X-Linked Inhibitor of Apoptosis Protein (XIAP) Is a Nonredundant Modulator of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)- Mediated Apoptosis in Human Cancer Cells

IAP family proteins---suppressors of apoptosisPreprint

Deveraux, Q. L., & Reed, J. C. (1999) · Genes & Development · doi:10.1101/gad.13.3.239 · Cited by 2,535 · see citing works

Apoptotic Pathways

Green, D. R. (2000) · Cell · doi:10.1016/s0092-8674(00)00003-9 · Cited by 1,011 · see citing works

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

LaCasse, E. C., Baird, S. D., Korneluk, R. G., & MacKenzie, A. (1998) · Oncogene · doi:10.1038/sj.onc.1202569 · Cited by 980 · see citing works

TRAIL and apoptosis induction by TNF-family death receptors

Wang, S., & El‐Deiry, W. S. (2003) · Oncogene · doi:10.1038/sj.onc.1207232 · Cited by 869 · see citing works

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

Fulda, S., Wick, W., Weller, M., & Debatin, K. (2002) · Nature Medicine · doi:10.1038/nm735 · Cited by 736 · see citing works

The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID

Wang, S. L., Hawkins, C. J., Yoo, S. J., Müller, H. ‐. J., & Hay, B. A. (1999) · Cell · doi:10.1016/s0092-8674(00)81974-1 · Cited by 505 · see citing works

Characterization of XIAP-Deficient Mice

Harlin, H., Reffey, S. B., Duckett, C. S., Lindsten, T., & Thompson, C. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3604-3608.2001 · Cited by 422 · see citing works

Nature's TRAIL—On a Path to Cancer Immunotherapy

Smyth, M. J., Takeda, K., Hayakawa, Y., Peschon, J. J., van den Brink, M. R. M., & Yagita∥, H. (2003) · Immunity · doi:10.1016/s1074-7613(02)00502-2 · Cited by 360 · see citing works

Targeted transgene insertion into human chromosomes by adeno-associated virus vectors

Hirata, R. K., Chamberlain, J. R., Dong, R., & Russell, D. W. (2002) · Nature Biotechnology · doi:10.1038/nbt0702-735 · Cited by 172 · see citing works

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative–(BMS 247550) and Apo-2L/TRAIL–induced apoptosis

Guo, F., Nimmanapalli, R., Paranawithana, S. R., Wittmann, S., Griffin, D. R., Bali, P., O’Bryan, E., Fumero, C., Wang, H., & Bhalla, K. N. (2002) · Blood · doi:10.1182/blood.v99.9.3419 · Cited by 162 · see citing works

Development and Characterization of Nonpeptidic Small Molecule Inhibitors of the XIAP/Caspase-3 Interaction

Wu, T. Y.-H., Wagner, K. W., Bursulaya, B. D., Schultz, P. G., & Deveraux, Q. L. (2003) · Chemistry & Biology · doi:10.1016/s1074-5521(03)00157-1 · Cited by 122 · see citing works

Cell death and cancer therapy

Bunz, F. (2001) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00059-5 · Cited by 72 · see citing works

Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation

Conte, D., Liston, P., Wong, J. W. W., Wright, K. E., & Korneluk, R. G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081547998 · Cited by 60 · see citing works

The saintly side of Smac/DIABLO: giving anticancer drug-induced apoptosis a boost

Arnt, C. R., & Kaufmann, S. H. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401294 · Cited by 24 · see citing works

Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

Lu, H., Zhou, Q., He, J., Jiang, Z., Peng, C., Tong, R., & Shi, J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00315-3 · Cited by 891 · see citing works

Mutant PIK3CA promotes cell growth and invasion of human cancer cells.

