Small molecule modulators of protein-protein interactions: selected case studies

Cites (525)

Items 201–400 of 525

1. The Microtubule Stabilizing Agent Laulimalide Does Not Bind in the Taxoid Site, Kills Cells Resistant to Paclitaxel and Epothilones, and May Not Require Its Epoxide Moiety for Activity
   Donald E. Pryor, Aurora O’Brate, Geoffrey M. Bilcer, José Fernando Díaz, Yuefang Wang, Yong Wang, Mikio Kabaki, M. Katherine Jung, José M. Andreu, Arun Kumar Ghosh et al. · 2002 · Biochemistry
2. Regulation of microtubule stability and mitotic progression by survivin.
   Alessandra Giodini, Marko J. Kallio, Nathan R. Wall · 2002 · PubMed
3. Chemistry and biology of resorcylic acid lactones
   Nicolas Winssinger, Sofía Barluenga · 2006 · Chemical Communications
4. Structure of a 14-3-3 Coordinated Hexamer of the Plant Plasma Membrane H+-ATPase by Combining X-Ray Crystallography and Electron Cryomicroscopy
   Ottmann, Christian, Marco, Sergio, Jaspert, Nina, Marcon, Caroline, Schauer, Nicolas, Weyand, Michael, Vandermeeren, Caroline, Duby, Geoffrey, Boutry, Marc, Wittinghofer, Alfred et al. · 2007 · Molecular Cell
5. NMR Structure and Mutagenesis of the Third Bir Domain of the Inhibitor of Apoptosis Protein XIAP
   Chaohong C. Sun, Mengli Cai, Robert P. Meadows, Nan Xu, Angelo H. Gunasekera, Julia E. Herrmann, Joe C. Wu, Stephen W. Fesik · 2000 · Journal of Biological Chemistry
6. Development of a Potent Bcl-x L Antagonist Based on α-Helix Mimicry
   Olaf Kutzki, Hyung Soon Park, Justin T. Ernst, Brendan P. Orner, Hang Hubert Yin, Andrew D. Hamilton · 2002 · Journal of the American Chemical Society
7. Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)
   Flygare, John A., Beresini, Maureen, Budha, Nageshwar, Chan, Helen, Chan, Iris T., Cheeti, Sravanthi, Cohen, Frederick, Deshayes, Kurt, Doerner, Karl, Eckhardt, S. Gail et al. · 2012 · Journal of Medicinal Chemistry
8. Molecular characterization of the hdm2-p53 interaction 1 1Edited by J. Karn
   Angelika Böttger, Volker Böttger, Carlos Garcı́a-Echeverrı́a, Patrick Chêne, Heinz Kurt Hochkeppel, Wayne R. Sampson, Kiah How Ang, Stephanie F. Howard, Steven M. Picksley, David Philip Lane · 1997 · Journal of Molecular Biology
9. The conserved N‐terminal BH4 domain of Bcl‐2 homologues is essential for inhibition of apoptosis and interaction with CED‐4
   David C.S. Huang, Jerry M. Adams, Suzanne Cory · 1998 · The EMBO Journal
10. Microtubule dynamics as a target in oncology
    April L. Risinger, Francis Joseph Giles, Susan L. Mooberry · 2008 · Cancer Treatment Reviews
11. Caspase-8 Activation and Bid Cleavage Contribute to MCF7 Cellular Execution in a Caspase-3-dependent Manner during Staurosporine-mediated Apoptosis
    Damu Tang, Jill M. Lahti, Vincent J. Kidd · 2000 · Journal of Biological Chemistry
12. Discovery of Potent Antagonists of the Interaction between Human Double Minute 2 and Tumor Suppressor p53
    Carlos Garcı́a-Echeverrı́a, Patrick Chêne, Marcel J. J. Blommers, Pascal Furet · 2000 · Journal of Medicinal Chemistry
13. Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine
    Robert J. Toso, Mary Ann Jordan, K Farrell, Brian Matsumoto, Leslie Wilson · 1993 · Biochemistry
14. Novobiocin: Redesigning a DNA Gyrase Inhibitor for Selective Inhibition of Hsp90
    Joseph A. Burlison, Len Neckers, Andrew B Smith, Anthony Maxwell, Brian S. J. Blagg · 2006 · Journal of the American Chemical Society
15. Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26
    Yaara Ofir-Rosenfeld, Kristy Boggs, Dan Michael, Michael B. Kastan, Moshe Oren · 2008 · Molecular Cell
16. Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay
    Han‐Zhong Zhang, Shailaja Kasibhatla, Yan Wang · 2003 · Bioorganic & Medicinal Chemistry
17. Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.
    Steven M. Picksley, B Vojtĕsek, Alison Sparks, David Philip Lane · 1994 · PubMed
18. Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins
    Dayong Zhai, Can Jin, Arnold C. Satterthwait, John C. Reed · 2006 · Cell Death and Differentiation
19. Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology
    Eric N. Shiozaki, Yigong Shi · 2004 · Trends in Biochemical Sciences
20. PROPERTIES OF THE PROTEIN SUBUNIT OF CENTRAL-PAIR AND OUTER-DOUBLET MICROTUBULES OF SEA URCHIN FLAGELLA
    Michael L. Shelanski, Edwin William Taylor · 1968 · The Journal of Cell Biology
21. Interactive exploration of chemical space with Scaffold Hunter
    Stefan Wetzel, Karsten Klein, Steffen Renner, Daniel Rauh, Tudor Ionel Oprea, Petra Mutzel, Herbert Waldmann · 2009 · Nature Chemical Biology
22. Clinical Development of 17-Allylamino, 17-Demethoxygeldanamycin
    Edward A. Sausville, Joseph E. Tomaszewski, Percy S. Ivy · 2003 · Current Cancer Drug Targets
23. A Molecular Tweezer for Lysine and Arginine
    Michael Fokkens, Thomas H. Schrader, Frank‐Gerrit Klärner · 2005 · Journal of the American Chemical Society
24. Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (?)-epigallocatechin-3-gallate
    Yu‐Chih Liang, Shoei‐Yn Lin‐Shiau, Chieh-Fu Chen, Jen‐Kun Lin · 1999 · Journal of Cellular Biochemistry
25. Quantitation of chemopreventive synergism between (-)-epigallocatechin- 3-gallate and curcumin in normal, premalignant and malignant human oral epithelial cells
    Avi Khafif · 1998 · Carcinogenesis
26. Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N -acetyltransferase mediated by phosphoserine-205
    Surajit Ganguly, Joan L. Weller, Anthony Ho, Philippe Chemineau, Benoît Malpaux, David C. Klein · 2005 · Proceedings of the National Academy of Sciences
