Cited by 75Advanced Polymer Synthesis and CharacterizationBlock Copolymer Self-AssemblySurfactants and Colloidal Systems

Morphological Control of Poly(ethylene glycol)-block-poly(ε-caprolactone) Copolymer Aggregates in Aqueous Solution

Fairley, Nichole, Hoang, Bryan, Allen, Christine·2008·Biomacromolecules

Abstract

In aqueous solution, it was found that the amphiphilic copolymer poly(ethylene glycol)-b-poly(caprolactone) (PEG(5000)-b-PCL(4100)) formed different morphologies, including long rod-like, short rod-like, or spherical aggregates, when the copolymer concentration was increased. Nearly identical morphologies were observed with the addition of increasing amounts of PEG(2000)-distearoylphosphoethanolamine (PEG(2000)-DSPE) to the copolymer. The morphologies of the aggregates in solution were confirmed by negative stain transmission electron microscopy (TEM) and cryogenic-TEM (cryo-TEM). The critical micelle concentrations of the PEG(5000)-b-PCL(4100) copolymer, PEG(2000)-DSPE and a mixture of the two materials (PEG(5000)-b-PCL 4100/PEG(2000)-DSPE) were evaluated to determine the thermodynamic stability of the aggregates. Differential scanning calorimetry was performed to gain insight into the degree of mixing of PEG(5000)-b-PCL(4100) and PEG(2000)-DSPE. Overall, combining PEG(5000)-b-PCL(4100) and PEG(2000)-DSPE produced a single population of mixed micelles with rod-like or spherical morphologies depending on the material composition and concentration.

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Crossref · 10.1021/bm800572p

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Authors
Fairley, N., Hoang, B., & Allen, C.
Affiliations
University of Toronto (CA)
Corresponding author
Allen, Christine
Venue
Biomacromolecules
Published
2008-08-15
Volume
9
Issue
9
Pages
2283-2291
ISSN
  • 1525-7797 (ISSN-L)
  • 1526-4602
OpenAlex
W2012787296
Cited by
75
References
50
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 8 · 2016: 5 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 8
FWCI
2.65
Type
journal article
Language
en
Open access
closed
Locations
  • Biomacromolecules (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
  • Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
Keywords
amphiphilic block copolymers, micelle morphology, mixed micelles, critical micelle concentration, thermodynamic stability, rod-like micelles, spherical micelles
MeSH terms
Calorimetry, Differential Scanning, Ethylene Glycols, Micelles, Molecular Weight, Particle Size, Polyesters, Solutions, Surface Properties, Temperature, Thermodynamics, Water

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