Samuels, Y., Diaz, L. A., Schmidt-Kittler, O., Cummins, J. M., DeLong, L., Cheong, I., Rago, C., Huso, D. L., Lengauer, C., Kinzler, K. W., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.014 · Cited by 915 · see citing works

IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer

Gyrd-Hansen, M., & Meier, P. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2889 · Cited by 790 · see citing works

The inhibitors of apoptosis (IAPs) as cancer targets

Hunter, A. M., LaCasse, E. C., & Korneluk, R. G. (2007) · Apoptosis · doi:10.1007/s10495-007-0087-3 · Cited by 565 · see citing works

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works

Life And Death Decisions

Muppidi, J. R., Tschopp, J., & Siegel, R. M. (2004) · Immunity · doi:10.1016/j.immuni.2004.10.001 · Cited by 339 · see citing works

XIAP mediates NOD signaling via interaction with RIP2

Krieg, A. H., Correa, R. G., Garrison, J. B., Negrate, G. L., Welsh, K., Huang, Z., Knoefel, W. T., & Reed, J. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907131106 · Cited by 287 · see citing works

On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics

Dimberg, L. Y., Anderson, C. K., Camidge, D. R., Behbakht, K., Thorburn, A. M., & Ford, H. L. (2012) · Oncogene · doi:10.1038/onc.2012.164 · Cited by 276 · see citing works

XIAP as a ubiquitin ligase in cellular signaling

Galbán, S., & Duckett, C. S. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.81 · Cited by 217 · see citing works

The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer

Vucic, D., & Fairbrother, W. J. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0729 · Cited by 208 · see citing works

Adeno-associated virus vector integration.

Deyle, D. R., & Russell, D. W. (2009) · PubMed · Cited by 206 · see citing works

SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP

Lü, J., Bai, L., Sun, H., Nikolovska‐Coleska, Z., McEachern, D., Qiu, S., Miller, R. S., Han, Y., Shangary, S. K., Sun, Y., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2655 · Cited by 200 · see citing works

Regulation of apoptosis by XIAP ubiquitin-ligase activityPreprint

Schile, A. J., García-Fernández, M., & Steller, H. (2008) · Genes & Development · doi:10.1101/gad.1663108 · Cited by 194 · see citing works

AAV-mediated gene targeting methods for human cells

Khan, I., Hirata, R. K., & Russell, D. W. (2011) · Nature Protocols · doi:10.1038/nprot.2011.301 · Cited by 188 · see citing works

Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs

Zobel, K., Wang, L., Varfolomeev, E. E., Franklin, M. C., Elliott, L. O., Wallweber, H. J. A., Okawa, D. C., Flygare, J. A., Vucic, D., Fairbrother, W. J., et al. (2006) · ACS Chemical Biology · doi:10.1021/cb600276q · Cited by 175 · see citing works

TRAIL as a target in anti-cancer therapy

Wu, G. S. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.02.029 · Cited by 170 · see citing works

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

McManus, D. C., Lefebvre, C. A., Cherton-Horvat, G., St-Jean, M., Kandimalla, E. R., Agrawal, S., Morris, S. J., Durkin, J. P., & LaCasse, E. C. (2004) · Oncogene · doi:10.1038/sj.onc.1207967 · Cited by 169 · see citing works

Lessons from TRAIL-resistance mechanisms in colorectal cancer cells: paving the road to patient-tailored therapy

van Geelen, C. M. M., de Vries, E. G. E., & de Jong, S. (2004) · Drug Resistance Updates · doi:10.1016/j.drup.2004.11.002 · Cited by 166 · see citing works

Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer

Ismail, N. I., Othman, I., Abas, F., Lajis, N. H., & Naidu, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102454 · Cited by 170 · see citing works

TRAIL Agonists on Clinical Trials for Cancer Therapy: The Promises and the Challenges

Bellail, A. C., Qi, L., Mulligan, P., Chhabra, V. S., & Hao, C. (2009) · Reviews on Recent Clinical Trials · doi:10.2174/157488709787047530 · Cited by 158 · see citing works

TRAIL receptor-targeted therapeutics: Resistance mechanisms and strategies to avoid them

Thorburn, A. M., Behbakht, K., & Ford, H. L. (2008) · Drug Resistance Updates · doi:10.1016/j.drup.2008.02.001 · Cited by 160 · see citing works

Colon cancer and apoptosis

Huerta, S., Goulet, E. J., & Livingston, E. H. (2006) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2005.11.009 · Cited by 158 · see citing works

TRAIL receptor signaling and therapeutics

Abdulghani, J., & El‐Deiry, W. S. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.519701 · Cited by 154 · see citing works

XIAP variants in male Crohn's disease

Zeißig, Y., Petersen, B., Milutinovic, S., Bosse, E., Mayr, G., Peuker, K., Hartwig, J., Keller, A., Kohl, M., Laass, M. W., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-306520 · Cited by 156 · see citing works

