Cited by 613Advanced Polymer Synthesis and CharacterizationHydrogels: synthesis, properties, applicationsPolymer Surface Interaction Studies

Atrp in the design of functional materials for biomedical applications

Open access
Siegwart, Daniel J., Oh, Jung Kwon, Matyjaszewski, Krzysztof·2012·Progress in Polymer Science

Abstract

Atom Transfer Radical Polymerization (ATRP) is an effective technique for the design and preparation of multifunctional, nanostructured materials for a variety of applications in biology and medicine. ATRP enables precise control over macromolecular structure, order, and functionality, which are important considerations for emerging biomedical designs. This article reviews recent advances in the preparation of polymer-based nanomaterials using ATRP, including polymer bioconjugates, block copolymer-based drug delivery systems, cross-linked microgels/nanogels, diagnostic and imaging platforms, tissue engineering hydrogels, and degradable polymers. It is envisioned that precise engineering at the molecular level will translate to tailored macroscopic physical properties, thus enabling control of the key elements for realized biomedical applications.

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Crossref · 10.1016/j.progpolymsci.2011.08.001

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  • Tremendous efforts have been devoted to developing novel ligands to minimize side reactions.

    “Tremendous efforts have been devoted to developing novel ligands to minimize such side reactions [28].”

    From Block Copolymers: Synthesis, Self-Assembly, and Applications (2017) · cites this paper as [28]

    Section 2 (Method and mechanism of ATRP; page unavailable) says that low concentrations of active radicals minimize termination reactions. It does not say that researchers developed novel ligands to minimize side reactions. Searches for novel ligands, side reactions, and catalyst ligands found no passage making that connection. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Authors
Siegwart, D. J., Oh, J. K., & Matyjaszewski, K.
Affiliations
  • Koch Institute for Integrative Cancer Research At MIT (US)
  • Concordia University (CA)
  • Carnegie Mellon University (US)
Corresponding author
Matyjaszewski, Krzysztof
Venue
Progress in Polymer Science
Publisher
Elsevier BV
Published
2012-01
Volume
37
Issue
1
Pages
18-37
ISSN
0079-6700 (ISSN-L)
OpenAlex
W2050655524
Cited by
613
References
294
Citations by year
2026: 12 · 2025: 28 · 2024: 26 · 2023: 22 · 2022: 36 · 2021: 41 · 2020: 29 · 2019: 47 · 2018: 44 · 2017: 43 · 2016: 57 · 2015: 62 · 2014: 58 · 2013: 65 · 2012: 37
FWCI
24.54
Type
journal article
Language
en
Open access
Locations
  • Progress in Polymer Science (publishedVersion)
  • PubMed (publishedVersion)
  • Spectrum Research Repository (Concordia University) (acceptedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Israel National Road Safety Authority (F32EB011867)
  • Natural Sciences and Engineering Research Council of Canada
  • National Science Foundation (DMR-09-69301)
  • Canada Research Chairs
  • Concordia University
  • Korea Science and Engineering Foundation
  • National Institute of Biomedical Imaging and Bioengineering
  • Ministry of Education, Science and Technology (R33-10035-0)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
Keywords
atom transfer radical polymerization, polymer nanomaterials, nanogels, degradable polymers, biomedical materials

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