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Cited by 400

The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

Savelieff, Masha G., Lee, Sanghyun, Liu, Yuzhong, Lim, Mi Hee·2013·ACS Chemical Biology
DOI 10.1021/cb400080f
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Abstract

Protein misfolding and metal ion dyshomeostasis are believed to underlie numerous neurodegenerative diseases, including Alzheimer's disease (AD). The pathological hallmark of AD is accumulation of misfolded amyloid-β (Aβ) peptides and hyperphosphorylated tau (ptau) proteins in the brain. Since AD etiology remains unclear, several hypotheses have emerged to elucidate its pathological pathways. The amyloid cascade hypothesis, a leading hypothesis for AD development, advocates Aβ as the principal culprit. Additionally, evidence suggests that tau may contribute to AD pathology. Aβ and tau have also been shown to impact each other's pathology either directly or indirectly. Furthermore, metal ion dyshomeostasis is associated with these misfolded proteins. Metal interactions with Aβ and tau/ptau also influence their aggregation properties and neurotoxicity. Herein, we present current understanding on the roles of Aβ, tau, and metal ions, placing equal emphasis on each of these proposed features, as well as their inter-relationships in AD pathogenesis.

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Metadata

Authors
Savelieff, M. G., Lee, S., Liu, Y., & Lim, M. H.
Venue
ACS Chemical Biology
Publisher
American Chemical Society (ACS)
Published
2013-03-18
Volume
8
Issue
5
Pages
856-865
ISSN
  • 1554-8929 (ISSN-L)
  • 1554-8937
DOI
10.1021/cb400080f
OpenAlex
W2029119021
Cited by
400
References
100
FWCI
17.95
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.