The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Nanochemistry: Synthesis and Characterization of Multifunctional Nanoclinics for Biological Applications
Abstract
This paper presents the use of nanoscale chemistry to synthesize a multilevel, hierarchically built nanoparticle, which we define as a nanoclinic, for targeted diagnostics and therapy. This nanoclinic, produced by multistep chemistry in a nanosize micelle, consists of a thin silica shell encapsulating magnetic (Fe 2 O 3 ) nanoparticles and fluorescent dyes for enhanced contrast magnetic resonance and optical imaging and magnetic-induced cancer therapy. Furthermore, the surface of these prototype nanoclinics is functionalized with a biotargeting group, luteinizing hormone-releasing hormone (LH−RH). In the work reported here, the LH−RH targets receptor-specific cancer cells for utilization in imaging and investigation of biological effects. The structure and function of these nanoclinics have been characterized using electron and X-ray diffractions, transmission electron microscopy, atomic force and scanning electron microscopy and two-photon laser scanning microscopy. Targeting of the receptor-specific cells has been demonstrated, along with the demonstration of a new mechanism of selective destruction of cancer cells, in a dc magnetic field, using these magnetic nanoclinics.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bean, C. P., & Livingston, J. D. (1959) · Journal of Applied Physics · doi:10.1063/1.2185850 · Cited by 1,773
Bilayer Surfactant Stabilized Magnetic Fluids: Synthesis and Interactions at Interfaces
Shen, L., Laibinis, P. E., & Hatton, T. A. (1999) · Langmuir · doi:10.1021/la9807661 · Cited by 545
Clark, H. A., Hoyer, M., Philbert, M. A., & Kopelman, R. (1999) · Analytical Chemistry · doi:10.1021/ac990629o · Cited by 355
Clark, H. A., Kopelman, R., Tjalkens, R., & Philbert, M. A. (1999) · Analytical Chemistry · doi:10.1021/ac990630n · Cited by 321
Sonochemical Synthesis of Functionalized Amorphous Iron Oxide Nanoparticles
Shafi, K. V. P. M., Ulman, A., Yan, X., Yang, N.-L., Estournès, C., White, H., & Rafailovich, M. (2001) · Langmuir · doi:10.1021/la010421+ · Cited by 209
Nanoparticles and microparticles for drug and vaccine delivery.
Kreuter, J. (1996) · Europe PMC (PubMed Central) · Cited by 204
Antitumor Immunity Induction by Intracellular Hyperthermia Using Magnetite Cationic Liposomes
Yanase, M., Shinkai, M., Honda, H., Wakabayashi, T., Yoshida, J., & Kobayashi, T. (1998) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1998.tb03283.x · Cited by 181
Schütt, W., Grüttner, C., Häfeli, U. O., Zborowski, M., Teller, J., Putzar, H., & Schümichen, C. (1997) · Hybridoma · doi:10.1089/hyb.1997.16.109 · Cited by 109
Nanoparticles as Adjuvants for Vaccines
Kreuter, J. (1995) · Pharmaceutical biotechnology · doi:10.1007/978-1-4615-1823-5_19 · Cited by 58
Cited by
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy
Chen, G., Roy, I., Yang, C., & Prasad, P. N. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00148 · Cited by 1,499
Self-citationSuperparamagnetic Colloids: Controlled Synthesis and Niche Applications
Jeong, U., Teng, X., Wang, Y., Yang, H., & Xia, Y. (2007) · Advanced Materials · doi:10.1002/adma.200600674 · Cited by 982
Roy, I., Ohulchanskyy, T. Y., Pudavar, H. E., Bergey, E. J., Oseroff, A. R., Morgan, J., Dougherty, T. J., & Prasad, P. N. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0343095 · Cited by 929
Self-citationMotornov, M., Roiter, Y., Tokarev, I., & Minko, S. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.10.004 · Cited by 773
Small particles, big impacts: A review of the diverse applications of nanofluids
Taylor, R., Coulombe, S., Otanicar, T., Phelan, P., Gunawan, A., Lv, W., Rosengarten, G., Prasher, R., & Tyagi, H. (2013) · Journal of Applied Physics · doi:10.1063/1.4754271 · Cited by 759
Multifunctional Magnetic-fluorescent Nanocomposites for Biomedical Applications
Corr, S. A., Rakovich, Y. P., & Gun’ko, Y. K. (2008) · Nanoscale Research Letters · doi:10.1007/s11671-008-9122-8 · Cited by 488
Aqueous Ferrofluid of Magnetite Nanoparticles: Fluorescence Labeling and Magnetophoretic Control
Sahoo, Y., Goodarzi, A., Swihart, M. T., Ohulchanskyy, T. Y., Kaur, N., Furlani, E. P., & Prasad, P. N. (2005) · The Journal of Physical Chemistry B · doi:10.1021/jp045402y · Cited by 422
Self-citationNanotechnology, nanotoxicology, and neuroscience
Suh, W. H., Suslick, K. S., Stucky, G. D., & Suh, Y.-H. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.009 · Cited by 406
Nanomaterials and singlet oxygen photosensitizers: potential applications in photodynamic therapy
Wang, S., Gao, R., Zhou, F., & Selke, M. (2004) · Journal of Materials Chemistry · doi:10.1039/b311429e · Cited by 384
Nanoparticle Architectures Templated by SiO2/Fe2O3 Nanocomposites
Yi, D. K., Lee, S. S., Papaefthymiou, G. C., & Ying, J. Y. (2006) · Chemistry of Materials · doi:10.1021/cm0512979 · Cited by 381
Magnetite Nanocrystals: Nonaqueous Synthesis, Characterization, and Solubility
Pinna, N., Grancharov, S., Beato, P., Bonville, P., Antonietti, M., & Niederberger, M. (2005) · Chemistry of Materials · doi:10.1021/cm050060+ · Cited by 355
Surface modification of Fe3O4@SiO2 microsphere by silane coupling agent
Ahangaran, F., Hassanzadeh, A., & Nouri, S. (2013) · International Nano Letters · doi:10.1186/2228-5326-3-23 · Cited by 310
van Schooneveld, M. M., Vucic, E., Koole, R., Zhou, Y., Stocks, J., Cormode, D. P., Tang, C. Y., Gordon, R. E., Nicolay, K., Meijerink, A., et al. (2008) · Nano Letters · doi:10.1021/nl801596a · Cited by 256
Metadata
- Authors
- Levy, L., Sahoo, Y., Kim, K.-S., Bergey, E. J., & Prasad, P. N.
- Venue
- Chemistry of Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-08-09
- Volume
- 14
- Issue
- 9
- Pages
- 3715-3721
- ISSN
- 0897-4756 (ISSN-L)
- 1520-5002
- OpenAlex
- W2050210241
- Cited by
- 320
- References
- 9
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
