The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Scaffold Architecture and Pharmacophoric Properties of Natural Products and Trade Drugs: Application in the Design of Natural Product-Based Combinatorial Libraries
Abstract
Natural products were analyzed to determine whether they contain appealing novel scaffold architectures for potential use in combinatorial chemistry. Ring systems were extracted and clustered on the basis of structural similarity. Several such potential scaffolds for combinatorial chemistry were identified that are not present in current trade drugs. For one of these scaffolds a virtual combinatorial library was generated. Pharmacophoric properties of natural products, trade drugs, and the virtual combinatorial library were assessed using a self-organizing map. Obviously, current trade drugs and natural products have several topological pharmacophore patterns in common. These features can be systematically explored with selected combinatorial libraries based on a combination of natural product-derived and synthetic molecular building blocks.
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Citations
Cites
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A Scoring Scheme for Discriminating between Drugs and Nondrugs
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Cited by
The evolving role of natural products in drug discovery
Koehn, F. E., & Carter, G. T. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1657 · Cited by 2,572
Privileged scaffolds for library design and drug discovery
Welsch, M. E., Snyder, S. A., & Stockwell, B. R. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.02.018 · Cited by 1,509
Counting on natural products for drug design
Rodrigues, T., Reker, D., Schneider, P., & Schneider, G. (2016) · Nature Chemistry · doi:10.1038/nchem.2479 · Cited by 1,250
Self-citationNew aspects of natural products in drug discovery
Lam, K. S. (2007) · Trends in Microbiology · doi:10.1016/j.tim.2007.04.001 · Cited by 531
The application of in silico drug-likeness predictions in pharmaceutical research
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Metadata
- Authors
- Lee, M.-L., & Schneider, G.
- Venue
- Journal of Combinatorial Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2001-04-12
- Volume
- 3
- Issue
- 3
- Pages
- 284-289
- ISSN
- 1520-4766 (ISSN-L)
- 1520-4774
- OpenAlex
- W1969921890
- Cited by
- 293
- References
- 5
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, M.-L., & Schneider, G. (2001). Scaffold Architecture and Pharmacophoric Properties of Natural Products and Trade Drugs: Application in the Design of Natural Product-Based Combinatorial Libraries. Journal of Combinatorial Chemistry. https://doi.org/10.1021/cc000097l
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