27. Cryptophycin: a new antimicrotubule agent active against drug-resistant cells.
    C.D. Smith, Xiuguo Zhang, Susan L. Mooberry, Gregory M. L. Patterson, Richard E. Moore · 1994 · PubMed
28. Microtubule dynamics: taking aim at a moving target
    Leslie Wilson, Mary Ann Jordan · 1995 · Chemistry & Biology
29. Expression and Genetic Analysis of XIAP-Associated Factor 1 (XAF1) in Cancer Cell Lines
    Wai Gin Fong, Peter Liston, Evica Rajcan‐Separovic, Martine St. Jean, Constance G. Craig, Robert G. Korneluk · 2000 · Genomics
30. Design, Synthesis, and Characterization of a Potent, Nonpeptide, Cell-Permeable, Bivalent Smac Mimetic That Concurrently Targets Both the BIR2 and BIR3 Domains in XIAP
    Haiying Sun, Zaneta Nikolovska‐Coleska, Jianfeng Lü, Jennifer L. Meagher, Chao‐Yie Yang, Su Qiu, York A. Tomita, Yumi Ueda, Sheng Jiang, Krzysztof Krajewski et al. · 2007 · Journal of the American Chemical Society
31. A Nucleotide-dependent Molecular Switch Controls ATP Binding at the C-terminal Domain of Hsp90
    Csaba Sőti, Áttila Rácz, Péter Csermely · 2002 · Journal of Biological Chemistry
32. Microtubule Dynamics and Kinetochore Function in Mitosis
    Timothy John Mitchison · 1988 · Annual Review of Cell Biology
33. Targeting cell division: Small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality
    Danielle Nina Margalit, Laura Romberg, Rebecca B. Mets-Halgrimson, Alan M. Hebert, Timothy John Mitchison, Marc W. Kirschner, Debabrata RayChaudhuri · 2004 · Proceedings of the National Academy of Sciences
34. Grand Challenge Commentary: Accessing new chemical space for 'undruggable' targets
    Sivaraman Dandapani, Lisa A. Marcaurelle · 2010 · Nature Chemical Biology
35. Dynamic control of signaling by modular adaptor proteins
    Tony J. Pawson · 2007 · Current Opinion in Cell Biology
36. Total synthesis of prodigiosin, prodigiosene, and desmethoxyprodigiosin: Diels-Alder reactions of heterocyclic azadienes and development of an effective palladium(II)-promoted 2,2'-bipyrrole coupling procedure
    Dale L. Boger, Mona Patel · 1988 · The Journal of Organic Chemistry
37. X-Linked Inhibitor of Apoptosis Protein (XIAP) Is a Nonredundant Modulator of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)- Mediated Apoptosis in Human Cancer Cells
    Cummins, Jordan M., Kohli, Manu, Rago, Carlo, Kinzler, Kenneth W., Vogelstein, Bert, Bunz, Fred · 2004 · Cancer Research
38. Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives
    Rodney C. Schnur, Michael L. Corman, Randall J. Gallaschun, Beth A. Cooper, Michael F. Dee, Jonathan L. Doty, M. L. Muzzi, James D. Moyer, C DiOrio · 1995 · Journal of Medicinal Chemistry
39. Molecular tweezers modulate 14-3-3 protein–protein interactions
    David Bier, Rolf Rose, Kenny Bravo‐Rodriguez, Maria Bartel, Juan Manuel Ramírez‐Anguita, Som Dutt, Constanze Wilch, Frank‐Gerrit Klärner, Elsa Sánchez‐García, Thomas H. Schrader et al. · 2013 · Nature Chemistry
40. MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins
    Eric Kobet, Xiaoya Zeng, Yong Zhu, David Keller, Hua Lu · 2000 · Proceedings of the National Academy of Sciences
41. Antineoplastic agents. 219. Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp
    George R. Pettit, Cherry L. Herald, Michael R. Boyd, John E. Leet, Claude Dufresne, Dennis L. Doubek, Jean M. Schmidt, Ronald L. Cerny, John N. A. Hooper, Klaus C. Rutzler · 1991 · Journal of Medicinal Chemistry
42. Amino-acid Composition of “Tubulin” constituting Microtubules of Sperm Flagella
    Hideo Mohri · 1968 · Nature
43. Natural products which interact with tubulin in the vinca domain: Maytansine, rhizoxin, phomopsin a, dolastatins 10 and 15 and halichondrin B
    Ernest Hamel · 1992 · Pharmacology & Therapeutics
44. Human Ovarian Cancer and Cisplatin Resistance: Possible Role of Inhibitor of Apoptosis Proteins1
    Julang Li, Qiang Feng, Jong‐Min Kim et al. · 2001 · Endocrinology
45. Structure determination, conformational analysis, chemical stability studies, and antitumor evaluation of the cryptophycins. isolation of 18 new analogs from nostoc sp. strain GSV 224
    Golakoti, Trimurtulu, Ogino, Junichi, Heltzel, Carl E., Le Husebo, Trang, Jensen, Craig M., Larsen, Linda K., Patterson, Gregory M. L., Moore, Richard E., Mooberry, Susan L., Corbett, Thomas H. et al. · 1995 · Journal of the American Chemical Society
46. 14-3-3 α and δ Are the Phosphorylated Forms of Raf-activating 14-3-3 β and ζ
    Alastair Aitken, Steven A. Howell, David T. Jones · 1995 · Journal of Biological Chemistry
47. The Synthesis of Prodigiosin
    Henry Rapoport, Kenneth G. Holden · 1962 · Journal of the American Chemical Society
