromenty, B., & Pessayre, D. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)00012-6 · Cited by 665 · see citing works
Wu, W. W., Wang, G., Baek, S. J., & Shen, R. (2006) · Journal of Proteome Research · doi:10.1021/pr050405o · Cited by 576 · see citing works
Alcohol and mitochondria: a dysfunctional relationship
Hoek, J. B., Cahill, A., & Pastorino, J. G. (2002) · Gastroenterology · doi:10.1053/gast.2002.33613 · Cited by 553 · see citing works
Oxidative Stress, Toxicology, and Pharmacology of CYP2E1
Caro, A. A., & Cederbaum, A. I. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121704 · Cited by 513 · see citing works
Alcohollike liver disease in nonalcoholics
Diehl, A. M., Goodman, Z. D., & Ishak, K. G. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90183-7 · Cited by 484 · see citing works
Brooks, P. J., Enoch, M.-A., Goldman, D., Li, T.-K., & Yokoyama, A. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000050 · Cited by 480 · see citing works
Kim, B.-J., Ryu, S.-W., & Song, B.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510644200 · Cited by 470 · see citing works
Self-citationEffects of peroxynitrite‐induced protein modifications on tyrosine phosphorylation and degradation
Gow, A. J., Duran, D., Malcolm, S., & Ischiropoulos, H. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00347-x · Cited by 449 · see citing works
Dalle‐Donne, I., Scaloni, A., Giustarini, D., Cavarra, E., Tell, G., Lungarella, G., Colombo, R., Rossi, R., & Milzani, A. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20006 · Cited by 448 · see citing works
Wells, P. G., McCallum, G. P., Chen, C. S., Henderson, J. T., Lee, C. J. J., Perstin, J., Preston, T. J., Wiley, M. J., & Wong, A. W. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfn263 · Cited by 430 · see citing works
The Neuropathology of Alcohol-Related Brain Damage
Harper, C. (2009) · Alcohol and Alcoholism · doi:10.1093/alcalc/agn102 · Cited by 420 · see citing works
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
Kendrick, A. A., Choudhury, M., Rahman, S. M., McCurdy, C. E., Friederich, M., Van Hove, J. L. K., Watson, P. A., Birdsey, N., Bao, J., Gius, D., et al. (2011) · Biochemical Journal · doi:10.1042/bj20100791 · Cited by 382 · see citing works
Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics
Yokoyama, A. (1998) · Carcinogenesis · doi:10.1093/carcin/19.8.1383 · Cited by 368 · see citing works
Molecular Mechanisms of Alcoholic Fatty Liver
Purohit, V., Gao, B., & Song, B. (2009) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00827.x · Cited by 312 · see citing works
Self-citationMitochondrial shape changes: orchestrating cell pathophysiology
Campello, S., & Scorrano, L. (2010) · EMBO Reports · doi:10.1038/embor.2010.115 · Cited by 296 · see citing works
Fischer, M., You, M., Matsumoto, M., & Crabb, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302140200 · Cited by 291 · see citing works
Kim, J.-R., Yoon, H. W., Kwon, K., Lee, S.-R., & Rhee, S. G. (2000) · Analytical Biochemistry · doi:10.1006/abio.2000.4623 · Cited by 273 · see citing works
Fromenty, B., & Pessayre, D. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80496-5 · Cited by 268 · see citing works
The chemical biology of S-nitrosothiols
Broniowska, K. A., & Hogg, N. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4590 · Cited by 259 · see citing works
Hu, Y., Suárez, J., Fricovsky, E. S., Wang, H., Scott, B. T., Trauger, S. A., Han, W., Hu, Y., Oyeleye, M. O., & DILLMANN, W. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808518200 · Cited by 253 · see citing works
Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver
Kasdallah-Grissa, A., Mornagui, B., Aouani, E., et al. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.11.044 · Cited by 250 · see citing works
PPARα Expression Protects Male Mice from High Fat–Induced Nonalcoholic Fatty Liver1–3
