Morphological Control of Poly(ethylene glycol)-block-poly(ε-caprolactone) Copolymer Aggregates in Aqueous Solution
Abstract
In aqueous solution, it was found that the amphiphilic copolymer poly(ethylene glycol)-b-poly(caprolactone) (PEG(5000)-b-PCL(4100)) formed different morphologies, including long rod-like, short rod-like, or spherical aggregates, when the copolymer concentration was increased. Nearly identical morphologies were observed with the addition of increasing amounts of PEG(2000)-distearoylphosphoethanolamine (PEG(2000)-DSPE) to the copolymer. The morphologies of the aggregates in solution were confirmed by negative stain transmission electron microscopy (TEM) and cryogenic-TEM (cryo-TEM). The critical micelle concentrations of the PEG(5000)-b-PCL(4100) copolymer, PEG(2000)-DSPE and a mixture of the two materials (PEG(5000)-b-PCL 4100/PEG(2000)-DSPE) were evaluated to determine the thermodynamic stability of the aggregates. Differential scanning calorimetry was performed to gain insight into the degree of mixing of PEG(5000)-b-PCL(4100) and PEG(2000)-DSPE. Overall, combining PEG(5000)-b-PCL(4100) and PEG(2000)-DSPE produced a single population of mixed micelles with rod-like or spherical morphologies depending on the material composition and concentration.
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Cryo-TEM images allowed appreciation of the influence of the hydrophobic block composition on micelles morphology and observation of dexamethasone in the micellar core, confirming drug loading.
“Thanks to the cryo-TEM images (Fig. 7) it was possible to appreciate the influence of the composition of the hydrophobic block on micelles morphology, and to observe dexamethasone in the micellar core, confirming drug loading in the nanocarrier.”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [175]
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- Authors
- Fairley, N., Hoang, B., & Allen, C.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Allen, Christine
- ORCID
- Allen, Christine
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-08-15
- Volume
- 9
- Issue
- 9
- Pages
- 2283-2291
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2012787296
- Cited by
- 75
- References
- 50
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 8 · 2016: 5 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 8
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomacromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
- Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
- Keywords
- amphiphilic block copolymers, micelle morphology, mixed micelles, critical micelle concentration, thermodynamic stability, rod-like micelles, spherical micelles
- MeSH terms
- Calorimetry, Differential Scanning, Ethylene Glycols, Micelles, Molecular Weight, Particle Size, Polyesters, Solutions, Surface Properties, Temperature, Thermodynamics, Water
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