The DOI matches its Crossref record.
Improved Biological Characteristics of Poly(l-Lactic Acid) Electrospun Membrane by Incorporation of Multiwalled Carbon Nanotubes/Hydroxyapatite Nanoparticles
Abstract
Significant effort has been devoted to fabricating various biomaterials to satisfy specific clinical requirements. In this study, we developed a new type of guided tissue regeneration (GTR) membrane by electrospinning a suspension consisting of poly( l-lactic acid), multiwalled carbon nanotubes, and hydroxyapatite (PLLA/MWNTs/HA). MWNTs/HA nanoparticles were uniformly dispersed in the membranes, and the degradation characteristics were far improved. Cytologic research revealed that the PLLA/MWNTs/HA membrane enhanced the adhesion and proliferation of periodontal ligament cells (PDLCs) by 30% and inhibited the adhesion and proliferation of gingival epithelial cells by 30% also, compared with the control group. After PDLCs were seeded into the PLLA/MWNTs/HA membrane, cell/membrane composites were implanted into the leg muscle pouches of immunodeficient mice. Histologic examinations showed that PDLCs attached on the membranes functioned well in vivo. This new type of membrane shows excellent dual biological functions and satisfied the requirement of the GTR technique successfully in spite of a monolayer structure. Compared with other GTR membranes on sale or in research, the membrane can simplify the manufacturing process, reduce the fabrication cost, and avoid possible mistakes in clinical application. Moreover, it does not need to be taken out after surgery. PLLA/MWNTs/HA membranes have shown great potential for GTR and tissue engineering.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Fluorescent PLLA-nanodiamond composites for bone tissue engineering
Zhang, Q., Mochalin, V. N., Neitzel, I., Knoke, I. Y., Han, J., Klug, C. A., Zhou, J. G., Lelkes, P. I., & Gogotsi, Y. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.090 · Cited by 399
Luo, Y., Shen, H., Fang, Y., Cao, Y., Huang, J., Zhang, M., Dai, J., Shi, X., & Zhang, Z. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b00862 · Cited by 323
The Use of Lactide Polymers in Bone Tissue Regeneration in Dentistry—A Systematic Review
Rajewska, J., Kowalski, J., Matys, J., Dobrzyński, M., & Wiglusz, R. J. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14020083 · Cited by 20
Metadata
- Authors
- Mei, F., Zhong, J., Yang, X., Ouyang, X., Zhang, S., Hu, X., Ma, Q., Lu, J., Ryu, S., & Deng, X.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-11-19
- Volume
- 8
- Issue
- 12
- Pages
- 3729-3735
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W1988357035
- Cited by
- 160
- References
- 0
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Improved Biological Characteristics of Poly(l-Lactic Acid) Electrospun Membrane by Incorporation of Multiwalled Carbon Nanotubes/Hydroxyapatite Nanoparticles. https://app.cochat.ai/papers/10.1021/bm7006295
- The paper
- Mei, F., Zhong, J., Yang, X., Ouyang, X., Zhang, S., Hu, X., Ma, Q., Lu, J., Ryu, S., & Deng, X. (2007). Improved Biological Characteristics of Poly(l-Lactic Acid) Electrospun Membrane by Incorporation of Multiwalled Carbon Nanotubes/Hydroxyapatite Nanoparticles. Biomacromolecules. https://doi.org/10.1021/bm7006295
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