Abdelmegeed, M. A., Yoo, S.-H., Henderson, L. E., Gonzalez, F. J., Woodcroft, K. J., & Song, B. (2011) · Journal of Nutrition · doi:10.3945/jn.110.135210 · Cited by 250 · see citing works
Self-citationMcKim, S. E., Gäbele, E., Isayama, F., Lambert, J. C., Tucker, L. M., Wheeler, M. D., Connor, H. D., Mason, R. P., Doll, M. A., Hein, D. W., et al. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.08.030 · Cited by 243 · see citing works
Hartley, D. P., Ruth, J. A., & Petersen, D. R. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1028 · Cited by 243 · see citing works
Abdelmegeed, M. A., Banerjee, A., Yoo, S.-H., Jang, S., Gonzalez, F. J., & Song, B. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.05.019 · Cited by 241 · see citing works
Self-citationOxidative stress and antioxidants in hepatic pathogenesis
Ha, H. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i48.6035 · Cited by 236 · see citing works
Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III
Bailey, S. M., Pietsch, E. C., & CUNNINGHAM, C. C. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00138-0 · Cited by 224 · see citing works
Nitric oxide and nitroxidative stress in Alzheimer's disease
Malinski, T. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-11208 · Cited by 220 · see citing works
Lancaster, J. R. (2006) · Chemical Research in Toxicology · doi:10.1021/tx060061w · Cited by 219 · see citing works
Effects of chronic ethanol treatment on mitochondrial functions damage to coupling site I
Cederbaum, A. I., Lieber, C. S., & Rubin, E. (1974) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(74)90283-5 · Cited by 217 · see citing works
Mitochondrial Glutathione: Importance and Transport
Fernández-Checa, J. C., Kaplowitz, N., García‐Ruiz, C., & Colell, A. (1998) · Seminars in Liver Disease · doi:10.1055/s-2007-1007172 · Cited by 211 · see citing works
An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice
Mansouri, A., Gaou, I., de Kerguenec, C., Amsellem, S., Haouzi, D., Berson, A., Moreau, A., Feldmann, G., Lettéron, P., Pessayre, D., et al. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70566-4 · Cited by 208 · see citing works
Oxidative stress and Alzheimer’s disease: dietary polyphenols as potential therapeutic agents
Darvesh, A. S., Carroll, R. T., Bishayee, A., Geldenhuys, W. J., & der Schyf, C. J. V. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.42 · Cited by 203 · see citing works
Inhibition by nitric oxide of the repair protein, O6-DNA-methyltransferase
Laval, F., & Wink, D. A. (1994) · Carcinogenesis · doi:10.1093/carcin/15.3.443 · Cited by 201 · see citing works
Klyosov, A. A., Rashkovetsky, L. G., Tahir, M. K., & Keung, W.-M. (1996) · Biochemistry · doi:10.1021/bi9521093 · Cited by 200 · see citing works
Brocker, C. N., Lassen, N., Estey, T., Pappa, A., Cantore, M., Orlova, V. V., Chavakis, T., Kavanagh, K. L., Oppermann, U. C. T., & Vasiliou, V. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.077925 · Cited by 200 · see citing works
Chen, C., Krausz, K. W., Shah, Y. M., Idle, J. R., & Gonzalez, F. J. (2009) · Chemical Research in Toxicology · doi:10.1021/tx800464q · Cited by 181 · see citing works
Lu, H., Koshkin, V., Allister, E. M., Gyulkhandanyan, A. V., & Wheeler, M. B. (2009) · Diabetes · doi:10.2337/db09-0129 · Cited by 178 · see citing works
Minko, I. G., Kozekov, I. D., Harris, T. M., Rizzo, C. J., Lloyd, R. S., & Stone, M. P. (2009) · Chemical Research in Toxicology · doi:10.1021/tx9000489 · Cited by 176 · see citing works
Venkatraman, A., Landar, A., Davis, A. J., Chamlee, L., Sanderson, T., Kim, H., Page, G., Pompilius, M., Ballinger, S., Darley-Usmar, V., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402245200 · Cited by 170 · see citing works
Yang, Y., Çimen, H., Han, M.-J., Shi, T., Deng, J., Koç, H., Palacios, O. M., Montier, L., Bai, Y., Tong, Q., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053421 · Cited by 164 · see citing works
