Identification of intrinsically disordered regions in PTEN and delineation of its function via a network approach

Cytoscape: A software Environment for integrated models of biomolecular interaction networks

Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888 · see citing works

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455 · see citing works

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160 · see citing works

Network medicine: a network-based approach to human disease

Barabási, A.-L., Gulbahce, N., & Loscalzo, J. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2918 · Cited by 5,034 · see citing works

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Maehama, T., & Dixon, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13375 · Cited by 3,104 · see citing works

Intrinsically disordered protein

Dunker, A. K., Lawson, J. D., Brown, C. J., Williams, R. M., Romero, P., Oh, J. S., Oldfield, C. J., Campen, A. M., Ratliff, C. M., Hipps, K. W., et al. (2001) · Journal of Molecular Graphics and Modelling · doi:10.1016/s1093-3263(00)00138-8 · Cited by 2,272 · see citing works

The functions and regulation of the PTEN tumour suppressor

Song, M. S., Salmena, L., & Pandolfi, P. P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3330 · Cited by 1,926 · see citing works

Intrinsically Disordered Proteins in Human Diseases: Introducing the D 2 Concept

Uversky, V. N., Oldfield, C. J., & Dunker, A. K. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125924 · Cited by 1,406 · see citing works

Coupling of folding and binding for unstructured proteins

Dyson, H. J., & Wright, P. E. (2002) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(02)00289-0 · Cited by 1,327 · see citing works

Intrinsic Disorder in Cell-signaling and Cancer-associated Proteins

Iakoucheva, L. M., Brown, C. J., Lawson, J. D., Obradović, Z., & Dunker, A. K. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00969-5 · Cited by 1,214 · see citing works

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

Xue, B., Dunbrack, R. L., Williams, R. W., Dunker, A. K., & Uversky, V. N. (2010) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2010.01.011 · Cited by 1,208 · see citing works

The small world inside large metabolic networks

Wagner, A., & Fell, D. A. (2001) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2001.1711 · Cited by 986 · see citing works

Structure and dynamics of molecular networks: A novel paradigm of drug discovery

Csermely, P., Korcsmáros, T., Kiss, H., London, G., & Nussinov, R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.016 · Cited by 889 · see citing works

The Human Gene Mutation Database: 2008 update

Stenson, P. D., Mort, M., Ball, E. V., Howells, K., Phillips, A. D., Thomas, N. S., & Cooper, D. N. (2009) · Genome Medicine · doi:10.1186/gm13 · Cited by 873 · see citing works

PTEN loss in the continuum of common cancers, rare syndromes and mouse models

Hollander, M. C., Blumenthal, G. M., & Dennis, P. A. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3037 · Cited by 793 · see citing works

Phosphorylation of the PTEN Tail Regulates Protein Stability and Function

Vázquez, F., Ramaswamy, S., Nakamura, N., & Sellers, W. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5010-5018.2000 · Cited by 777 · see citing works

Analysis of Molecular Recognition Features (MoRFs)

Mohan, A., Oldfield, C. J., Predrag Radivojac, A., Vacic, V., Cortese, M. S., Dunker, A. K., & Uversky, V. N. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.07.087 · Cited by 746 · see citing works

Intrinsic Disorder and Functional Proteomics

Predrag Radivojac, A., Iakoucheva, L. M., Oldfield, C. J., Zoran Obradovic, A., Uversky, V. N., & Dunker, A. K. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.094045 · Cited by 705 · see citing works

Intrinsically disordered proteins: regulation and disease

Babu, M. M., van der Lee, R., de Groot, N. S., & Gsponer, J. A. (2011) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2011.03.011 · Cited by 597 · see citing works

Intrinsic Disorder Is a Common Feature of Hub Proteins from Four Eukaryotic Interactomes

Haynes, C. A., Oldfield, C. J., Ji, F., Klitgord, N., Cusick, M. E., Predrag Radivojac, A., Uversky, V. N., Vidal, M., & Iakoucheva, L. M. (2006) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0020100 · Cited by 583 · see citing works

Molecular mechanisms underlying RB protein function

Dick, F. A., & Rubin, S. M. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3567 · Cited by 570 · see citing works

Getting connected: analysis and principles of biological networksPreprint

Zhu, X., Gerstein, M., & Snyder, M. P. (2007) · Genes & Development · doi:10.1101/gad.1528707 · Cited by 549 · see citing works

PTEN

Worby, C. A., & Dixon, J. E. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-082411-113907 · Cited by 540 · see citing works

Global topological features of cancer proteins in the human interactome

Jonsson, P. F., & Bates, P. A. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl390 · Cited by 490 · see citing works

Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation

Gsponer, J., Futschik, M. E., Teichmann, S. A., & Babu, M. M. (2008) · Science · doi:10.1126/science.1163581 · Cited by 466 · see citing works

Discovering disease-genes by topological features in human protein–protein interaction network

Xu, J., & Li, Y. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl467 · Cited by 461 · see citing works

ELM--the database of eukaryotic linear motifs

Dinkel, H., Michael, S., Weatheritt, R. J., Davey, N. E., Roey, K. V., Altenberg, B., Toedt, G., Uyar, B., Seiler, M., Budd, A., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1064 · Cited by 439 · see citing works