Targeting apoptosis as an approach for gastrointestinal cancer therapy

Qiao, L., & Yu, W. B. C. (2009) · Drug Resistance Updates · doi:10.1016/j.drup.2009.02.002 · Cited by 153 · see citing works

Disease‐causing mutations in the XIAP BIR2 domain impair NOD2‐dependent immune signalling

Damgaard, R. B., Fiil, B. K., Speckmann, C., Yabal, M., Stadt, U. Z., Bekker‐Jensen, S., Jost, P. J., Ehl, S. R., Mailand, N., & Gyrd‐Hansen, M. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201303090 · Cited by 148 · see citing works

Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation

Yang, A., Wilson, N. S., & Ashkenazi, A. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.08.001 · Cited by 140 · see citing works

Phytochemicals As Chemosensitizers: From Molecular Mechanism to Clinical Significance

Balachandran, V., Maliekal, T. T., & Anto, R. J. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4573 · Cited by 139 · see citing works

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5

Carter, B. Z., Mak, D. H. F., Schober, W. D., Dietrich, M. F., Pinilla, C., Vassilev, L. T., Reed, J. C., & Andreeff, M. (2008) · Blood · doi:10.1182/blood-2007-05-091504 · Cited by 134 · see citing works

D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1

Choi, S.-S., Lew, K. L., Xiao, H., Herman-Antosiewicz, A., Xiao, D., Brown, C., & Singh, S. V. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl144 · Cited by 132 · see citing works

Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis

LaCasse, E. C., Cherton-Horvat, G. G., Hewitt, K. E., Jerome, L. J., Morris, S. J., Kandimalla, E. R., Yu, D., Wang, H., Wang, W., Zhang, R., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0608 · Cited by 128 · see citing works

Precise hit: adeno-associated virus in gene targeting

Vasileva, A., & Jessberger, R. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1266 · Cited by 148 · see citing works

Gene targeting with viral vectors

Hendrie, P. C., & Russell, D. W. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.04.006 · Cited by 126 · see citing works

Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress–induced cell death during the unfolded protein response

Hiramatsu, N., Messah, C., Han, J., LaVail, M. M., Kaufman, R. J., & Lin, J. H. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-11-0664 · Cited by 125 · see citing works

Repeated Recruitment of LTR Retrotransposons as Promoters by the Anti-Apoptotic Locus NAIP during Mammalian Evolution

Romanish, M. T., Lock, W. M., van de Lagemaat, L. N., Dunn, C. A., & Mager, D. L. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0030010 · Cited by 124 · see citing works

Genetic knockouts and knockins in human somatic cells

Rago, C., Vogelstein, B., & Bunz, F. (2007) · Nature Protocols · doi:10.1038/nprot.2007.408 · Cited by 120 · see citing works

Phosphorylation of eIF2α at Serine 51 Is an Important Determinant of Cell Survival and Adaptation to Glucose Deficiency

Muaddi, H., Majumder, M., Peidis, P., Papadakis, A. I., Holčı́k, M., Scheuner, D. L., Kaufman, R. J., Hatzoglou, M., & Koromilas, A. E. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-01-0023 · Cited by 116 · see citing works

Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism

Allensworth, J. L., Sauer, S. J., Lyerly, H. K., Morse, M. A., & Devi, G. R. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2352-6 · Cited by 112 · see citing works

Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells

Vogler, M., Dürr, K., Jovanovic, M., Debatin, K., & Fulda, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209776 · Cited by 109 · see citing works

MCL-1 as a Buffer for Proapoptotic BCL-2 Family Members during TRAIL-induced Apoptosis

Meng, X. W., Lee, S. H., Dai, H., Loegering, D. A., Yu, C., Flatten, K. S., Schneider, P. A., Dai, N. T., Kumar, S. K., Smith, B. D., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706110200 · Cited by 108 · see citing works

Increased expression of inhibitor of apoptosis proteins, survivin and XIAP, in non-small cell lung carcinoma

Krepela, E. (2009) · International Journal of Oncology · doi:10.3892/ijo_00000464 · Cited by 100 · see citing works

Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells

Mazurek, N., Byrd, J. C., Sun, Y., Hafley, M., Ramirez, K., Burks, J., & Bresalier, R. S. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.123 · Cited by 96 · see citing works

Computational Analysis of Dynamical Responses to the Intrinsic Pathway of Programmed Cell Death

Zhang, T., Brazhnik, P., & Tyson, J. J. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.04.053 · Cited by 96 · see citing works

Constitutively Activated Nuclear Factor-κB, but not Induced NF-κB, Leads to TRAIL Resistance by Up-Regulation of X-Linked Inhibitor of Apoptosis Protein in Human Cancer Cells

Braeuer, S. J., Büneker, C. K., Mohr, A., & Zwacka, R. M. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0231 · Cited by 92 · see citing works

Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS–JNK–CHOP-mediated upregulation of death receptors

Sung, B., Prasad, S., Ravindran, J., Yadav, V. R., & Aggarwal, B. B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.012 · Cited by 90 · see citing works

Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein

Karikari, C. A., Roy, I., Tryggestad, E., Feldmann, G., Pinilla, C., Welsh, K., Reed, J. C., Armour, E. P., Wong, J. W., Herman, J. M., et al. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0634 · Cited by 87 · see citing works

Interferon-activated neutrophils store a TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) intracellular pool that is readily mobilizable following exposure to proinflammatory mediators

Cassatella, M. A., Huber, V., Calzetti, F., Margotto, D., Tamassia, N., Peri, G., Mantovani, A., Rivoltini, L., & Tecchio, C. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0805431 · Cited by 82 · see citing works

Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer

Foster, F. M., Owens, T. W., Tanianis-Hughes, J., Clarke, R. B., Brennan, K. R., Bundred, N. J., & Streuli, C. H. (2009) · Breast Cancer Research · doi:10.1186/bcr2328 · Cited by 82 · see citing works

Small-molecule pan-IAP antagonists: a patent review

Flygare, J. A., & Fairbrother, W. J. (2010) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770903567077 · Cited by 80 · see citing works

GlutathioneS-Transferase π1 Promotes Tumorigenicity in HCT116 Human Colon Cancer Cells

Dang, D. T., Chen, F., Kohli, M., Rago, C., Cummins, J. M., & Dang, L. H. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1930 · Cited by 80 · see citing works

Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway

Trivedi, R., Maurya, R., & Mishra, D. P. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.429 · Cited by 80 · see citing works

Small molecule modulators of protein-protein interactions: selected case studies

Aeluri, M., Chamakuri, S., Dasari, B., Guduru, S. K. R., Jimmidi, R., Jogula, S., & Arya, P. (2014) · Chemical Reviews · doi:10.1021/cr4004049 · Cited by 79 · see citing works

X-linked Inhibitor of Apoptosis Protein (XIAP) Mediates Cancer Cell Motility via Rho GDP Dissociation Inhibitor (RhoGDI)-dependent Regulation of the Cytoskeleton

Liu, J., Zhang, D., Luo, W., Yu, Y., Yu, J., Li, J., Zhang, X., Zhang, B., Chen, J., Wu, X., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.176982 · Cited by 76 · see citing works

Peroxisome Proliferator-Activated Receptor-γ Contributes to the Inhibitory Effects of Embelin on Colon Carcinogenesis

Dai, Y., Qiao, L., Chan, K. W., Yang, M., Ye, J., Ma, J., Zou, B., Gu, Q., Wang, J., Pang, R. W. C., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4754 · Cited by 77 · see citing works

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

Lecis, D., Drago, C., Manzoni, L., Seneci, P., Scolastico, C., Mastrangelo, E., Bolognesi, M., Anichini, A., Kashkar, H., Walczak, H., et al. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605687 · Cited by 77 · see citing works

A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB

Dai, Y., Liu, M., Tang, W., Li, Y., Lian, J., Lawrence, T. S., & Xu, L. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-392 · Cited by 72 · see citing works

XIAP Inhibition and Generation of Reactive Oxygen Species Enhances TRAIL Sensitivity in Inflammatory Breast Cancer Cells

Allensworth, J. L., Aird, K. M., Aldrich, A. J., Batinic̈‐Haberle, I., & Devi, G. R. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0787 · Cited by 71 · see citing works

Acquired TRAIL resistance in human breast cancer cells are caused by the sustained cFLIPL and XIAP protein levels and ERK activation

