Atrp in the design of functional materials for biomedical applications
Open accessAbstract
Atom Transfer Radical Polymerization (ATRP) is an effective technique for the design and preparation of multifunctional, nanostructured materials for a variety of applications in biology and medicine. ATRP enables precise control over macromolecular structure, order, and functionality, which are important considerations for emerging biomedical designs. This article reviews recent advances in the preparation of polymer-based nanomaterials using ATRP, including polymer bioconjugates, block copolymer-based drug delivery systems, cross-linked microgels/nanogels, diagnostic and imaging platforms, tissue engineering hydrogels, and degradable polymers. It is envisioned that precise engineering at the molecular level will translate to tailored macroscopic physical properties, thus enabling control of the key elements for realized biomedical applications.
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Tremendous efforts have been devoted to developing novel ligands to minimize side reactions.
“Tremendous efforts have been devoted to developing novel ligands to minimize such side reactions [28].”
From Block Copolymers: Synthesis, Self-Assembly, and Applications (2017) · cites this paper as [28]
Section 2 (Method and mechanism of ATRP; page unavailable) says that low concentrations of active radicals minimize termination reactions. It does not say that researchers developed novel ligands to minimize side reactions. Searches for novel ligands, side reactions, and catalyst ligands found no passage making that connection. (LLM, conf=0.76)
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Jiao, Y., Niu, L.-N., Ma, S., Li, J., Tay, F. R., & Chen, J.-H. (2017) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2017.03.001 · Cited by 639 · see citing works
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Block Copolymers: Synthesis, Self-Assembly, and Applications
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“Tremendous efforts have been devoted to developing novel ligands to minimize such side reactions [28].”
BackgroundRecent developments in nanomaterial-based shear-sensitive drug delivery systems
Wang, Y., Pisapati, A. V., Zhang, X. F., & Cheng, X. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002196 · Cited by 44 · see citing works
Novel polymeric micelles for drug delivery: Material characterization and formulation screening
Janas, C., Mostaphaoui, Z., Schmiederer, L., Bauer, J., & Wacker, M. G. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.05.029 · Cited by 36 · see citing works
- Authors
- Siegwart, D. J., Oh, J. K., & Matyjaszewski, K.
- Affiliations
- Koch Institute for Integrative Cancer Research At MIT (US)
- Concordia University (CA)
- Carnegie Mellon University (US)
- Corresponding author
- Matyjaszewski, Krzysztof
- Venue
- Progress in Polymer Science
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 37
- Issue
- 1
- Pages
- 18-37
- ISSN
- 0079-6700 (ISSN-L)
- PMC
- PMC3604987
- OpenAlex
- W2050655524
- Cited by
- 613
- References
- 294
- Citations by year
- 2026: 12 · 2025: 28 · 2024: 26 · 2023: 22 · 2022: 36 · 2021: 41 · 2020: 29 · 2019: 47 · 2018: 44 · 2017: 43 · 2016: 57 · 2015: 62 · 2014: 58 · 2013: 65 · 2012: 37
- FWCI
- 24.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in Polymer Science (publishedVersion)
- PubMed (publishedVersion)
- Spectrum Research Repository (Concordia University) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Israel National Road Safety Authority (F32EB011867)
- Natural Sciences and Engineering Research Council of Canada
- National Science Foundation (DMR-09-69301)
- Canada Research Chairs
- Concordia University
- Korea Science and Engineering Foundation
- National Institute of Biomedical Imaging and Bioengineering
- Ministry of Education, Science and Technology (R33-10035-0)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- atom transfer radical polymerization, polymer nanomaterials, nanogels, degradable polymers, biomedical materials
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