Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

Rajasekhar, K.; Govindaraju, Thimmaiah

doi:10.1039/c8ra03620a

Cited by 154Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchCholinesterase and Neurodegenerative Diseases

Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

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Rajasekhar, K., Govindaraju, Thimmaiah·2018·RSC Advances

DOI 10.1039/c8ra03620aPMC PMC9081849

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Abstract

The diverse pathological mechanisms and their implications for the development of effective diagnostic and therapeutic interventions in Alzheimer's disease are presented with current progress, challenges and future prospects.

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Various growing factors for Alzheimer's disease like presenilin 1 proteins, oxidative stress, and tau neurofibrillary tangles can cause dysfunction of autophagic vacuoles and hence can contribute in the pathogenesis of Alzheimer's disease.
“Various growing factors for AD like presenelin 1 proteins, oxidative stress, tau neurofibrillary tangles can cause dysfunction of autophagic vacuoles and hence can contribute in the pathogenesis of AD [32, 33].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [32]

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Authors: Rajasekhar, K., & Govindaraju, T.
Affiliations: Jawaharlal Nehru Centre for Advanced Scientific Research (IN)
Corresponding author: Govindaraju, Thimmaiah
ORCID: Rajasekhar, K.
Govindaraju, Thimmaiah
Venue: RSC Advances
Publisher: Royal Society of Chemistry (RSC)
Published: 2018
Volume: 8
Issue: 42
Pages: 23780-23804
ISSN: 2046-2069 (ISSN-L)
DOI: 10.1039/c8ra03620a
PMC: PMC9081849
OpenAlex: W2811135471
Cited by: 150
References: 158
Citations by year: 2026: 4 · 2025: 16 · 2024: 27 · 2023: 20 · 2022: 17 · 2021: 24 · 2020: 25 · 2019: 13 · 2018: 4
FWCI: 2.17
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/3.0/ (vor, 179 d)
Locations: RSC Advances (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: Department of Science and Technology, Ministry of Science and Technology (DST/SJF/CSA-02/2015-2016)
Sheikh Saqr Laboratory
Jawaharlal Nehru Centre for Advanced Scientific Research
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords: Alzheimer's disease, Alzheimer's disease pathogenesis, early diagnosis, therapeutic interventions, drug development, neurotoxicity, clinical trials

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