The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease
Abstract
Protein misfolding and metal ion dyshomeostasis are believed to underlie numerous neurodegenerative diseases, including Alzheimer's disease (AD). The pathological hallmark of AD is accumulation of misfolded amyloid-β (Aβ) peptides and hyperphosphorylated tau (ptau) proteins in the brain. Since AD etiology remains unclear, several hypotheses have emerged to elucidate its pathological pathways. The amyloid cascade hypothesis, a leading hypothesis for AD development, advocates Aβ as the principal culprit. Additionally, evidence suggests that tau may contribute to AD pathology. Aβ and tau have also been shown to impact each other's pathology either directly or indirectly. Furthermore, metal ion dyshomeostasis is associated with these misfolded proteins. Metal interactions with Aβ and tau/ptau also influence their aggregation properties and neurotoxicity. Herein, we present current understanding on the roles of Aβ, tau, and metal ions, placing equal emphasis on each of these proposed features, as well as their inter-relationships in AD pathogenesis.
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1 retracted
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
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Cited by
Synthetic fluorescent probes for studying copper in biological systems
Cotruvo, Jr., Aron, A. T., Ramos-Torres, K. M., & Chang, C. J. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00346b · Cited by 558
Heavy Metals and Metalloids As a Cause for Protein Misfolding and Aggregation
Tamás, M., Sharma, S., Ibstedt, S., Jacobson, T., & Christen, P. (2014) · Biomolecules · doi:10.3390/biom4010252 · Cited by 468
Chemically diverse small molecule fluorescent chemosensors for copper ion
Sivaraman, G., Iniya, M., Anand, T., Kotla, N. G., Sunnapu, O., Singaravadivel, S., Gulyani, A., & Chellappa, D. (2018) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.11.020 · Cited by 391
The biological pathways of Alzheimer disease: a review
Calabrò, M., Department of Biomedical and Dental Sciences and Morphofunctional Imaging, U. O. M., Rinaldi, C., Santoro, G., & Crisafulli, C. (2021) · AIMS Neuroscience · doi:10.3934/neuroscience.2021005 · Cited by 265
Rajasekhar, K., & Govindaraju, T. (2018) · RSC Advances · doi:10.1039/c8ra03620a · Cited by 150
Metadata
- Authors
- Savelieff, M. G., Lee, S., Liu, Y., & Lim, M. H.
- Venue
- ACS Chemical Biology
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-03-18
- Volume
- 8
- Issue
- 5
- Pages
- 856-865
- ISSN
- 1554-8929 (ISSN-L)
- 1554-8937
- OpenAlex
- W2029119021
- Cited by
- 400
- References
- 100
- FWCI
- 17.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Savelieff, M. G., Lee, S., Liu, Y., & Lim, M. H. (2013). Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease. ACS Chemical Biology. https://doi.org/10.1021/cb400080f
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
