Nitric oxide–releasing macromolecular scaffolds for antibacterial applications
Open accessAbstract
Exogenous nitric oxide (NO) represents an attractive antibacterial agent because of its ability to both disperse and directly kill bacterial biofilms while avoiding resistance. Due to the challenges associated with administering gaseous NO, NO‐releasing macromolecular scaffolds are developed to facilitate NO delivery. This progress report describes the rational design and application of NO‐releasing macromolecular scaffolds as antibacterial therapeutics. Special consideration is given to the role of the physicochemical properties of the NO storage vehicles on antibacterial or anti‐biofilm activity.
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Greater bactericidal activity is observed when •NO and H2O2 act synergistically, compared to •NO alone.
“Greater bactericidal activity is observed when •NO and H2O2 act synergistically, compared to •NO alone [130].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [130]
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- Authors
- Yang, L., Feura, E. S., Ahonen, M. J. R., & Schoenfisch, M. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Schoenfisch, Mark H.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2018-05-14
- Volume
- 7
- Issue
- 13
- Pages
- e1800155-e1800155
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- PMC
- PMC6159924
- OpenAlex
- W2803124751
- Cited by
- 218
- References
- 160
- Citations by year
- 2026: 18 · 2025: 38 · 2024: 38 · 2023: 29 · 2022: 30 · 2021: 31 · 2020: 19 · 2019: 12 · 2018: 2 · 2016: 1
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Healthcare Materials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AI112029, DE025207)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- nitric oxide, antibacterial therapeutics, bacterial biofilms, physicochemical properties, antibiotic resistance
- MeSH terms
- Anti-Bacterial Agents, Humans, Liposomes, Molecular Weight, Nitrates, Nitric Oxide, Polymers, Surface Properties, Biofilms, Nitric Oxide Donors, Macromolecular Substances, Nanoparticles
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