The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
How Autocatalysis Accelerates Drug Release from PLGA-Based Microparticles: A Quantitative Treatment
Abstract
The major aim of this study was to better understand the importance of autocatalysis in poly(lactic-co-glycolic acid) (PLGA)-based microparticles used as controlled drug delivery systems. Upon contact with biological fluids, PLGA is degraded into shorter chain alcohols and acids. An accumulation of the latter can lead to significant drops in micro-pH and subsequent accelerated polymer degradation. The system size, determining the diffusion path lengths, plays a crucial role for the occurrence/absence of autocatalytic effects. Using an oil-in-water solvent-extraction/evaporation process, different-sized drug-free and drug-loaded, PLGA-based microparticles were prepared and physicochemically characterized (SEM, DSC, SEC, optical microscopy, and UV-spectrophotometry) before and upon exposure to simulated biological fluids. Based on these experimental results, an adequate mathematical theory was developed describing the dominating mass transfer processes and chemical reactions. Importantly, a quantitative relationship could be established between the dimension of the device and the resulting drug release patterns, taking the effects of autocatalysis into account.
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“According to pseudo-first-order kinetics (Siepmann et al., 2005), the degradation curves of the microspheres were good-fitted, which was reflected by the acceptable regression coefficients”
From Electrosprayed minocycline hydrochloride-loaded microsphere/SAIB hybrid depot for periodontitis treatment (2021) · cites this paper as Siepmann et al., 2005
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Cites
Polymeric systems for controlled drug release
Uhrich, K. E., Cannizzaro, S. M., Langer, R. S., & Shakesheff, K. M. (1999) · Chemical Reviews · doi:10.1021/cr940351u · Cited by 2,633
Raman, C., Berkland, C., Kim, K. (., & Pack, D. W. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.11.012 · Cited by 166
(1998) · Nature · doi:10.1038/32020 · Cited by 76
Cited by
Modeling of diffusion controlled drug delivery
Siepmann, J., & Siepmann, F. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.10.006 · Cited by 935
Self-citationArifin, D. Y., Lee, L. Y., & Wang, C.-H. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.007 · Cited by 674
Poly(lactic-co-glycolic) Acid-Controlled-Release Systems: Experimental and Modeling Insights
Hines, D. J., & Kaplan, D. L. (2013) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.2013006475 · Cited by 396
Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics
Ding, D., & Zhu, Q. (2018) · Materials Science and Engineering: C · doi:10.1016/j.msec.2017.12.036 · Cited by 386
How porosity and size affect the drug release mechanisms from PLGA-based microparticles
Klose, D., Siepmann, F., Elkharraz, K., Krenzlin, S., & Siepmann, J. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.07.031 · Cited by 358
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Metadata
- Authors
- Siepmann, J., Elkharraz, K., Siepmann, F., & Klose, D.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-06-01
- Volume
- 6
- Issue
- 4
- Pages
- 2312-2319
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W1979512544
- Cited by
- 308
- References
- 3
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- closed
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