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Rheology of Gastric Mucin Exhibits a pH-Dependent Sol−Gel Transition
Abstract
Gastric mucin, a high molecular weight glycoprotein, is responsible for providing the gel-forming properties and protective function of the gastric mucus layer. Bulk rheology measurements in the linear viscoelastic regime show that gastric mucin undergoes a pH-dependent sol-gel transition from a viscoelastic solution at neutral pH to a soft viscoelastic gel in acidic conditions, with the transition occurring near pH 4. In addition to pH-dependent gelation behavior in this system, further rheological studies under nonlinear deformations reveal shear thinning and an apparent yield stress in this material which are also highly influenced by pH.
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Citations
Cited by
Mucus as a Barrier to Drug Delivery – Understanding and Mimicking the Barrier Properties
Boegh, M., & Nielsen, H. M. (2015) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12342 · Cited by 384
Enzymatically active biomimetic micropropellers for the penetration of mucin gels
Walker, D., Käsdorf, B. T., Jeong, H.-H., Lieleg, O., & Fischer, P. (2015) · Science Advances · doi:10.1126/sciadv.1500501 · Cited by 331
Characterization of Particle Translocation through Mucin Hydrogels
Lieleg, O., Vladescu, I., & Ribbeck, K. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.01.012 · Cited by 306
Mucins as multifunctional building blocks of biomaterials
Petrou, G., & Crouzier, T. (2018) · Biomaterials Science · doi:10.1039/c8bm00471d · Cited by 198
Mucin biopolymers as broad-spectrum antiviral agents
Lieleg, O., Lieleg, C., Bloom, J., Buck, C. B., & Ribbeck, K. (2012) · Biomacromolecules · doi:10.1021/bm3001292 · Cited by 167
Metadata
- Authors
- Celli, J. P., Turner, B. S., Afdhal, N. H., Ewoldt, R. H., McKinley, G. H., Bansil, R., & Erramilli, S.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-04-03
- Volume
- 8
- Issue
- 5
- Pages
- 1580-1586
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2074645731
- Cited by
- 310
- References
- 0
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Celli, J. P., Turner, B. S., Afdhal, N. H., Ewoldt, R. H., McKinley, G. H., Bansil, R., & Erramilli, S. (2007). Rheology of Gastric Mucin Exhibits a pH-Dependent Sol−Gel Transition. Biomacromolecules. https://doi.org/10.1021/bm0609691
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