Day, C. P., Bashir, R., James, O., Bassendine, M. F., Crabb, D. W., Thomasson, H. R., Li, T., & Edenberg, H. J. (1991) · Hepatology · doi:10.1002/hep.1840140509 · Cited by 155 · see citing works
Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease
McCullough, R. L., Galligan, J. J., Stewart, B. J., & Petersen, D. R. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.02.021 · Cited by 154 · see citing works
Genetic insights into OXPHOS defect and its role in cancer
Chandra, D., & Singh, K. K. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.10.023 · Cited by 150 · see citing works
Hardwick, J. P., Osei‐Hyiaman, D., Wiland, H. O., Abdelmegeed, M. A., & Song, B. (2009) · PPAR Research · doi:10.1155/2009/952734 · Cited by 148 · see citing works
Self-citationCalcerrada, P., Peluffo, G., & Radí, R. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798357719 · Cited by 141 · see citing works
Inhibition of Human Mitochondrial Aldehyde Dehydrogenase by 4-Hydroxynon-2-enal and 4-Oxonon-2-enal
Doorn, J. A., Hurley, T. D., & Petersen, D. R. (2006) · Chemical Research in Toxicology · doi:10.1021/tx0501839 · Cited by 140 · cited 15× · see citing works
“ALDH2: Mitochondrial low-Km aldehyde dehydrogenase 2 BIAM: Biotin-conjugated iodoacetamide Biotin-NM: Biotin-N-maleimide Complex I: NADH-dependent ubiquinone oxidoreductase Complex III: Cytochrome c reductase Complex IV: Cytochrome c oxidase CYP2E1: Ethanol-inducible cytochrome P450 2E1 isozyme DIGE: Difference in gel…”
BackgroundInfluentialMultiple hepatic mitochondrial DNA deletions suggest premature oxidative aging in alcoholic patients
Mansouri, A., Fromenty, B., Berson, A., Robin, M., Grimbert, S., Beaugrand, M., Erlinger, S., & Pessayre, D. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80286-3 · Cited by 136 · see citing works
Otani, K., Korenaga, M., Beard, M. R., Li, K., Qian, T., Showalter, L., Singh, A. K., Wang, T., & Weinman, S. A. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.10.045 · Cited by 134 · see citing works
4-hydroxynonenal inhibits SIRT3 via thiol-specific modification
Fritz, K. S., Galligan, J. J., Smathers, R. L., Roede, J. R., Shearn, C. T., Reigan, P., & Petersen, D. R. (2011) · Chemical Research in Toxicology · doi:10.1021/tx100355a · Cited by 127 · see citing works
Protein and lipid nitration: Role in redox signaling and injury
Rubbo, H., & Radí, R. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.03.007 · Cited by 126 · see citing works
Muto, M., Hitomi, Y., Ohtsu, A., Ebihara, S., Yoshida, S., & Esumi, H. (2000) · Gut · doi:10.1136/gut.47.2.256 · Cited by 121 · see citing works
Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats
Moon, K.-H., Hood, B. L., Kim, B.-J., Hardwick, J. P., Conrads, T. P., Veenstra, T. D., & Song, B. J. (2006) · Hepatology · doi:10.1002/hep.21372 · Cited by 120 · see citing works
Self-citationBansal, S., Liu, C., Sepuri, N. B. V., Anandatheerthavarada, H. K., Selvaraj, V., Hoek, J. B., Milne, G. L., Guengerich, F. P., & Avadhani, N. G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.121822 · Cited by 118 · see citing works
Isotope-coded Affinity Tag Approach to Identify and Quantify Oxidant-sensitive Protein Thiols
Sethuraman, M., McComb, M. E., Heibeck, T. H., et al. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.t300011-mcp200 · Cited by 117 · see citing works
The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in mice
Venkatraman, A., Shiva, S., Wigley, A., Ulasova, E., Chhieng, D., Bailey, S. M., & Darley-Usmar, V. M. (2004) · Hepatology · doi:10.1002/hep.20326 · Cited by 117 · see citing works
Song, B., Moon, K., Olsson, N., & Salem, N. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.04.023 · Cited by 115 · see citing works
Self-citationDavidsson, P., Paulson, L., Hesse, C., Blennow, K., & Nilsson, C. L. (2001) · PROTEOMICS · doi:10.1002/1615-9861(200103)1:3 · Cited by 111 · see citing works
