The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Zwitterionic Polymers Exhibiting High Resistance to Nonspecific Protein Adsorption from Human Serum and Plasma
Abstract
This study examined six different polymer and self-assembled monolayer (SAM) surface modifications for their interactions with human serum and plasma. It was demonstrated that zwitterionic polymer surfaces are viable alternatives to more traditional surfaces based on poly(ethylene glycol) (PEG) as nonfouling surfaces. All polymer surfaces were formed using atom transfer radical polymerization (ATRP) and they showed an increased resistance to nonspecific protein adsorption compared to SAMs. This improvement is due to an increase in the surface packing density of nonfouling groups on the surface, as well as a steric repulsion from the flexible polymer brush surfaces. The zwitterionic polymer surface based on carboxybetaine methacrylate (CBMA) also incorporates functional groups for protein immobilization in the nonfouling background, making it a strong candidate for many applications such as in diagnostics and drug delivery.
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Cites
A Survey of Structure−Property Relationships of Surfaces that Resist the Adsorption of Protein
Ostuni, E., Chapman, R. G., Holmlin, R. E., Takayama, S., & Whitesides, G. M. (2001) · Langmuir · doi:10.1021/la010384m · Cited by 1,799
Cited by
Physical hydrogels composed of polyampholytes demonstrate high toughness and viscoelasticity
Sun, T. L., Kurokawa, T., Kuroda, S., Ihsan, A. B., Akasaki, T., Sato, K., Haque, M. A., Nakajima, T., & Gong, J. P. (2013) · Nature Materials · doi:10.1038/nmat3713 · Cited by 2,089
Walkey, C. D., & Chan, W. C. W. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15233e · Cited by 1,758
Barbey, R., Lavanant, L., Paripovic, D., Schüwer, N., Sugnaux, C., Tugulu, S., & Klok, H.-A. (2009) · Chemical Reviews · doi:10.1021/cr900045a · Cited by 1,753
Zwitterionic hydrogels implanted in mice resist the foreign-body reaction
Zhang, L., Cao, Z., Bai, T., Carr, L., Ella-Menye, J.-R., Irvin, C., Ratner, B. D., & Jiang, S. (2013) · Nature Biotechnology · doi:10.1038/nbt.2580 · Cited by 1,035
Self-citationDuan, X., & Li, Y. (2013) · Small · doi:10.1002/smll.201201390 · Cited by 926
Metadata
- Authors
- Ladd, J., Zhang, Z., Chen, S., Hower, J. C., & Jiang, S.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-04-01
- Volume
- 9
- Issue
- 5
- Pages
- 1357-1361
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2074469051
- Cited by
- 808
- References
- 1
- FWCI
- 17.19
- Type
- journal article
- Language
- en
- Open access
- closed
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