48. Fusicoccin: a New Wilting Toxin produced by Fusicoccum amygdali Del.
    ALESSANDRO BALLIO, Ernst Boris Chain, Piero De Leo, B. F. ERLANGER, M. MAURI, A. TONOLO · 1964 · Nature
49. Microtubule Active Agents: Beyond the Taxane Frontier
    Patrick Glyn Morris, Monica Nancy Fornier · 2008 · Clinical Cancer Research
50. p53 regulation by post-translational modification and nuclear retention in response to diverse stresses
    Gretchen S. Jimenez, Shireen H Khan, Jayne M. Stommel, Geoffrey M. Wahl · 1999 · Oncogene
51. Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia
    Hetz, Claudio, Vitte, Pierre-Alain, Bombrun, Agnes, Rostovtseva, Tatiana K., Montessuit, Sylvie, Hiver, Agnes, Schwarz, Matthias K., Church, Dennis J., Korsmeyer, Stanley J., Martinou, Jean-Claude et al. · 2005 · Journal of Biological Chemistry
52. Protein–protein interactions and cancer: small molecules going in for the kill
    Michelle R. Arkin · 2005 · Current Opinion in Chemical Biology
53. Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs
    Kerry Zobel, Lan Wang, Eugene E. Varfolomeev, Matthew C. Franklin, Linda O. Elliott, Heidi J.A. Wallweber, David C. Okawa, John A. Flygare, Domagoj Vucic, Wayne J. Fairbrother et al. · 2006 · ACS Chemical Biology
54. Hsp90 Inhibitors Identified from a Library of Novobiocin Analogues
    Xiao Ming Yu, Gang Shen, Len Neckers, Helen M. Blake, Jeff M. Holzbeierlein, Benjamin B. Cronk, Brian S. J. Blagg · 2005 · Journal of the American Chemical Society
55. Current strategies for diversity-oriented synthesis
    Sivaraman Dandapani, Lisa A. Marcaurelle · 2010 · Current Opinion in Chemical Biology
56. Advances in Solution- and Solid-Phase Synthesis toward the Generation of Natural Product-like Libraries
    Jyoti Prokash Nandy, Michael A. Prakesch, Shahriar Khadem · 2009 · Chemical Reviews
57. Isolation and Structure Elucidation of Chlorofusin, a Novel p53-MDM2 Antagonist from a Fusarium sp.
    Sara J. Duncan, Sabine Grüschow, Dudley Howard Williams, Carole McNicholas, Ravinder Purewal, Michal Hájek, Martin Gerlitz, Steven Martin, Stephen K. Wrigley, Michael Moore · 2001 · Journal of the American Chemical Society
58. Solution‐Phase Combinatorial Libraries: Modulating Cellular Signaling by Targeting Protein–Protein or Protein–DNA Interactions
    Dale L. Boger, Joel Desharnais, Kevin Capps · 2003 · Angewandte Chemie International Edition
59. Kinetic suppression of microtubule dynamic instability by griseofulvin: Implications for its possible use in the treatment of cancer
    Dulal Panda, Krishnan Rathinasamy, Manas Kumar Santra, Leslie Wilson · 2005 · Proceedings of the National Academy of Sciences
60. 1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR
    Daniel J. Parks, Louis V. LaFrance, Raul R. Calvo, Karen L. Milkiewicz, Varsha Gupta, Jennifer Lattanze, Kannan Ramachandren, Theodore E. Carver, Eugene C. Petrella, Maxwell D. Cummings et al. · 2004 · Bioorganic & Medicinal Chemistry Letters
61. Direct and selective small-molecule activation of proapoptotic BAX
    Evripidis Gavathiotis, Denis E. Reyna, Joseph A. Bellairs, Elizaveta S. Leshchiner, Loren D. Walensky · 2012 · Nature Chemical Biology
62. A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
    Erinna F. Lee, Peter E. Czabotar, Mark F. van Delft, Ewa Malgorzata Michalak, Michelle J. Boyle, Simon N. Willis, Hamsa Puthalakath, Philippe Bouillet, Peter M. Colman, David C.S. Huang et al. · 2008 · The Journal of Cell Biology
63. Total Synthesis of Cryptophycins. Revision of the Structures of Cryptophycins A and C
    Russell Allan Barrow, Thomas K. Hemscheidt, Jian Liang, Seunguk Paik, Richard E. Moore, Marcus A. Tius · 1995 · Journal of the American Chemical Society
64. The Microtubule Plus-End Proteins EB1 and Dynactin Have Differential Effects on Microtubule Polymerization
    Lee A. Ligon, Spencer S. Shelly, Mariko K. Tokito, Erika L.F. Holzbaur · 2003 · Molecular Biology of the Cell
65. The Olefin Metathesis Approach to Epothilone A and Its Analogues
    Kyriacos Costa Nicolaou, Yan He, Dionisios Vourloumis · 1997 · Journal of the American Chemical Society
66. The fusicoccin receptor of plants is a member of the 14‐3‐3 superfamily of eukaryotic regulatory proteins
    Claudia Oecking, Christoph Eckerskorn, Elmar W. Weiler · 1994 · FEBS Letters
67. Localization of the Vinblastine-binding Site on β-Tubulin
    Sadananda S. Rai, J. Wolff · 1996 · Journal of Biological Chemistry
68. Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction
    Yosup Rew, Daqing Sun, Felix González-López de Turiso, Michael D. Bartberger, Hilary P. Beck, Jude R. Canon, Ada Chen, David T. Chow, Jeffrey Deignan, Brian M. Fox et al. · 2012 · Journal of Medicinal Chemistry
69. Synthesis and structure-activity relations of bestatin analogs, inhibitors of aminopeptidase B
    RINZO NISHIZAWA, Tetsushi Saino, TOMOHISA TAKITA · 1977 · Journal of Medicinal Chemistry
70. Macrocyclic ketone analogues of halichondrin B
    Wanjun Zheng, Boris M. Seletsky, Monica H. Palme et al. · 2004 · Bioorganic & Medicinal Chemistry Letters
71. Network medicine
    Tony J. Pawson, Rune Linding · 2008 · FEBS Letters
72. Reprieval from execution: the molecular basis of caspase inhibition
    Henning R. Stennicke, Ciara Ryan, Guy S. Salvesen · 2002 · Trends in Biochemical Sciences
73. Discovery and development of heat shock protein 90 inhibitors
    Tony Taldone, Weilin Sun, Gabriela Chiosis · 2008 · Bioorganic & Medicinal Chemistry
74. Modulation of Chaperone Function and Cochaperone Interaction by Novobiocin in the C-terminal Domain of Hsp90
    Rudi K. Allan, Danny Mok, Bryan K. Ward, Thomas Ratajczak · 2006 · Journal of Biological Chemistry
75. Kinetic studies of RNA–protein interactions using surface plasmon resonance
    Phinikoula S. Katsamba · 2002 · Methods
76. Structure-Based Design of Potent, Conformationally Constrained Smac Mimetics
    Haiying Sun, Zaneta Nikolovska‐Coleska, Chao‐Yie Yang, Liang Xu, Meilan Liu, York A. Tomita, Hongguang Pan, Yoshiko Yoshioka, Krzysztof Krajewski, Peter P. Roller et al. · 2004 · Journal of the American Chemical Society