Evidence for the Existence in Arabidopsis thaliana of the Proteasome Proteolytic Pathway
Polge, C., Jaquinod, M., Holzer, F. M., Bourguignon, J., Walling, L. L., & Brouquisse, R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.035394 · Cited by 110 · see citing works
S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver
Bailey, S. M., Robinson, G., Pinner, A. L., Chamlee, L., Ulasova, E., Pompilius, M., Page, G. P., Chhieng, D., Jhala, N. C., Landar, A. L., et al. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00044.2006 · Cited by 110 · see citing works
Neuroprotection by Minocycline Caused by Direct and Specific Scavenging of Peroxynitrite
Schildknecht, S., Pape, R., Müller, N., Robotta, M., Marquardt, A., Bürkle, A., Drescher, M., & Leist, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.169565 · Cited by 107 · see citing works
An ascorbate-dependent artifact that interferes with the interpretation of the biotin switch assay
Huang, B., & Chen, C. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.03.006 · Cited by 106 · see citing works
Proteomic approaches to the characterization of protein thiol modification
Chouchani, E. T., James, A. M., Fearnley, I. M., Lilley, K. S., & Murphy, M. P. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.11.003 · Cited by 106 · see citing works
Moon, K., Hood, B. L., Mukhopadhyay, P., Rajesh, M., Abdelmegeed, M. A., Kwon, Y., Conrads, T. P., Veenstra, T. D., Song, B., & Pacher, P. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.048 · Cited by 103 · see citing works
Self-citationUnbiased identification of cysteine S-nitrosylation sites on proteins
Derakhshan, B., Wille, P. C., & Gross, S. S. (2007) · Nature Protocols · doi:10.1038/nprot.2007.210 · Cited by 94 · see citing works
Mitochondrial off targets of drug therapy
Wallace, K. B. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.04.001 · Cited by 90 · see citing works
Okiyama, W., Tanaka, N., Nakajima, T., Tanaka, E., Kiyosawa, K., Gonzalez, F. J., & Aoyama, T. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.01.025 · Cited by 90 · see citing works
Park, K., Cho, S. Y., Kim, H., & Paik, Y. (2001) · International Journal of Cancer · doi:10.1002/ijc.1585 · Cited by 86 · see citing works
Oxidative modification of hepatic mitochondria protein thiols: effect of chronic alcohol consumption
Venkatraman, A., Landar, A., Davis, A. J., Ulasova, E., Page, G., Murphy, M. P., Darley-Usmar, V., & Bailey, S. M. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00399.2003 · Cited by 85 · see citing works
Role of alcohol metabolism in chronic pancreatitis.
Vonlaufen, A., Wilson, J. S., Pirola, R. C., & Apte, M. V. (2007) · Europe PMC (PubMed Central) · Cited by 84 · see citing works
Chen, J., Petersen, D. R., Schenker, S., & Henderson, G. I. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200004000-00030 · Cited by 84 · see citing works
Sudheer, A. R., Muthukumaran, S., Nagarajan, D., Devaraj, H., & Menon, V. P. (2007) · Toxicology · doi:10.1016/j.tox.2007.10.016 · Cited by 83 · see citing works
Kim, B., Hood, B. L., Aragon, R. A., Hardwick, J. P., Conrads, T. P., Veenstra, T. D., & Song, B. J. (2006) · PROTEOMICS · doi:10.1002/pmic.200500447 · Cited by 83 · see citing works
Self-citationIdentification of a 54-kDa Mitochondrial Acetaminophen-Binding Protein as Aldehyde Dehydrogenase
Landin, J. S., Cohen, S. D., & Khairallah, E. A. (1996) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(96)80036-6 · Cited by 82 · see citing works
Abdelmegeed, M. A., Moon, K.-H., Chen, C., Gonzalez, F. J., & Song, B.-J. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.07.016 · Cited by 81 · see citing works
Self-citationRoles of alcohol and tobacco exposure in the development of hepatocellular carcinoma
Purohit, V., Rapaka, R. S., Kwon, O. S., & Song, B. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.10.009 · Cited by 76 · see citing works
