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Melting and Crystallization Behaviors of Biodegradable Polymers Enzymatically Coalesced from Their Cyclodextrin Inclusion Complexes
Abstract
Inclusion complexed (IC) and coalesced biodegradable poly(epsilon-caprolactone) (PCL), poly(L-lactic acid) (PLLA), and their diblock copolymer (PCL-b-PLLA) were achieved by forming ICs between host alpha-cyclodextrin(alpha-CD) and guest PCL, PLLA, and PCL-b-PLLA, followed by removing the alpha-CD host with an amylase enzyme. FTIR spectra of the coalesced polymers reveal that the host alpha-CD can be completely removed, without polymer degradation, by treatment with an amylase enzyme. The melting and crystallization behavior of these CD-IC treated polymers, which are crystallizable, biodegradable, and bioabsorbable, are investigated by differential scanning calorimetry (DSC) and polarized optical microscopy. Results show that coalescence increased the crystallinities of the homopolymers but decreased that of the diblock copolymer. The Avrami exponent (n), derived from both isothermal and nonisothermal crystallization models for homo-PCL and -PLLA and the PCL and PLLA blocks in the diblock copolymer samples coalesced from their ICs, is close to 4, indicating homogeneous crystallization, whereas crystallization of the blocks in the as-synthesized diblock copolymer yields an Avrami exponent around 3, indicating heterogeneous crystallization. All of these results demonstrate that the PCL and PLLA homopolymers and blocks in the IC-coalesced samples are more readily and homogeneously crystallized than those in the as-synthesized samples or their physical blend, even though the level…
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A detailed study of the crystallization kinetics and morphology of both blocks, and their dependence with composition in a wide range, has not been reported.
“Although these systems have been previously evaluated 30 -35 and morphological studies have been previously performed by SAXS, 24,27,28 a detailed study of the crystallization kinetics and morphology of both blocks, and their dependence with composition in a wide range has not been reported, as far as we are aware.”
From Crystallization Kinetics and Morphology of Biodegradable Double Crystalline PLLA- b -PCL Diblock Copolymers (2010) · cites this paper as [31]
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Metadata
- Authors
- Wei, M., Shuai, X., & Tonelli, A. E.
- Affiliations
- North Carolina State University (US)
- Corresponding author
- Tonelli, Alan E.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-04-12
- Volume
- 4
- Issue
- 3
- Pages
- 783-792
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2052301004
- Cited by
- 56
- References
- 29
- Citations by year
- 2024: 2 · 2023: 1 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomacromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer crystallization and properties
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- amylase, polycaprolactone, poly(L-lactic acid), biodegradable polymers, melting behavior, crystallization kinetics, Avrami exponent, crystallinity, homogeneous crystallization, heterogeneous crystallization, host-guest complexation
- MeSH terms
- Biodegradation, Environmental, Crystallization, Cyclodextrins, Polymers
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