77. Identification of Chelerythrine as an Inhibitor of BclXL Function
    Shing Leng Chan, Mei Lee, Kuan Onn Tan, Lay‐Kien Yang, Alex S. Y. Lee, Horst Flotow, Nai Yang Fu, Mark S. Butler, Djaja Doel Soejarto, Antony David Buss et al. · 2003 · Journal of Biological Chemistry
78. Ixabepilone (Epothilone B Analogue BMS-247550) Is Active in Chemotherapy-Naive Patients With Hormone-Refractory Prostate Cancer: A Southwest Oncology Group Trial S0111
    Maha Hussain, Catherine M. Tangen, Primo N. Lara, Ulka N. Vaishampayan, Daniel Peter Petrylak, Alexander Dimitrios Colevas, Wael Sakr, Elward David Crawford · 2005 · Journal of Clinical Oncology
79. Targeting protein–protein interactions for cancer therapy
    David C. Fry, Lyubomir T. Vassilev · 2005 · Journal of Molecular Medicine
80. Chirospecific syntheses of (+)- and (-)-anatoxin a
    John S. Petersen, Gregor Fels, Henry Rapoport · 1984 · Journal of the American Chemical Society
81. Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac
    Huang, Yihua, Rich, Rebecca L., Myszka, David G., Wu, Hao · 2003 · Journal of Biological Chemistry
82. Synthesis and biological activities of novel 17-aminogeldanamycin derivatives
    Zong‐Qiang Tian, Yaoquan Liu, Dan Zhang, Zhan Wang, Steven D. Dong, Christopher W. Carreras, Yiqing Zhou, Giulio Rastelli, Daniel V. Santi, David C. Myles · 2004 · Bioorganic & Medicinal Chemistry
83. Molecular Dissection of the Microtubule Depolymerizing Activity of Mitotic Centromere-associated Kinesin
    Todd Maney, Michael Wagenbach, Linda G. Wordeman · 2001 · Journal of Biological Chemistry
84. Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid
    Anna Kruczynski, Jean-Marc M. Barret, Chantal Etiévant · 1998 · Biochemical Pharmacology
85. In Vivo Photocrosslinking with Unnatural Amino Acid Mutagenesis
    Jason W. Chin, Peter G. Schultz · 2002 · ChemBioChem
86. Discovery and Optimization of Chromenotriazolopyrimidines as Potent Inhibitors of the Mouse Double Minute 2−Tumor Protein 53 Protein−Protein Interaction
    John G. Allen, Matthew P. Bourbeau, G. Erich Wohlhieter, Michael D. Bartberger, Klaus Michelsen, Randall W. Hungate, Robert C. Gadwood, Rick D. Gaston, Bruce Evans, Larry W. Mann et al. · 2009 · Journal of Medicinal Chemistry
87. The Halichondrins and E7389
    Katrina L. Jackson, James A. Henderson, Andrew J. Phillips · 2009 · Chemical Reviews
88. Molecular Clip and Tweezer Introduce New Mechanisms of Enzyme Inhibition
    Peter Talbiersky, Frank Bastkowski, Frank‐Gerrit Klärner · 2008 · Journal of the American Chemical Society
89. Pochonins A−F, New Antiviral and Antiparasitic Resorcylic Acid Lactones from Pochonia chlamydosporia var. catenulata
    Veronika Hellwig, Anke Mayer‐Bartschmid, Hartwig Müller · 2003 · Journal of Natural Products
90. A Small-Molecule Inhibitor of Bcl-XL Potentiates the Activity of Cytotoxic Drugs In vitro and In vivo
    Alex R. Shoemaker, Anatol Oleksijew, Joy L. Bauch, Barbara Belli, Tony Borre, Milan Bruncko, Thomas Deckwirth, David J. Frost, Ken Jarvis, Mary K. Joseph et al. · 2006 · Cancer Research
91. A Novel Application of a Pd(0)-Catalyzed Nucleophilic Substitution Reaction to the Regio- and Stereoselective Synthesis of Lactam Analogues of the Epothilone Natural Products
    R. M. Borzilleri, Xiaoping Zheng, Robert J. Schmidt et al. · 2000 · Journal of the American Chemical Society
92. Managing taxane toxicities
    Maurie M. Markman · 2003 · Supportive Care in Cancer
93. Concise Asymmetric Syntheses of Radicicol and Monocillin I
    R. M. Garbaccio, Shawn J. Stachel, Daniel K. Baeschlin · 2001 · Journal of the American Chemical Society
94. Exploring New Chemical Space by Stereocontrolled Diversity-Oriented Synthesis
    P. Arya, Reni Joseph, Zhonghong Gan, Bojana Rakić · 2005 · Chemistry & Biology
95. Bioactivity-guided mapping and navigation of chemical space
    Steffen Renner, Willem A. L. van Otterlo, Marta Domínguez, Sabine Möcklinghoff, Bettina Hofmann, Stefan Wetzel, Ansgar Schuffenhauer, Peter Ertl, Tudor Ionel Oprea, Dieter Steinhilber et al. · 2009 · Nature Chemical Biology
96. Identification and partial characterization of new antigens from simian virus 40-transformed mouse cells
    Chung-Ming Chang, Daniel T. Simmons, Miguel Martı́n · 1979 · Journal of Virology
97. Organic synthesis toward small-molecule probes and drugs
    Stuart L. Schreiber · 2011 · Proceedings of the National Academy of Sciences
98. Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo
    Michael D. Wendt, Shen Wang, Aaron R. Kunzer, William J. McClellan, Milan Bruncko, Thorsten K. Oost, Hong Ding, Mary K. Joseph, Haichao Zhang, Paul M. Nimmer et al. · 2006 · Journal of Medicinal Chemistry
99. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP
    Domagoj Vucic, Matthew C. Franklin, Heidi J.A. Wallweber, Kanad DAS, Brendan P. Eckelman, Hwain Shin, Linda O. Elliott, Saloumeh Kadkhodayan, Kurt Deshayes, Guy S. Salvesen et al. · 2004 · Biochemical Journal
100. Bax Inhibitor-1 Regulates Endoplasmic Reticulum Stress-associated Reactive Oxygen Species and Heme Oxygenase-1 Expression
     Geum‐Hwa Lee, Hyun-Kyung Kim, Soo‐Wan Chae, Do‐Sung Kim, Ki-Chan Ha, Mike Cuddy, Christina L. Kress, John C. Reed, Hyung‐Ryong Kim, Han–Jung Chae · 2007 · Journal of Biological Chemistry
101. Analysis by Surface Plasmon Resonance of the Influence of Valence on the Ligand Binding Affinity and Kinetics of an Anti-carbohydrate Antibody
     C. Roger MacKenzie, Tomoko Hirama, Su-Jun Deng, David R. Bundle, Saran Adhar Narang, Noel Martin Young · 1996 · Journal of Biological Chemistry
102. MDM2-ARF complex regulates p53 sumoylation
     Chen, Lihong, Chen, Jiandong · 2003 · Oncogene
103. The Small Organic Compound HA14-1 Prevents Bcl-2 Interaction with Bax to Sensitize Malignant Glioma Cells to Induction of Cell Death
     Florence Manero, Fabien Gautier, Tristan Gallenne, Nicolas Cauquil, Danielle M. Gree, Pierre‐François Cartron, Olivier Geneste, Rene L. Gree, François M. Vallette, Philippe Paul Juin · 2006 · Cancer Research