Self-citationSuh, S., Hood, B. L., Kim, B., Conrads, T. P., Veenstra, T. D., & Song, B. J. (2004) · PROTEOMICS · doi:10.1002/pmic.200400971 · Cited by 76 · see citing works
Self-citationMitochondrial dysfunction in human pathologies
Monsalve, M. (2006) · Frontiers in bioscience · doi:10.2741/2132 · Cited by 75 · see citing works
Intramitochondrial crystalline inclusions in nonalcoholic steatohepatitis†
Caldwell, S. H., de Freitas, L. A. R., Park, S. H., Moreno, M. L. V., Redick, J. A., Davis, C. A., Sisson, B. J., Patrie, J. T., Cotrim, H. P., Argo, C. K., et al. (2009) · Hepatology · doi:10.1002/hep.22851 · Cited by 75 · see citing works
Robin, M., Demeilliers, C., Sutton, A., Paradis, V., Maisonneuve, C., Dubois, S., Poirel, O., Lettéron, P., Pessayre, D., & Fromenty, B. (2005) · Hepatology · doi:10.1002/hep.20949 · Cited by 75 · see citing works
Endocannabinoids and liver disease† ‡
Jiménez, W. (2005) · Hepatology · doi:10.1002/hep.20714 · Cited by 74 · see citing works
Role of peroxisome proliferator-activated receptor-α in fasting-mediated oxidative stress
Abdelmegeed, M. A., Moon, K.-H., Hardwick, J. P., Gonzalez, F. J., & Song, B.-J. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.06.017 · Cited by 74 · see citing works
Self-citationBlack, W. J., Stagos, D., Marchitti, S. A., Nebert, D. W., Tipton, K. F., Bairoch, A., & Vasiliou, V. (2009) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3283329023 · Cited by 74 · see citing works
Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications
Song, B.-J., Abdelmegeed, M. A., Yoo, S.-H., Kim, B.-J., Jo, S. A., Jo, I., & Moon, K.-H. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.05.013 · Cited by 73 · see citing works
Mechanisms of MDMA (Ecstasy)-Induced Oxidative Stress, Mitochondrial Dysfunction, and Organ Damage
Song, B., Moon, K., Upreti, V. V., Eddington, N. D., & Lee, I. J. (2010) · Current Pharmaceutical Biotechnology · doi:10.2174/138920110791591436 · Cited by 73 · see citing works
Self-citationInhibition of mitochondrial aldehyde dehydrogenase by nitric oxide‐mediated S‐nitrosylation
Moon, K., Kim, B., & Song, B. J. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.09.082 · Cited by 73 · see citing works
Self-citationAscorbic Acid and Reducing Agents Regulate the Fates and Functions of S-Nitrosothiols
Kashiba-Iwatsuki, M., Kitoh, K., Kasahara, E., Yu, H., Nisikawa, M., MATSUO, M., & Inoue, M. (1997) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021883 · Cited by 70 · see citing works
Redox Signaling and the Innate Immune System in Alcoholic Liver Disease
Cohen, J. I., Chen, X., & Nagy, L. E. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3746 · Cited by 69 · see citing works
Alcohol and the heart: biochemical alterations
Preedy, V. R., Patel, V. B., Why, H., Corbett, J. M., Dunn, M. J., & Richardson, P. (1996) · Cardiovascular Research · doi:10.1016/s0008-6363(95)00184-0 · Cited by 67 · see citing works
Effects of Carvedilol and Its Analog BM-910228 on Mitochondrial Function and Oxidative Stress
Abreu, R. M. V., Santos, D. L., & Moreno, A. J. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39002-0 · Cited by 67 · see citing works
Moderate Alcohol Consumption Aggravates High‐Fat Diet Induced Steatohepatitis in Rats
Wang, Y., Seitz, H. K., & Wang, X. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01122.x · Cited by 65 · see citing works
Overview — In vitro inhibition of aldehyde dehydrogenase by disulfiram and metabolites
Lipsky, J. J., Shen, M. L., & Naylor, S. (2001) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(00)00224-6 · Cited by 65 · see citing works
Sampey, B. P., Korourian, S., Ronis, M. J. J., Badger, T. M., & Petersen, D. R. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2003.tb04430.x · Cited by 64 · see citing works
Moon, K., Upreti, V. V., Yu, L., Lee, I. J., Ye, X., Eddington, N. D., Veenstra, T. D., & Song, B. (2008) · PROTEOMICS · doi:10.1002/pmic.200800215 · Cited by 62 · see citing works