Lee, T.-J., Lee, J. T., Park, J., & Kwon, T. K. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.163 · Cited by 70 · see citing works

RhoGDI SUMOylation at Lys-138 Increases Its Binding Activity to Rho GTPase and Its Inhibiting Cancer Cell Motility

Yu, J., Zhang, D., Liu, J., Li, J., Yu, Y., Wu, X., & Huang, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.337469 · Cited by 69 · see citing works

Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer

Song, X., Kim, S.-Y., Zhang, L., Tang, D., Bartlett, D. L., Kwon, Y. T., & Lee, Y. J. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.463 · Cited by 68 · see citing works

The Chinese Herb Isolate Isorhapontigenin Induces Apoptosis in Human Cancer Cells by Down-regulating Overexpression of Antiapoptotic Protein XIAP

Fang, Y., Yu, Y., Hou, Q., Zheng, X., Zhang, M., Zhang, D., Li, J., Wu, X., & Huang, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.389494 · Cited by 68 · see citing works

Recurrent Genomic Alterations With Impact on Survival in Colorectal Cancer Identified by Genome-Wide Array Comparative Genomic Hybridization

Kim, M., Yim, S., Kwon, M., Kim, T., Shin, S., Kang, H. M., Lee, C., & Chung, Y. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.021 · Cited by 68 · see citing works

SMAC/Diablo -dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells

Kohli, M., Yu, J., Seaman, C. D., Bardelli, A., Kinzler, K. W., Vogelstein, B., Christoph Lengauer, C., & Zhang, L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403405101 · Cited by 68 · see citing works

Lyapunov exponents and phase diagrams reveal multi‐factorial control over TRAIL‐induced apoptosis

Aldridge, B. B., Gaudet, S., Lauffenburger, D. A., & Sorger, P. K. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.85 · Cited by 66 · see citing works

Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion

Shirley, S., Morizot, A., & Micheau, O. (2011) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/157489211796957757 · Cited by 66 · see citing works

Therapeutic Potential and Molecular Mechanism of a Novel, Potent, Nonpeptide, Smac Mimetic SM-164 in Combination with TRAIL for Cancer Treatment

Lü, J., McEachern, D., Sun, H., Bai, L., Peng, Y., Qiu, S., Miller, R. S., Liao, J., Han, Y., Liu, M., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0864 · Cited by 66 · see citing works

Frequent Alteration of XAF1 in Human Colorectal Cancers: Implication for Tumor Cell Resistance to Apoptotic Stresses

Chung, S., Lee, M., Ryu, B., Lee, J., Han, J., Byun, D., Chae, K. S., Lee, K. Y., Jang, J., Kim, H. J., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.024 · Cited by 63 · see citing works

Application of XIAP Antisense to Cancer and Other Proliferative Disorders: Development of AEG35156/ GEM®640

LaCasse, E. C., Kandimalla, E. R., Winocour, P. D., SULLIVAN, T., Agrawal, S., Gillard, J. W., & Durkin, J. P. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1359.032 · Cited by 63 · see citing works

Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation

Rosato, R. R., Dai, Y., Almenara, J. A., Maggio, S. C., & Grant, S. (2004) · Leukemia · doi:10.1038/sj.leu.2403491 · Cited by 63 · see citing works

Inducible Resistance of Tumor Cells to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Receptor 2–Mediated Apoptosis by Generation of a Blockade at the Death Domain Function

Li, Y., Wang, H., Wang, Z., Makhija, S. K., Buchsbaum, D. J., LoBuglio, A. F., Kimberly, R. P., & Zhou, T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4364 · Cited by 61 · see citing works

Targeting death receptors for TRAIL by agents designed by Mother Nature

Prasad, S., Kim, J. H., Gupta, S. C., & Aggarwal, B. B. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.07.004 · Cited by 60 · see citing works

Sensitization of pancreatic carcinoma cells for γ-irradiation-induced apoptosis by XIAP inhibition

Giagkousiklidis, S., Vellanki, S. H., Debatin, K., & Fulda, S. (2007) · Oncogene · doi:10.1038/sj.onc.1210502 · Cited by 58 · see citing works

Loss of ataxia telangiectasia mutated– and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival

Wilsker, D. F., & Bunz, F. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0679 · Cited by 57 · see citing works

Association of cooking oil fumes exposure with lung cancer: Involvement of inhibitor of apoptosis proteins in cell survival and proliferation in vitro

Hung, H., Wu, W.-J., Cheng, Y., Wu, T.-C., Chang, K., & Lee, H. (2006) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2006.12.005 · Cited by 55 · see citing works

Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells

Wilson, T. R., McEwan, M. V., McLaughlin, K. M., Clorennec, C. L., Allen, W. L., Fennell, D. A., Johnston, P. G., & Longley, D. B. (2008) · Oncogene · doi:10.1038/onc.2008.366 · Cited by 53 · see citing works

Fragment-Based Design of Small Molecule X-Linked Inhibitor of Apoptosis Protein Inhibitors

Huang, J., Zhang, Z., Wu, B., Cellitti, J. F., Zhang, X., Dahl, R. S., Shiau, C., Welsh, K., Emdadi, A., Stebbins, J. L., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm8006992 · Cited by 55 · see citing works

Targeting cell death signaling in colorectal cancer: Current strategies and future perspectives

Koehler, B. C. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i8.1923 · Cited by 54 · see citing works

Pulling the plug on a cancer cell by eliminating XIAP with AEG35156

LaCasse, E. C. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.06.015 · Cited by 54 · see citing works

Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin‐induced apoptosis

Joy, B., Sivadasan, R., Abraham, E. T., John, M., Sobhan, P. K., Seervi, M., & Santhoshkumar, T. R. (2009) · Molecular Carcinogenesis · doi:10.1002/mc.20599 · Cited by 54 · see citing works

Inhibition of MKK7–JNK by the TOR Signaling Pathway Regulator-Like Protein Contributes to Resistance of HCC Cells to TRAIL-Induced Apoptosis

Song, I. S., Jun, S. Y., Na, H., Kim, H., Jung, S. Y., Ha, G., Park, Y., Long, L. Z., Yu, D., Kim, J., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.103 · Cited by 52 · see citing works

The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells

Kauntz, H., Bousserouel, S., Gossé, F., & Raul, F. (2012) · APOPTOSIS · doi:10.1007/s10495-012-0731-4 · Cited by 52 · see citing works

Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3

Lane, D. A., Côté, M., Grondin, R., Couture, M.-C., & Piché, A. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0362 · Cited by 50 · see citing works

Oxidative stress-driven DR5 upregulation restores TRAIL/Apo2L sensitivity induced by iron oxide nanoparticles in colorectal cancer

Shi, Y., Wang, J., Liu, J., Lin, G., Xie, F., Pang, X., Pei, Y., Cheng, Y., Zhang, Y., Lin, Z., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119753 · Cited by 50 · see citing works

Double inhibition of XIAP and Bcl-2 axis is beneficial for retrieving sensitivity of renal cell cancer to apoptosis

Bilim, V. N., Yuuki, K., Itoi, T., Muto, A., Kato, T., Nagaoka, A., Motoyama, T., & Tomita, Y. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604268 · Cited by 50 · see citing works

TRAIL‐Induced Apoptosis

Corazza, N., Kassahn, D., Jakob, S., Badmann, A., & Brunner, T. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04905.x · Cited by 49 · see citing works

Anti-tumor activity of the X-linked inhibitor of apoptosis (XIAP) inhibitor embelin in gastric cancer cells

Wang, D., Sun, Y., Ye, F., Li, W., Kharbuja, P., Gao, L., Zhang, D. Y., & Suo, J. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1853-x · Cited by 49 · see citing works

Cytoprotective effects of IAPs revealed by a small molecule antagonist

Galbán, S., Hwang, C., Rumble, J. M., Oetjen, K. A., Wright, C. W., Boudreault, A., Durkin, J. P., Gillard, J. W., Jaquith, J. B., Morris, S. J., et al. (2008) · Biochemical Journal · doi:10.1042/bj20081677 · Cited by 49 · see citing works

CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48

Dang, L. H., Chen, F., Ying, C., Chun, S. Y., Knock, S. A., Appelman, H. D., & Dang, D. T. (2005) · Oncogene · doi:10.1038/sj.onc.1209247 · Cited by 49 · see citing works