104. Protein–protein interfaces: mimics and inhibitors
     Andrea G. Cochran · 2001 · Current Opinion in Chemical Biology
105. KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.
     Shiro Soga, L M Neckers, T W Schulte, Yukimasa Shiotsu, K Akasaka, H Narumi, Tsutomu Agatsuma, Y. IKUINA, Chikara Murakata, T Tamaoki et al. · 1999 · PubMed
106. Structure-Based Design, Synthesis, and Evaluation of Conformationally Constrained Mimetics of the Second Mitochondria-Derived Activator of Caspase That Target the X-Linked Inhibitor of Apoptosis Protein/Caspase-9 Interaction Site
     Haiying Sun, Zaneta Nikolovska‐Coleska, Chao‐Yie Yang, Liang Xu, York A. Tomita, Krzysztof Krajewski, Peter P. Roller, Shaomeng Wang · 2004 · Journal of Medicinal Chemistry
107. Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly
     Ernest Hamel, Billy W. Day, John Holmes Miller, M. Katherine Jung, Peter T. Northcote, Arun Kumar Ghosh, Dennis P. Curran, Mark Cushman, Kyriacos Costa Nicolaou, Ian Paterson et al. · 2006 · Molecular Pharmacology
108. Gambogic Acid, a Natural Product Inhibitor of Hsp90
     Jason Davenport, Jacob R. Manjarrez, Laura B. Peterson, Brian Krumm, Brian S. J. Blagg, Robert L. Matts · 2011 · Journal of Natural Products
109. Phase II Clinical Trial of the Epothilone B Analog, Ixabepilone, in Patients With Non–Small-Cell Lung Cancer Whose Tumors Have Failed First-Line Platinum-Based Chemotherapy
     Johan Vansteenkiste, Primo N. Lara, Thierry Le Chevalier et al. · 2007 · Journal of Clinical Oncology
110. The client protein p53 adopts a molten globule–like state in the presence of Hsp90
     Park, Sung Jean, Borin, Brendan N, Martinez-Yamout, Maria A, Dyson, H Jane · 2011 · Nature Structural & Molecular Biology
111. The Middle Domain of Hsp90 Acts as a Discriminator between Different Types of Client Proteins
     Hawle, Patricija, Siepmann, Martin, Harst, Anja, Siderius, Marco, Reusch, H. Peter, Obermann, Wolfgang M. J. · 2006 · Molecular and Cellular Biology
112. Oncogenic re-wiring of cellular signaling pathways
     Tony J. Pawson, Neil E. Warner · 2007 · Oncogene
113. Synthesis, Proton-Affinity and Anti-Cancer Properties of the Prodigiosin-Group Natural Products
     Richard A. Manderville · 2001 · Anti-Cancer Agents in Medicinal Chemistry
114. Identification and Structure of Small‐Molecule Stabilizers of 14–3–3 Protein–Protein Interactions
     Rolf Rose, Silke Erdmann, Stefanie Bovens, Alexander Wolf, Micheline Rose, Sven Hennig, Herbert Waldmann, Christian Ottmann · 2010 · Angewandte Chemie International Edition
115. Development and Characterization of Nonpeptidic Small Molecule Inhibitors of the XIAP/Caspase-3 Interaction
     Tom Y.-H. Wu, Klaus W Wagner, Badry D. Bursulaya, Peter G. Schultz, Quinn L. Deveraux · 2003 · Chemistry & Biology
116. Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells
     Bing Z. Carter, Marcela Gronda, Zhiliang Wang, Kate Welsh, Clemencia Pinilla, Michael Andreeff, Wendy D. Schober, Adel Nefzi, Gregory R. Pond, Imtiaz A. Mawji et al. · 2005 · Blood
117. Geldanamycin. I. Structure assignment
     KENNETH L. Jr. RINEHART, Kazuya Sasaki, George Slomp · 1970 · Journal of the American Chemical Society
118. Gossypol induces Bax/Bak‐independent activation of apoptosis and cytochrome c release via a conformational change in Bcl‐2
     Xiaobo Lei, Yingyu Chen, Guanhua Du, Wenyu Yu, Xiaohui Wang, Hong Qu, Bin Xia, Hongping He, Jianhua Mao, Wei‐Xing Zong et al. · 2006 · The FASEB Journal
119. A Novel Class of Small Molecule Inhibitors of Hsp90
     Fang Yi, Lynne Regan · 2008 · ACS Chemical Biology
120. A Novel Approach for Characterizing Protein Ligand Complexes: Molecular Basis for Specificity of Small-Molecule Bcl-2 Inhibitors
     Alexey A. Lugovskoy, Alexei Degterev, Amr F. Fahmy, Pei Zhou, John D. Gross, Junying Yuan, Gerhard Wagner · 2002 · Journal of the American Chemical Society
121. Structural Mimicry of Canonical Conformations in Antibody Hypervariable Loops Using Cyclic Peptides Containing a Heterochiral Diproline Template
     Michel Favre, Kerstin Moehle, Luyong Jiang, Bernhard Pfeiffer, John A. Robinson · 1999 · Journal of the American Chemical Society
122. Global approaches to protein–protein interactions
     Gerard Drewes, Tewis Bouwmeester · 2003 · Current Opinion in Cell Biology
123. The Prodigiosins: A New Family of Anticancer Drugs
     Beatriz Montaner, Ricardo Pérez‐Tomás · 2003 · Current Cancer Drug Targets
124. Phase III Trials of Eribulin Mesylate (E7389) in Extensively Pretreated Patients With Locally Recurrent or Metastatic Breast Cancer
     Chris Twelves, Javier Cortés, Linda T. Vahdat · 2010 · Clinical Breast Cancer
125. Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol.