Self-citationEndocannabinoids and Liver Disease. IV. Endocannabinoid involvement in obesity and hepatic steatosis
Kunos, G., & Osei‐Hyiaman, D. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00057.2008 · Cited by 61 · see citing works
Mechanisms Underlying the Hepatotoxic Effects of Ecstasy
Carvalho, M. C., Pontes, H., Remião, F., Bastos, M. D. L., & Carvalho, F. D. (2010) · Current Pharmaceutical Biotechnology · doi:10.2174/138920110791591535 · Cited by 61 · see citing works
Proteome Screens for Cys Residues Oxidation
Chiappetta, G., Ndiaye, S., Igbaria, A., Kumar, C., Vinh, J., & Tolédano, M. B. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)73010-x · Cited by 60 · see citing works
Chen, J., Robinson, N. C., Schenker, S., Frosto, T. A., & Henderson, G. I. (1999) · Hepatology · doi:10.1002/hep.510290611 · Cited by 60 · see citing works
Regulation of energy metabolism in liver
Soboll, S. (1995) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf02111655 · Cited by 54 · see citing works
Narasimhulu, S. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250903329095 · Cited by 53 · see citing works
Endotoxin causes functional endoplasmic reticulum failure, possibly mediated by mitochondria
Kozlov, A. V., Duvigneau, J. C., Miller, I., Nürnberger, S., Gesslbauer, B., Kungl, A. J., Öhlinger, W., Hartl, R. T., Gille, L., Staniek, K., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.03.004 · Cited by 53 · see citing works
Inhibition of rat liver aldehyde dehydrogenases by acrolein.
Mitchell, D., & Petersen, D. R. (1988) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)06899-0 · Cited by 52 · see citing works
Andringa, K. K., Bajt, M. L., Jaeschke, H., & Bailey, S. M. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.01.010 · Cited by 51 · see citing works
Cerretani, D., Riezzo, I., Fiaschi, A. I., et al. (2008) · International Journal of Legal Medicine · doi:10.1007/s00414-008-0262-2 · Cited by 51 · see citing works
Pawlosky, R. J., Flynn, B. M., & Salem, N. (1997) · Hepatology · doi:10.1002/hep.510260602 · Cited by 50 · see citing works
Menzies, K. J., Robinson, B. H., & Hood, D. A. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00415.2007 · Cited by 49 · see citing works
MDMA Toxicity and Pathological Consequences: A Review About Experimental Data and Autopsy Findings
Turillazzi, E., Riezzo, I., Neri, M., et al. (2010) · Current Pharmaceutical Biotechnology · doi:10.2174/138920110791591481 · Cited by 42 · see citing works
Widmer, R., Kaiser, B., Engels, M., Jung, T., & Grune, T. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.03.027 · Cited by 41 · see citing works
In-Gel Detection of S-Nitrosated Proteins Using Fluorescence Methods
Kettenhofen, N. J., Wang, X., Gladwin, M. T., & Hogg, N. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)01204-4 · Cited by 39 · see citing works
Inactivation of cytosolic aldehyde dehydrogenase viaS‐nitrosylation in ethanol‐exposed rat liver
Moon, K., Abdelmegeed, M. A., & Song, B. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.07.037 · Cited by 39 · see citing works
Self-citationMitochondrial oxidation of 4‐hydroxy‐2‐nonenal in rat cerebral cortex
Murphy, T. C., Amarnath, V., & Picklo, M. J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01628.x · Cited by 38 · see citing works
Moon, K.-H., Lee, Y.-M., & Song, B.-J. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.11.008 · Cited by 37 · see citing works
Self-citationGladwin, M. T., Wang, X., & Hogg, N. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.025 · Cited by 35 · see citing works
Effects of Docosahexaenoic Acid in an Experimental Rat Model of Nonalcoholic Steatohepatitis
Takayama, F., Nakamoto, K., Totani, N., Yamanushi, T. T., Kabuto, H., Kaneyuki, T., & Mankura, M. (2010) · Journal of Oleo Science · doi:10.5650/jos.59.407 · Cited by 33 · see citing works
Aldehyde Dehydrogenase in Alcoholic Subjects
