The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Nanochemistry: Synthesis and Characterization of Multifunctional Nanoclinics for Biological Applications
Abstract
This paper presents the use of nanoscale chemistry to synthesize a multilevel, hierarchically built nanoparticle, which we define as a nanoclinic, for targeted diagnostics and therapy. This nanoclinic, produced by multistep chemistry in a nanosize micelle, consists of a thin silica shell encapsulating magnetic (Fe 2 O 3 ) nanoparticles and fluorescent dyes for enhanced contrast magnetic resonance and optical imaging and magnetic-induced cancer therapy. Furthermore, the surface of these prototype nanoclinics is functionalized with a biotargeting group, luteinizing hormone-releasing hormone (LH−RH). In the work reported here, the LH−RH targets receptor-specific cancer cells for utilization in imaging and investigation of biological effects. The structure and function of these nanoclinics have been characterized using electron and X-ray diffractions, transmission electron microscopy, atomic force and scanning electron microscopy and two-photon laser scanning microscopy. Targeting of the receptor-specific cells has been demonstrated, along with the demonstration of a new mechanism of selective destruction of cancer cells, in a dc magnetic field, using these magnetic nanoclinics.
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Cites
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Bilayer Surfactant Stabilized Magnetic Fluids: Synthesis and Interactions at Interfaces
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Clark, H. A., Kopelman, R., Tjalkens, R., & Philbert, M. A. (1999) · Analytical Chemistry · doi:10.1021/ac990630n · Cited by 321
Sonochemical Synthesis of Functionalized Amorphous Iron Oxide Nanoparticles
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Antitumor Immunity Induction by Intracellular Hyperthermia Using Magnetite Cationic Liposomes
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Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
Motornov, M., Roiter, Y., Tokarev, I., & Minko, S. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.10.004 · Cited by 773
Small particles, big impacts: A review of the diverse applications of nanofluids
Taylor, R., Coulombe, S., Otanicar, T., Phelan, P., Gunawan, A., Lv, W., Rosengarten, G., Prasher, R., & Tyagi, H. (2013) · Journal of Applied Physics · doi:10.1063/1.4754271 · Cited by 759
Nanomaterials and singlet oxygen photosensitizers: potential applications in photodynamic therapy
Wang, S., Gao, R., Zhou, F., & Selke, M. (2004) · Journal of Materials Chemistry · doi:10.1039/b311429e · Cited by 384
Magnetite Nanocrystals: Nonaqueous Synthesis, Characterization, and Solubility
Pinna, N., Grancharov, S., Beato, P., Bonville, P., Antonietti, M., & Niederberger, M. (2005) · Chemistry of Materials · doi:10.1021/cm050060+ · Cited by 355
Metadata
- Authors
- Levy, L., Sahoo, Y., Kim, K.-S., Bergey, E. J., & Prasad, P. N.
- Venue
- Chemistry of Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-08-09
- Volume
- 14
- Issue
- 9
- Pages
- 3715-3721
- ISSN
- 0897-4756 (ISSN-L)
- 1520-5002
- OpenAlex
- W2050210241
- Cited by
- 320
- References
- 9
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- closed
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