Sulindac sulfide–induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2

Sinicrope, F. A., & Penington, R. C. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0137 · Cited by 49 · see citing works

Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma

Guttà, C., Rahman, A., Aura, C. M., Dynoodt, P., Charles, E. M., Hirschenhahn, E., Joseph, J., Wouters, J., de Chaumont, C., Rafferty, M., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2309-3 · Cited by 48 · see citing works

Caspase-8 as a Regulator of Tumor Cell Motility

Graf, R. P., Keller, N., Barbero, S., & Stupack, D. G. (2014) · Current Molecular Medicine · doi:10.2174/1566524014666140128111951 · Cited by 48 · see citing works

The role of XIAP in resistance to TNF-related apoptosis-inducing ligand (TRAIL) in Leukemia

Saraei, R., Soleimani, M., Akbari, A. A. M., Hagh, M. F., Hassanzadeh, A., & Solali, S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.065 · Cited by 48 · see citing works

Combined modality therapy with TRAIL or agonistic death receptor antibodies

Amm, H. M., Oliver, P. G., Lee, C. H., Li, Y., & Buchsbaum, D. J. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.5.14671 · Cited by 47 · see citing works

Clinical significance of Smac/DIABLO expression in colorectal cancer

Endo (1994) · Oncology Reports · doi:10.3892/or_00000229 · Cited by 46 · see citing works

17-Allylamino-17-demethoxygeldanamycin overcomes TRAIL resistance in colon cancer cell lines

Vasilevskaya, I. A., & O'Dwyer, P. J. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.05.018 · Cited by 46 · see citing works

The Chinese Herb Isolate Yuanhuacine (YHL-14) Induces G2/M Arrest in Human Cancer Cells by Up-regulating p21 Protein Expression through an p53 Protein-independent Cascade

Zhang, R., Wang, Y., Li, J., Jin, H., Song, S., & Huang, C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.513960 · Cited by 45 · see citing works

Carnosic acid cooperates with tamoxifen to induce apoptosis associated with Caspase-3 activation in breast cancer cells in vitro and in vivo

Han, N., Zhou, Q., Huang, Q., & Liu, K. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.084 · Cited by 45 · see citing works

Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide

Günther, S. D., Fritsch, M., Seeger, J. M., Schiffmann, L. M., Snipas, S. J., Coutelle, M., Kufer, T. A., Higgins, P. G., Hornung, V., Bernardini, M. L., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0620-5 · Cited by 45 · see citing works

Cell death pathways – potential therapeutic targets

MacFarlane, M. (2009) · Xenobiotica · doi:10.1080/00498250903137990 · Cited by 44 · see citing works

Bortezomib Sensitizes Non–Hodgkin's Lymphoma Cells to Apoptosis Induced by Antibodies to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (TRAIL) Receptors TRAIL-R1 and TRAIL-R2

Smith, M. R., Jin, F., & Joshi, I. D. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0982 · Cited by 43 · see citing works

XIAP is not required for human tumor cell survival in the absence of an exogenous death signal

Sensintaffar, J., Scott, F. L., Peach, R., & Hager, J. H. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-11 · Cited by 21 · see citing works

Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells

Vogler, M., Dürr, K., Jovanovic, M., Debatin, K., & Fulda, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209776 · Cited by 109 · see citing works

The role of XIAP in resistance to TNF-related apoptosis-inducing ligand (TRAIL) in Leukemia

Saraei, R., Soleimani, M., Akbari, A. A. M., Hagh, M. F., Hassanzadeh, A., & Solali, S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.065 · Cited by 48 · see citing works

Abstract P1-04-01: X-Linked Inhibitor of Apoptosis Protein (XIAP) Regulates TRAIL-Induced Apoptosis in Inflammatory Breast Cancer Cells

Allensworth, J. L., Aird, K. M., Murray, M., & Devi, G. P. (2010) · Cancer Research · doi:10.1158/0008-5472.sabcs10-p1-04-01 · Cited by 1 · see citing works

Targeting XIAP Bypasses Bcl-2–Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

Vogler, M., Walczak, H., Stadel, D., Haas, T. L., Genze, F., Jovanovic, M., Gschwend, J. E., Simmet, T., Debatin, K., & Fulda, S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1296 · Cited by 148 · see citing works