     Ho Jeong Kwon, Minoru Yoshida, Yasuhisa Fukui · 1992 · PubMed
126. Protein–protein interactions in the allosteric regulation of protein kinases
     Patricia Pellicena, John Kuriyan · 2006 · Current Opinion in Structural Biology
127. Antiproliferative mechanism of action of cryptophycin-52: Kinetic stabilization of microtubule dynamics by high-affinity binding to microtubule ends
     Dulal Panda, Keith F. DeLuca, Daniel C. Williams, Mary Ann Jordan, Leslie Wilson · 1998 · Proceedings of the National Academy of Sciences
128. A Semisynthetic Fusicoccane Stabilizes a Protein-Protein Interaction and Enhances the Expression of K+ Channels at the Cell Surface
     Anders, Carolin, Higuchi, Yusuke, Koschinsky, Kristin, Bartel, Maria, Schumacher, Benjamin, Thiel, Philipp, Nitta, Hajime, Preisig-Müller, Regina, Schlichthörl, Günter, Renigunta, Vijay et al. · 2013 · Chemistry & Biology
129. Mechanistic studies of Sansalvamide A-amide: An allosteric modulator of Hsp90
     Vasko, Robert C., Rodriguez, Rodrigo A., Cunningham, Christian N., Ardi, Veronica C., Agard, David A., McAlpine, Shelli R. · 2010 · ACS Medicinal Chemistry Letters
130. Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor
     Zhao, Jing, Du, Yuhong, Horton, John R., Upadhyay, Anup K., Lou, Bin, Bai, Yan, Zhang, Xing, Du, Lupei, Li, Minyong, Wang, Binghe et al. · 2011 · Proceedings of the National Academy of Sciences
131. Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists
     Chudi O. Ndubaku, Eugene E. Varfolomeev, Lan Wang, Kerry Zobel, Kevin Lau, Linda O. Elliott, Brigitte Maurer, Anna V. Fedorova, Jasmin N. Dynek, Michael F. T. Koehler et al. · 2009 · ACS Chemical Biology
132. Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene
     Irena Crnković‐Mertens, Felix Hoppe‐Seyler, Karin Butz · 2003 · Oncogene
133. C-terminal Recognition by 14-3-3 Proteins for Surface Expression of Membrane Receptors
     Brian Coblitz, Sojin Shikano, Meng Wu, Sandra B. Gabelli, Lisa M. Cockrell, Matt Spieker, Yoshiro Hanyu, Haian Fu, L. Mario Amzel, Min Li · 2005 · Journal of Biological Chemistry
134. The Interaction of TOGp with Microtubules and Tubulin
     Cynthia S. Spittle, Sophie Charrasse, Christian Larroque · 2000 · Journal of Biological Chemistry
135. Mechanism of Action of Cryptophycin
     Charles D. Smith, Xinqun Zhang · 1996 · Journal of Biological Chemistry
136. The three-dimensional solution structure and dynamic properties of the human FADD death domain 1 1Edited by A. Fersht
     Helena Berglund, Dionne Olerenshaw, Andrew Sankar, Matthias Federwisch, Neil Q. McDonald, Paul C. Driscoll · 2000 · Journal of Molecular Biology
137. An Approach to Epothilones Based on Olefin Metathesis
     Kyriacos Costa Nicolaou, Yun He, Dionisios Vourloumis · 1996 · Angewandte Chemie International Edition in English
138. Total Synthesis of (−)-Laulimalide
     Paul A. Wender, Sayee G. Hegde, Robert D. Hubbard · 2002 · Journal of the American Chemical Society
139. Sensitization of Cervical Cancer Cells to Cisplatin by Genistein: The Role of NFB and Akt/mTOR Signaling Pathways
     Kazım Şahin, Mehmet Tuzcu, Neşe Başak · 2012 · Journal of Oncology
140. Microarray‐Assisted High‐Throughput Identification of a Cell‐Permeable Small‐Molecule Binder of 14‐3‐3 Proteins
     Hao Wu, Jingyan Ge, Shao Qin Yao · 2010 · Angewandte Chemie International Edition
141. Natural product-like chemical space: search for chemical dissectors of macromolecular interactions
     Ayub Reayi, P. Arya · 2005 · Current Opinion in Chemical Biology
142. Tubulin Assembly, Taxoid Site Binding, and Cellular Effects of the Microtubule-Stabilizing Agent Dictyostatin
     Charitha Madiraju, Michael Edler, Ernest Hamel, Brianne S. Raccor, Raghavan Balachandran, Guangyu Zhu, Kenneth A. Giuliano, Andreas Vogt, Youseung Shin, Jean‐Hugues Fournier et al. · 2005 · Biochemistry
143. Inhibitory effects of tea extracts and (−)-epigallocatechin gallate on DNA synthesis and proliferation of hepatoma and erythroleukemia cells
     Michael Anthony Lea, Qin Xiao, Ankur K. Sadhukhan · 1993 · Cancer Letters
144. The constitution of gambogic acid
     W. David Ollis, M. V. J. RAMSAY, Ian O. Sutherland · 1965 · Tetrahedron
145. A Structural Rationale for Selective Stabilization of Anti-tumor Interactions of 14-3-3 proteins by Cotylenin A
     Ottmann, Christian, Weyand, Michael, Sassa, Takeshi, Inoue, Takatsugu, Kato, Nobuo, Wittinghofer, Alfred, Oecking, Claudia · 2009 · Journal of Molecular Biology
146. Radicicol Leads to Selective Depletion of Raf Kinase and Disrupts K-Ras-activated Aberrant Signaling Pathway
     Shiro Soga, Takako Kozawa, Hiroaki Narumi, Shiro Akinaga, Kenji Irie, Kunihiro Matsumoto, Sreenath V. Sharma, Hirofumi Nakano, Tamio Mizukami, Mitsunobu Hara · 1998 · Journal of Biological Chemistry
147. Enantioselective Synthesis of Epigallocatechin-3-gallate (EGCG), the Active Polyphenol Component from Green Tea
     Lian‐Hai Li, Tak Hang Chan · 2001 · Organic Letters
148. Hsp90 as a Target for Drug Development
     Subhabrata Chaudhury, Timothy R. Welch, Brian S. J. Blagg · 2006 · ChemMedChem
149. Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer
     Shangary, Sanjeev, Ding, Ke, Qiu, Su, Nikolovska-Coleska, Zaneta, Bauer, Joshua A., Liu, Meilan, Wang, Guoping, Lu, Yipin, McEachern, Donna, Bernard, Denzil et al. · 2008 · Molecular Cancer Therapeutics
150. Cascades of Mammalian Caspase Activation in the YeastSaccharomyces cerevisiae
     Jason Kang, Michael D. Schaber, Srinivasa Murty Srinivasula, Emad S. Alnemri, Gerald Litwack, David J. Hall, Mary‐Ann Bjornsti · 1999 · Journal of Biological Chemistry
151. Improved Procedure for the Solution Phase Preparation of 1,4-Benzodiazepine-2,5-dione Libraries via Armstrong's Convertible Isonitrile and the Ugi Reaction
     Christopher Hulme, John Peng, Sheng-Yuh Tang · 1998 · The Journal of Organic Chemistry
152. Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-XL
     Helena L.A. Vieira, Patricia Boya, Isabelle Cohen, Chahrazed El Hamel, D. Haouzi, Sabine Druillennec, Anne-Sophie Belzacq, Catherine Brenner, Bernard Pierre Roques, Guido Kroemer · 2002 · Oncogene
153. Peloruside A Synergizes with Other Microtubule Stabilizing Agents in Cultured Cancer Cell Lines
     Anja Wilmes, Kelly Bargh, Colleen Kelly · 2007 · Molecular Pharmaceutics
154. Breast Cancer Cells Can Evade Apoptosis-Mediated Selective Killing by a Novel Small Molecule Inhibitor of Bcl-2
     Pedro J. Real, Yeyu Cao, Renxiao Wang, Zaneta Nikolovska‐Coleska, Jaime Sanz‐Ortiz, Shaomeng Wang, José L. Fernández-Luna · 2004 · Cancer Research
