The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Fifty Years of Diazeniumdiolate Research. From Laboratory Curiosity to Broad-Spectrum Biomedical Advances
Open accessAbstract
Here I show that a "pure" research project, seemingly totally lacking in practical application when it was first published, can years later spark a whole new scientific field with the potential to revolutionize clinical practice. A 1961 publication describing adducts of nitric oxide (NO) with certain nucleophiles attracted little notice at the time, but later work showing that the adducts could be hydrolyzed to regenerate the NO in bioactive form has provided the foundation for a host of biomedical applications. Crucial to the discovery of widely used tools for studying NO's chemical biology as well as for the design of a variety of promising therapeutic advances has been the increasingly detailed understanding of the physicochemical properties of these "diazeniumdiolates" (also known as NONOates).
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Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
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Maragos, C. M., Morley, D., Wink, D. A., Dunams, T. M., Saavedra, J. E., Hoffman, A., Bove, A. A., Isaac, L., Hrabie, J. A., & Keefer, L. K. (1991) · Journal of Medicinal Chemistry · doi:10.1021/jm00115a013 · Cited by 722
Self-citationKeefer, L. K., Nims, R. W., Davies, K. M., & Wink, D. A. (1996) · Methods in Enzymology · doi:10.1016/s0076-6879(96)68030-6 · Cited by 670
Self-citationMiranda, K. M., Paolocci, N., Katori, T., Thomas, D. D., Ford, E., Bartberger, M. D., Espey, M. G., Kass, D. A., Feelisch, M., Fukuto, J. M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1430507100 · Cited by 283
Nitric Oxide-Releasing Polymers Containing the [N(O)NO]-Group
Smith, D. J., Chakravarthy, D., Pulfer, S., Simmons, M. L., Hrabie, J. A., Citro, M. L., Saavedra, J. E., Davies, K. M., Hutsell, T. C., Mooradian, D. L., et al. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm950652b · Cited by 208
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Huang, Z., Fu, J., & Zhang, Y. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01672 · Cited by 406
Progress and Promise of Nitric Oxide‐Releasing Platforms
Yang, T., Zelikin, A. N., & Chandrawati, R. (2018) · Advanced Science · doi:10.1002/advs.201701043 · Cited by 309
Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases
Barraud, N., Kelso, M., Rice, S., & Kjelleberg, S. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140905112822 · Cited by 255
Nitric oxide–releasing macromolecular scaffolds for antibacterial applications
Yang, L., Feura, E. S., Ahonen, M. J. R., & Schoenfisch, M. H. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800155 · Cited by 218
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Metadata
- Authors
- Keefer, L. K.
- Venue
- ACS Chemical Biology
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-09-30
- Volume
- 6
- Issue
- 11
- Pages
- 1147-1155
- ISSN
- 1554-8929 (ISSN-L)
- 1554-8937
- OpenAlex
- W1993601025
- Cited by
- 182
- References
- 5
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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