The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Synthesis and Biodegradation of Nanogels as Delivery Carriers for Carbohydrate Drugs
Abstract
Biodegradable nanogels loaded with rhodamine B isothiocyanate-dextran (RITC-Dx) as a model for water-soluble biomacromolecular drugs were prepared using atom-transfer radical polymerization (ATRP) in a cyclohexane inverse miniemulsion in the presence of a disulfide-functionalized dimethacrylate cross linker. UV-vis spectroscopy was used to characterize the extent of incorporation of RITC-Dx into the nanogels. The loading efficiency of RITC-Dx into the nanogels exceeded 80%. These nanogels were degraded into polymeric sols in a reducing environment to release the encapsulated carbohydrate drugs. The released carbohydrate biomolecules specifically interacted with concanavalin A in water, suggesting that the biodegradable nanogels could be used as carriers to deliver carbohydrate drugs that can be released upon degradation to bind to pathogens based on lectins.
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Cites
Controlled/living radical polymerization: Features, developments, and perspectives
Braunecker, W. A., & Matyjaszewski, K. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2006.11.002 · Cited by 3,202
Self-citationReaction Behavior of Biodegradable, Photo-Cross-Linkable Polyanhydrides
Muggli, D. S., Burkoth, A. K., Keyser, S. A., Lee, H. R., & Anseth, K. S. (1998) · Macromolecules · doi:10.1021/ma980108n · Cited by 107
Cited by
Atrp in the design of functional materials for biomedical applications
Siegwart, D. J., Oh, J. K., & Matyjaszewski, K. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.08.001 · Cited by 613
Self-citationBiodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery
Li, Y., Maciel, D., Rodrigues, J., Shi, X., & Tomás, H. (2015) · Chemical Reviews · doi:10.1021/cr500131f · Cited by 478
Oh, J. K., & Park, J. M. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.08.005 · Cited by 427
Self-citationPolymeric nanostructured materials for biomedical applications
Tang, Z., He, C., Tian, H., Ding, J., Hsiao, B. S., Chu, B., & Chen, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.05.005 · Cited by 363
Metadata
- Authors
- Oh, J. K., Siegwart, D. J., & Matyjaszewski, K.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-09-26
- Volume
- 8
- Issue
- 11
- Pages
- 3326-3331
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W1968265961
- Cited by
- 160
- References
- 2
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- closed
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