“NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms
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Diazeniumdiolate compounds may form carcinogenic nitrosamines.
“One drawback of the diazeniumdiolate compounds is that they may potentially form carcinogenic nitrosamines.151,152”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [152]
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- Authors
- Keefer, L. K., Nims, R. W., Davies, K. M., & Wink, D. A.
- Affiliations
- Frederick National Laboratory for Cancer Research (US)
- Venue
- Methods in Enzymology
- Publisher
- Elsevier
- Published
- 1996
- Volume
- 268
- Pages
- 281-293
- ISSN
- 0076-6879 (ISSN-L)
- OpenAlex
- W1512538844
- Cited by
- 670
- References
- 16
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 7 · 2023: 9 · 2022: 10 · 2021: 18 · 2020: 14 · 2019: 18 · 2018: 24 · 2017: 12 · 2016: 24 · 2015: 22 · 2014: 27 · 2013: 26 · 2012: 30
- FWCI
- 20.87
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Methods in enzymology on CD-ROM/Methods in enzymology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Physical Sciences › Chemistry › Organic Chemistry › Structural and Chemical Analysis of Organic and Inorganic Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- diazeniumdiolates, nitric oxide donors, NONOates, quality control, nomenclature, physicochemical properties
- MeSH terms
- Chemistry, Drug Stability, Enzyme Inhibitors, Imides, Indicators and Reagents, Kinetics, Nitric Oxide, Quality Control, Structure-Activity Relationship, Molecular Structure, Cytochrome P-450 Enzyme Inhibitors
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