The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Blood Compatible Graphene/Heparin Conjugate through Noncovalent Chemistry
Abstract
Blood compatible graphene/heparin conjugate is simply formulated through noncovalent interaction between chemically reduced graphene and heparin. Charge repulsion of negatively charged heparin on graphene plates renders hydrophobic graphene to be solublized in aqueous media without any precipitation or aggregation even after 6 months. Unfractioned heparin (UFH) with higher molecular weight was effective for graphene solubilization while low molecular weight heparin (LMWH) was not. Noncovalently interacting heparin chains on graphene plates preserve their anticoagulant activity after conjugation with graphene. Graphene/UFH conjugate shows much enhanced anti factor Xa (FXa) activity of 29.6 IU/mL compared with pristine graphene oxide (GO; 1.03 IU/mL).
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Cites
Kidane, A. G., Salacinski, H., Tiwari, A., Bruckdorfer, K. R., & Seifalian, A. M. (2004) · Biomacromolecules · doi:10.1021/bm0344553 · Cited by 166
Cited by
Luo, Y., Shen, H., Fang, Y., Cao, Y., Huang, J., Zhang, M., Dai, J., Shi, X., & Zhang, Z. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b00862 · Cited by 323
Interactions of graphene and graphene oxide with proteins and peptides
Zhang, Y., Wu, C., Guo, S., & Zhang, J. (2013) · Nanotechnology Reviews · doi:10.1515/ntrev-2012-0078 · Cited by 235
Metadata
- Authors
- Lee, D. Y., Khatun, Z., Lee, J.-H., Lee, Y.-K., & In, I.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-01-10
- Volume
- 12
- Issue
- 2
- Pages
- 336-341
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2039938393
- Cited by
- 202
- References
- 1
- FWCI
- 11.30
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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