Palmer, K. R., & Jenkins, W. J. (1985) · Hepatology · doi:10.1002/hep.1840050218 · Cited by 33 · see citing works
Wan, J., Bae, M.-A., & Song, B.-J. (2004) · Experimental & Molecular Medicine · doi:10.1038/emm.2004.10 · Cited by 32 · see citing works
Self-citationPowell, C. L., Kosyk, O., Bradford, B. U., et al. (2005) · Hepatology · doi:10.1002/hep.20910 · Cited by 32 · see citing works
Donthamsetty, S., Bhave, V., Mitra, M. S., Latendresse, J. R., & Mehendale, H. M. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.02.031 · Cited by 30 · see citing works
Alcoholic Liver Disease: From Pathophysiology to Therapy
Seitz, H. K., Lieber, C. S., Stickel, F., Salaspuro, M. P., SCHLEMMER, H., & Horie, Y. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000171896.37022.f7 · Cited by 29 · see citing works
Drug interaction between ethanol and 3,4-methylenedioxymethamphetamine (“ecstasy”)
Upreti, V. V., Eddington, N. D., Moon, K., Song, B., & Lee, I. J. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.03.023 · Cited by 25 · see citing works
Self-citationBanfi, P., Lanzi, C., Falvella, F. S., Gariboldi, M., Gambetta, R. A., & Dragani, T. A. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09830-x · Cited by 24 · see citing works
Upreti, V. V., Moon, K., Yu, L., Lee, I. J., Eddington, N. D., Ye, X., Veenstra, T. D., & Song, B. (2010) · PROTEOMICS · doi:10.1002/pmic.201000203 · Cited by 20 · see citing works
Self-citationSong, B.-J., Suh, S.-K., & Moon, K.-H. (2010) · Methods in Enzymology · doi:10.1016/s0076-6879(10)73013-5 · Cited by 18 · see citing works
Self-citationMitochondrial Gene Profiling: Translational Perspectives
Johnston, D. S., Su, Y. A., & Alesci, S. (2009) · Pharmacogenomics · doi:10.2217/pgs.09.112 · Cited by 12 · see citing works
Andringa, K. K., & Bailey, S. M. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)74006-4 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
LeFort, K. R., Rungratanawanich, W., & Song, B.-J. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05061-7 · Cited by 202 · see citing works
Self-citationSong, B.-J., Akbar, M., Abdelmegeed, M. A., Byun, K., Lee, B., Yoon, S. K., & Hardwick, J. P. (2014) · Redox Biology · doi:10.1016/j.redox.2014.10.004 · Cited by 123 · see citing works
“As recently reviewed [26,27], Cys residue(s) can be oxidatively modified in many forms [sulfenic acid, disulfide, sulfinic/sulfonic acids, NOor peroxynitrite-dependent S-nitrosylation, NO-independent ADPribosylation, mixed disulfide formation between Cys residues and glutathione (glutathionylation), cysteine (cystathi…”
BackgroundMethodInfluentialSelf-citation
- Authors
- Song, B.-J., Abdelmegeed, M. A., Henderson, L. E., Yoo, S.-H., Wan, J., Purohit, V., Hardwick, J. P., & Moon, K.-H.
- Affiliations
- National Institutes of Health (US)
- National Institute on Drug Abuse (US)
- Northeast Ohio Medical University (US)
- Corresponding author
- Song, Byoung-Joon
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Hindawi Limited
- Published
- 2013
- Volume
- 2013
- Pages
- 1-14
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC3649774
- OpenAlex
- W2112596550
- Cited by
- 67
- References
- 148
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 10 · 2016: 5 · 2015: 9 · 2014: 3 · 2013: 4
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (Z99‐AA999999)
- National Institute on Alcohol Abuse and Alcoholism (ZIAAA000036)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- nitro-oxidative stress, mitochondrial dysfunction, alcoholic fatty liver, non-alcoholic fatty liver disease, S-nitrosylation, redox proteomics, cysteine oxidation, metabolic syndrome, fat oxidation, ATP depletion, acute liver disease
- MeSH terms
- Animals, Fatty Liver, Fatty Liver, Alcoholic, Humans, Mitochondria, Oxidative Stress, Reactive Nitrogen Species, Proteomics, Non-alcoholic Fatty Liver Disease
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