Cited by 218Antimicrobial agents and applicationsBacterial biofilms and quorum sensingNitric Oxide and Endothelin Effects

Nitric oxide–releasing macromolecular scaffolds for antibacterial applications

Open access
Yang, Lei, Feura, Evan S., Ahonen, Mona Jasmine R., Schoenfisch, Mark H.·2018·Advanced Healthcare Materials

Abstract

Exogenous nitric oxide (NO) represents an attractive antibacterial agent because of its ability to both disperse and directly kill bacterial biofilms while avoiding resistance. Due to the challenges associated with administering gaseous NO, NO‐releasing macromolecular scaffolds are developed to facilitate NO delivery. This progress report describes the rational design and application of NO‐releasing macromolecular scaffolds as antibacterial therapeutics. Special consideration is given to the role of the physicochemical properties of the NO storage vehicles on antibacterial or anti‐biofilm activity.

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Integrity signals

Registry

Crossref · 10.1002/adhm.201800155

Cites

158 of 158 references verified0 citation errors · 0 not checkable

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  • Greater bactericidal activity is observed when •NO and H2O2 act synergistically, compared to •NO alone.

    “Greater bactericidal activity is observed when •NO and H2O2 act synergistically, compared to •NO alone [130].”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [130]

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Cites

1 retracted

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2 of the 160 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Marcato P. D., 2013, Curr. Nanosci., 9, 1
  2. 10.1021/ja3022736 · DOI
  3. Nurhasni H., 2015, Int. J. Nanomed., 10, 3065

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Authors
Yang, L., Feura, E. S., Ahonen, M. J. R., & Schoenfisch, M. H.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
Schoenfisch, Mark H.
Venue
Advanced Healthcare Materials
Publisher
Wiley
Published
2018-05-14
Volume
7
Issue
13
Pages
e1800155-e1800155
ISSN
  • 2192-2640 (ISSN-L)
  • 2192-2659
OpenAlex
W2803124751
Cited by
218
References
160
Citations by year
2026: 18 · 2025: 38 · 2024: 38 · 2023: 29 · 2022: 30 · 2021: 31 · 2020: 19 · 2019: 12 · 2018: 2 · 2016: 1
FWCI
1.09
Type
journal article
Language
en
Open access
Locations
  • Advanced Healthcare Materials (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (AI112029, DE025207)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
nitric oxide, antibacterial therapeutics, bacterial biofilms, physicochemical properties, antibiotic resistance
MeSH terms
Anti-Bacterial Agents, Humans, Liposomes, Molecular Weight, Nitrates, Nitric Oxide, Polymers, Surface Properties, Biofilms, Nitric Oxide Donors, Macromolecular Substances, Nanoparticles

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