The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Advances in Copper Complexes as Anticancer Agents
Abstract
Copper is a transition metal that can exist in oxidized (Cu(II)) and reduced (Cu(I)) states. This allows it to participate in redox and catalytic chemistry, making it a suitable cofactor for a diverse range of enzymes and molecules. Copper complexes have been investigated for their therapeutic or diagnostic potential showing effectiveness in cancer treatment due to their cytotoxic action on tumour cells. In this review, the most remarkable achievements in the design and development of copper(I, II) complexes as antitumor agents are discussed. Special emphasis has been focused on the identification of structure-activity relationships for the different classes of complexes. Up to now, despite the enormous efforts in synthesizing different classes of copper complexes, very few data concerning the molecular basis of the mechanisms underlying their antitumor activity are available. The current overview, collecting the most significant strategies adopted in the last four years to design promising anticancer copper(I,II) compounds, aims to provide a useful reference for researchers working in this field.
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Cites
Metals, Toxicity and Oxidative Stress
Valko, M., Morris, H., & Cronin, M. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867053764635 · Cited by 5,018
Cellular processing of platinum anticancer drugs
Wang, D., & Lippard, S. J. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1691 · Cited by 3,801
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Metal Drugs and the Anticancer Immune Response
Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355
Metallodrugs in cancer nanomedicine
Peña, Q., Wang, A., Zaremba, O., Shi, Y., Scheeren, H. W., Metselaar, J. M., Kiessling, F., Pallares, R. M., Wuttke, S., & Lammers, T. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00468a · Cited by 259
Small molecules regulating reactive oxygen species homeostasis for cancer therapy
Zhang, J., Duan, D., Song, Z., Liu, T., Hou, Y., & Fang, J. (2021) · Medicinal Research Reviews · doi:10.1002/med.21734 · Cited by 184
Lu, Y., Pan, Q., Gao, W., Pu, Y., Luo, K., He, B., & Gu, Z. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2021.121335 · Cited by 149
Metadata
- Authors
- Santini, C., Pellei, M., Gandin, V., Porchia, M., Tisato, F., & Marzano, C.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-10-08
- Volume
- 114
- Issue
- 1
- Pages
- 815-862
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W1984883623
- Cited by
- 1,790
- References
- 2
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Santini, C., Pellei, M., Gandin, V., Porchia, M., Tisato, F., & Marzano, C. (2014). Advances in Copper Complexes as Anticancer Agents. Chemical Reviews. https://doi.org/10.1021/cr400135x
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