The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Preparation and Characterization of Nanoparticles Shelled with Chitosan for Oral Insulin Delivery
Abstract
Nanoparticles (NPs) composed of chitosan (CS) and poly(gamma-glutamic acid) (gamma-PGA) were prepared by a simple ionic-gelation method for oral insulin delivery. Fourier transform infrared (FT-IR) spectra indicated that CS and gamma-PGA were ionized at pH 2.5-6.6, while X-ray diffractograms demonstrated that the crystal structure of CS was disrupted after it was combined with gamma-PGA. The diameters of the prepared NPs were in the range of 110-150 nm with a negative or positive surface charge, depending on the relative concentrations of CS to gamma-PGA used. The NPs with a positive surface charge (or shelled with CS) could transiently open the tight junctions between Caco-2 cells and thus increased the paracellular permeability. After loading of insulin, the NPs remained spherical and the insulin release profiles were significantly affected by their stability in distinct pH environments. The in vivo results clearly indicated that the insulin-loaded NPs could effectively reduce the blood glucose level in a diabetic rat model.
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Cites
Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989) · Gastroenterology · doi:10.1016/s0016-5085(89)80072-1 · Cited by 2,396
Measurement of gastrointestinal pH profiles in normal ambulant human subjects
Evans, D. F., Pye, G., Bramley, R., Clark, A. G., Dyson, T. J., & Hardcastle, J. D. (1988) · Gut · doi:10.1136/gut.29.8.1035 · Cited by 1,240
Microencapsulated chitosan nanoparticles for lung protein delivery
Grenha, A., Seijo, B., & Remuñán-López, C. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2005.04.009 · Cited by 469
Chitosan and its derivatives as intestinal absorption enhancers
Thanou, M., Verhoef, J. C., & Junginger, H. E. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00180-6 · Cited by 430
Borchard, G., Lueβen, H. L., de Boer, A. G., Verhoef, J. C., Lehr, C.-M., & Junginger, H. E. (1996) · Journal of Controlled Release · doi:10.1016/0168-3659(95)00146-8 · Cited by 393
Matsumoto, A., Ikeda, S., Harada, A., & Kataoka, K. (2003) · Biomacromolecules · doi:10.1021/bm034139o · Cited by 351
Matsumoto, A., Yoshida, R., & Kataoka, K. (2004) · Biomacromolecules · doi:10.1021/bm0345413 · Cited by 338
van der Merwe, S. M., Verhoef, J. C., Verheijden, J. H. M., Kotzé, A. F., & Junginger, H. E. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.03.023 · Cited by 260
Emdin, S. O., Dodson, G. G., Cutfield, J. M., & Cutfield, S. M. (1980) · Diabetologia · doi:10.1007/bf00275265 · Cited by 257
Kotzé, A. F., Lueßen, H. L., de Leeuw, B. J., de Boer, (. G., Coos Verhoef, J., & Junginger, H. E. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00154-5 · Cited by 226
Ballard, S. T., Hunter, J. H., & Taylor, A. E. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.000343 · Cited by 194
Jeong, B., Lee, K. M., Gutowska, A., & An, Y. H. (2002) · Biomacromolecules · doi:10.1021/bm025536m · Cited by 152
Poly(glutamic Acid) for Biomedical Applications
Richard, A., & Margaritis, A. (2001) · Critical Reviews in Biotechnology · doi:10.1080/07388550108984171 · Cited by 135
Quaglia, F., Rosa, G. D., Granata, E., Ungaro, F., Fattal, E., & Rotonda, M. I. L. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00414-5 · Cited by 86
The absorption of insulin from various regions of the rat intestine
Kidron, M., Bar-On, H., Berry, E. M., & Ziv, E. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90673-7 · Cited by 84
In vitro degradation of insulin-loaded poly (n-butylcyanoacrylate) nanoparticles
Sullivan, C. O., & Birkinshaw, C. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2003.11.001 · Cited by 82
A method for direct preparation of chitosan with low molecular weight from fungi
Niederhofer, A., & Müller, B. W. (2003) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(03)00189-9 · Cited by 72
The degradation pathways of glucagon in acidic solutions
Joshi, A. B., Rus, E., & Kirsch, L. E. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00438-5 · Cited by 67
Poly-γ-glutamate synthetase of Bacillus subtilis
Ashiuchi, M., Kamei, T., & Misono, H. (2003) · Journal of Molecular Catalysis B Enzymatic · doi:10.1016/s1381-1177(03)00076-6 · Cited by 53
Cited by
Emerging micro- and nanotechnology based synthetic approaches for insulin delivery
Mo, R., Jiang, T., Di, J., Tai, W., & Gu, Z. (2014) · Chemical Society Reviews · doi:10.1039/c3cs60436e · Cited by 386
Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment.
Wong, C. Y., Al-Salami, H., & Dass, C. R. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.003 · Cited by 257
Aravamudhan, A., Ramos, D. M., Nada, A. A., & Kumbar, S. G. (2014) · Natural and Synthetic Biomedical Polymers · doi:10.1016/b978-0-12-396983-5.00004-1 · Cited by 238
Oral insulin delivery: how far are we?
Fonte, P., Araújo, F., Reis, S., & Sarmento, B. (2013) · Journal of Diabetes Science and Technology · doi:10.1177/193229681300700228 · Cited by 211
Li, L., Yu, M., Li, Y., Li, Q., Yang, H., Zheng, M., Han, Y., Lu, D., Lu, S., & Gui, L. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.10.018 · Cited by 148
Metadata
- Authors
- Lin, Y.-H., Mi, F.-L., Chen, C.-T., Chang, W.-C., Peng, S.-F., Liang, H.-F., & Sung, H.-W.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-12-08
- Volume
- 8
- Issue
- 1
- Pages
- 146-152
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W1986689667
- Cited by
- 349
- References
- 19
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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