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Triply Triggered Doxorubicin Release From Supramolecular Nanocontainers
Abstract
The synthesis of a supramolecular double hydrophilic block copolymer (DHBC) held together by cucurbit[8]uril (CB[8]) ternary complexation and its subsequent self-assembly into micelles is described. This system is responsive to multiple external triggers including temperature, pH and the addition of a competitive guest. The supramolecular block copolymer assembly consists of poly(N-isopropylacrylamide) (PNIPAAm) as a thermoresponsive block and poly(dimethylaminoethylmethacrylate) (PDMAEMA) as a pH-responsive block. Moreover, encapsulation and controlled drug release was demonstrated with this system using the chemotherapeutic drug doxorubicin (DOX). This triple stimuli-responsive DHBC micelle system represents an evolution over conventional double stimuli-responsive covalent diblock copolymer systems and displayed a significant reduction in the viability of HeLa cells upon triggered release of DOX from the supramolecular micellar nanocontainers.
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Citations
Cited by
Cucurbituril-Based Molecular Recognition
Barrow, S. J., Kasera, S., Rowland, M. J., del Barrio, J., & Scherman, O. A. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00341 · Cited by 1,898
Self-citationSupramolecular polymeric hydrogels
Appel, E. A., del Barrio, J., Loh, X. J., & Scherman, O. A. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35264h · Cited by 1,159
Self-citationZhou, J., Yu, G., & Huang, F. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00898d · Cited by 677
Ring-opening copolymerization (ROCOP): synthesis and properties of polyesters and polycarbonates
Paul, S., Zhu, Y., Romain, C., Brooks, R., Saini, P. K., & Williams, C. K. (2015) · Chemical Communications · doi:10.1039/c4cc10113h · Cited by 593
Yu, G., Zhou, X., Zhang, Z., Han, C., Mao, Z., Gao, C., & Huang, F. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3099905 · Cited by 486
Metadata
- Authors
- Loh, X. J., del Barrio, J., Toh, P. P. C., Lee, T.-C., Jiao, D., Rauwald, U., Appel, E. A., & Scherman, O. A.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-12-23
- Volume
- 13
- Issue
- 1
- Pages
- 84-91
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2029063312
- Cited by
- 180
- References
- 0
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Loh, X. J., del Barrio, J., Toh, P. P. C., Lee, T.-C., Jiao, D., Rauwald, U., Appel, E. A., & Scherman, O. A. (2012). Triply Triggered Doxorubicin Release From Supramolecular Nanocontainers. Biomacromolecules. https://doi.org/10.1021/bm201588m
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