155. Hexylitaconic acid: A new inhibitor of p53–HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp.
     Sachiko Tsukamoto, Takushi Yoshida, Hidetaka Hosono, Tomihisa Ohta, Hideyoshi Yokosawa · 2005 · Bioorganic & Medicinal Chemistry Letters
156. Dissecting Fas signaling with an altered-specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation
     Howard Y. Chang, Xiaolu Yang, David Baltimore · 1999 · Proceedings of the National Academy of Sciences
157. Biological properties of Vincaleukoblastine, an alkaloid in Vinca rosea Linn, with reference to its antitumor action.
     James H. Cutts, C. T. Beer, ROBERT L. NOBLE · 1960 · PubMed
158. Rational Design of Diflunisal Analogues with Reduced Affinity for Human Serum Albumin
     Hongyuan Mao, Philip J. Hajduk, Richard Craig, Randy Bell, Tony Borre, Stephen W. Fesik · 2001 · Journal of the American Chemical Society
159. Laulimalide and Paclitaxel: A Comparison of Their Effects on Tubulin Assembly and Their Synergistic Action When Present Simultaneously
     Eric J. Gapud, Ruoli Bai, Arun Kumar Ghosh, Ernest Hamel · 2004 · Molecular Pharmacology
160. Synthesis and Biological Evaluation of a New Class of Geldanamycin Derivatives as Potent Inhibitors of Hsp90
     Jean‐Yves Le Brazidec, Adeela Kamal, David J. Busch, Lia Thao, Lin Zhang, Gregg A. Timony, Roy Grecko, Katy Trent, Rachel E. Lough, Tim Salazar et al. · 2004 · Journal of Medicinal Chemistry
161. The constitution of monorden, an antibiotic with tranquilising action
     Frank McCapra, A. Ian Scott, P. Delmotte, J. Delmotte-Plaquée, Norman S. Bhacca · 1964 · Tetrahedron Letters
162. Synthesis of a 2,3‘;6‘,3‘ ‘-Terpyridine Scaffold as an α-Helix Mimetic
     Jessica Michaud Davis, Anh Truong, Andrew D. Hamilton · 2005 · Organic Letters
163. Chrysanthemic acid. V. Thermal and photo [3,3]sigmatropic rearrangements in the cis-2,2-dimethyl-3-isobutenylcyclopropyl isocyanate-3,6-dihydro-3,3,6,6-tetramethyl-2H-azepin-2-one system
     Tadashi Sasaki, Shoji Eguchi, Masatomi Ohno · 1970 · Journal of the American Chemical Society
164. Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives
     Robert P. Sellers, Leslie D. Alexander, Victoria A. Johnson, Chun-Chieh Lin, Jeremiah H. Savage, Ricardo Corral, Jason A. Moss, Tim S. Slugocki, Erinprit K. Singh, Melinda R. Davis et al. · 2010 · Bioorganic & Medicinal Chemistry
165. Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics
     Carlos María Galmarini, Kathy Kamath, A Vanier-Viornery · 2003 · British Journal of Cancer
166. Total Synthesis of (+)-Geldanamycin and (−)-o-Quinogeldanamycin: Asymmetric Glycolate Aldol Reactions and Biological Evaluation
     Merritt B. Andrus, Erik L. Meredith, Erik J. Hicken · 2003 · The Journal of Organic Chemistry
167. 3-(5-chloro-2,4-dihydroxyphenyl)-Pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone
     Paul A. Brough, Xavier Barril, Mandy Beswick · 2005 · Bioorganic & Medicinal Chemistry Letters
168. Dynamic Interaction of Hsp90 with Its Client Protein p53
     Sung Jean Park, Milka Kostić, H. Jane Dyson · 2011 · Journal of Molecular Biology
169. Biophysical Characterization of Recombinant Human Bcl-2 and Its Interactions with an Inhibitory Ligand, Antimycin A
     Kristine M. Kim, Chris D. Giedt, Gorka Basáñez · 2001 · Biochemistry
170. Monomer Arrangement in HSP90 Dimer as Determined by Decoration with N and C-Terminal Region Specific Antibodies
     Mikako Maruya, Masazumi Sameshima, Takayuki Nemoto, Ichiro Yahara · 1999 · Journal of Molecular Biology
171. New Syntheses of E7389 C14−C35 and Halichondrin C14−C38 Building Blocks: Double-Inversion Approach
     Dae‐Shik Kim, Cheng‐Guo Dong, Joseph T. Kim · 2009 · Journal of the American Chemical Society
172. Structure-based discovery of a new class of Hsp90 inhibitors
     Xavier Barril, Paul A. Brough, Martin Drysdale · 2005 · Bioorganic & Medicinal Chemistry Letters
173. Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein–protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis
     Valentina Corradi, Manuela Mancini, Fabrizio Manetti, Sara Petta, Maria Alessandra Santucci, Maurizio Botta · 2010 · Bioorganic & Medicinal Chemistry Letters
174. In vitro and in vivo anticancer activities of synthetic (-)-laulimalide, a marine natural product microtubule stabilizing agent.
     Junke Liu, Murray J. Towle, Hongsheng Cheng, Philip L. Saxton, Cathy Reardon, Jiayi Wu, Erin A. Murphy, Galina Kuznetsov, Charles William Johannes, Martin R Tremblay et al. · 2007 · PubMed
175. NMR structure of a complex between MDM2 and a small molecule inhibitor
     David C. Fry, S. Donald Emerson, Stefan Palme, Binh Thanh Vu, Chao‐Min Liu, Frank Podlaski · 2004 · Journal of Biomolecular NMR
176. Clinical Development of Ixabepilone and Other Epothilones in Patients with Advanced Solid Tumors
     Edgardo Rivera, Joyce Lee, Angela M. Davies · 2008 · The Oncologist
177. Rapid treadmilling of brain microtubules free of microtubule-associated proteins in vitro and its suppression by tau
     Dulal Panda, Herbert P. Miller, Leslie Wilson · 1999 · Proceedings of the National Academy of Sciences
178. Three-dimensional structures of proteins involved in programmed cell death
     Heng Liang, Stephen W. Fesik · 1997 · Journal of Molecular Biology
179. The Solid State, Solution and Tubulin-Bound Conformations of Agents that Promote Microtubule Stabilization
     Jesús Jiménez‐Barbero, Francisco Amat‐Guerri, James P. Snyder · 2005 · Anti-Cancer Agents in Medicinal Chemistry
180. The central valine concept provides an entry in a new class of non peptide inhibitors of the p53–MDM2 interaction
     Pascal Furet, Patrick Chêne, Alain De Pover, Therese‐Marie Stachyra, Joanna Hergovich Lisztwan, Joerg A. Kallen, Keiichi Masuya · 2012 · Bioorganic & Medicinal Chemistry Letters
181. Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction
     Karla L. Malloy, Hyukjae Choi, Catherine Fiorilla, Fred A. Valeriote, Teatulohi K. Matainaho, William H. Gerwick · 2011 · Bioorganic & Medicinal Chemistry Letters
182. Characterization of the interaction of cryptophycin 1 with tubulin: binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction.
     R Bai, R E Schwartz, John A. Kepler, G R Pettit, Ernest Hamel · 1996 · PubMed
183. Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity
     Brad E. Sleebs, Peter E. Czabotar, Wayne J. Fairbrother, Walter Douglas Fairlie, John A. Flygare, David C.S. Huang, Wilhelmus J. A. Kersten, Michael F. T. Koehler, Guillaume Lessène, Kym N. Lowes et al. · 2011 · Journal of Medicinal Chemistry
184. Total Synthesis of the Hsp90 Inhibitor Geldanamycin
     Hua‐Li Qin, James S. Panek · 2008 · Organic Letters
185. Syntheses of C-3-Modified Sialylglycosides as Selective Inhibitors of Influenza Hemagglutinin and Neuraminidase
     Xue‐Long Sun, Yoshimi Kanie, Chao-tan Guo, Osamu Kanie, Yasuo Suzuki, Chi‐Huey Wong · 2000 · European Journal of Organic Chemistry
186. New Syntheses of E7389 C14−C35 and Halichondrin C14−C38 Building Blocks: Reductive Cyclization and Oxy-Michael Cyclization Approaches
     Cheng‐Guo Dong, James A. Henderson, Yosuke Kaburagi · 2009 · Journal of the American Chemical Society
187. Targeting FtsZ for antibacterial therapy: a promising avenue
     Sonia Kapoor, Dulal Panda · 2009 · Expert Opinion on Therapeutic Targets
188. The Bound Conformation of Microtubule‐Stabilizing Agents: NMR Insights into the Bioactive 3D Structure of Discodermolide and Dictyostatin
     Ángeles Canales, Ruth Matesanz, Nicola M. Gardner, José M. Andreu, Ian Paterson, José Fernando Díaz, Jesús Jiménez‐Barbero · 2008 · Chemistry - A European Journal
189. Synthesis of (+)-antimycin A3. Use of the oxazole ring in protecting and activating functions
     Harry H. Wasserman, Ronald J. Gambale · 1985 · Journal of the American Chemical Society
190. Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin
     Ruoli Bai, Mary Carmen Roach, Srirangam K. Jayaram, Jozef Barkoczy, George R. Pettit, Richard F. Ludueña, Ernest Hamel · 1993 · Biochemical Pharmacology
191. Radester, a Novel Inhibitor of the Hsp90 Protein Folding Machinery
     Gang Shen, Brian S. J. Blagg · 2005 · Organic Letters
192. Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein
     Hang Hubert Yin, Andrew D. Hamilton · 2004 · Bioorganic & Medicinal Chemistry Letters
193. Modular Asymmetric Synthesis of Pochonin C
     Sofía Barluenga, Pilar López, Émilie Moulin · 2004 · Angewandte Chemie International Edition
194. Structure of herbimycin A new ansamycin antibiotic
     Satoshi Ōmura, Akira Nakagawa, NORIAKI SADAKANE · 1979 · Tetrahedron Letters
195. Terphenyl‐Based Helical Mimetics That Disrupt the p53/HDM2 Interaction
     Hang Hubert Yin, Gui‐in Lee, Hyung Soon Park, Gregory A. Payne, Johanna M. Rodriguez, Saı̈d M. Sebti, Andrew D. Hamilton · 2005 · Angewandte Chemie
196. Design, Synthesis, and Evaluation of a Radicicol and Geldanamycin Chimera, Radamide
     Randell C. Clevenger, Brian S. J. Blagg · 2004 · Organic Letters
197. Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol
     Nicolas Proisy, Swee Y. Sharp, Kathy J. Boxall, Stephen Connelly, Stephen Mark Roe, Chrisostomos Prodromou, Alexandra M. Z. Slawin, Laurence H. Pearl, Paul Workman, Christopher J. Moody · 2006 · Chemistry & Biology
198. Identification of Inhibitors for MDM2 Ubiquitin Ligase Activity from Natural Product Extracts by a Novel High-Throughput Electrochemiluminescent Screen
     Christy A. Sasiela, David Stewart, Jirouta Kitagaki et al. · 2008 · SLAS DISCOVERY
199. Solution‐ and Solid‐Phase Synthesis of Radicicol (Monorden) and Pochonin C
     Sofía Barluenga, Émilie Moulin, Pilar López · 2005 · Chemistry - A European Journal
200. Rigid Dipeptide Mimetics: Efficient Synthesis of Enantiopure Indolizidinone Amino Acids
     Henry‐Georges Lombart, William D. Lubell · 1996 · The Journal of Organic Chemistry