Composition Profiler: a tool for discovery and visualization of amino acid composition differences

Vacic, V., Uversky, V. N., Dunker, A. K., & Lonardi, S. (2007) · BMC Bioinformatics · doi:10.1186/1471-2105-8-211 · Cited by 428 · see citing works

Predicting intrinsic disorder in proteins: an overview

He, B., Wang, K., Liu, Y., Xue, B., Uversky, V. N., & Dunker, A. K. (2009) · Cell Research · doi:10.1038/cr.2009.87 · Cited by 426 · see citing works

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain

Wells, M. A., Tidow, H., Rutherford, T. J., Markwick, P. R. L., Jensen, M. R., Mylonas, E., Svergun, D. I., Blackledge, M. J., & Fersht, A. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801353105 · Cited by 420 · see citing works

Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues

Wachi, S., Yoneda, K. Y., & Wu, R. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti688 · Cited by 406 · see citing works

Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress

Bassi, C., Ho, J., Srikumar, T., Dowling, R. J. O., Gorrini, C., Miller, S. J., Mak, T. W., Neel, B. G., Raught, B., & Stambolic, V. (2013) · Science · doi:10.1126/science.1236188 · Cited by 403 · see citing works

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

Wu, X., Hepner, K., Castelino‐Prabhu, S., Do, D., Kaye, M. B., Yuan, X., Wood, J., Ross, C. A., Sawyers, C. L., & Whang, Y. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4233 · Cited by 398 · see citing works

Understanding eukaryotic linear motifs and their role in cell signaling and regulation

Diella, F. (2008) · Frontiers in bioscience · doi:10.2741/3175 · Cited by 338 · see citing works

Extended disordered proteins: targeting function with less scaffold

Gunasekaran, K., Tsai, C., Kumar, S., Zanuy, D., & Nussinov, R. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00003-3 · Cited by 338 · see citing works

Membrane-binding and activation mechanism of PTEN

Das, S., Dixon, J. E., & Cho, W. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0932835100 · Cited by 336 · see citing works

A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival

Hopkins, B. D., Fine, B. M., Steinbach, N., Dendy, M., Rapp, Z., Shaw, J. M., Pappas, K., Yu, J. S., Hodakoski, C., Mense, S. M., et al. (2013) · Science · doi:10.1126/science.1234907 · Cited by 325 · see citing works

Protein-protein interfaces: Analysis of amino acid conservation in homodimers

Valdar, W. S. J., & Thornton, J. M. (2000) · Proteins Structure Function and Bioinformatics · doi:10.1002/1097-0134(20010101)42:1 · Cited by 322 · see citing works

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

Putz, U., Howitt, J. A., Doan, A., Goh, C., Low, L., Silke, J., & Tan, S. (2012) · Science Signaling · doi:10.1126/scisignal.2003084 · Cited by 312 · see citing works

PTEN function: the long and the short of it

Hopkins, B. D., Hodakoski, C., Barrows, D., Mense, S. M., & Parsons, R. E. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.006 · Cited by 309 · see citing works

The nuclear affairs of PTEN

Planchon, S. M., Waite, K. A., & Eng, C. (2008) · Journal of Cell Science · doi:10.1242/jcs.022459 · Cited by 295 · see citing works

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases

Uversky, V. N., Davé, V., Iakoucheva, L. M., Malaney, P., Metallo, S. J., Pathak, R. R., & Joerger, A. C. (2014) · Chemical Reviews · doi:10.1021/cr400713r · Cited by 288 · see citing works

Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function

Papa, A., Wan, L., Bonora, M., Salmena, L., Song, M. S., Hobbs, R. M., Lunardi, A., Webster, K. A., Ng, C., Newton, R. H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.027 · Cited by 277 · see citing works

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN

Rahdar, M., Inoue, T., Meyer, T., Zhang, J., Vázquez, F., & Devreotes, P. N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811212106 · Cited by 266 · see citing works

From Sequence and Forces to Structure, Function, and Evolution of Intrinsically Disordered Proteins

Forman-Kay, J. D., & Mittag, T. (2013) · Structure · doi:10.1016/j.str.2013.08.001 · Cited by 259 · see citing works

Structure of the Rb C-Terminal Domain Bound to E2F1-DP1: A Mechanism for Phosphorylation-Induced E2F Release

Rubin, S. M., Gall, A.-L., Zheng, N., & Pavletich, N. P. (2005) · Cell · doi:10.1016/j.cell.2005.09.044 · Cited by 253 · see citing works

Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner

Bononi, A., Bonora, M., Marchi, S., Missiroli, S., Poletti, F., Giorgi, C., Pandolfi, P. P., & Pinton, P. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.77 · Cited by 237 · see citing works

PTENα, a PTEN Isoform Translated through Alternative Initiation, Regulates Mitochondrial Function and Energy Metabolism

Liang, H., He, S., Yang, J., Jia, X., Wang, P., Chen, X., Zhang, Z., Zou, X., McNutt, M. A., Shen, W. H., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.023 · Cited by 235 · see citing works

Binding of PTEN to Specific PDZ Domains Contributes to PTEN Protein Stability and Phosphorylation by Microtubule-associated Serine/Threonine Kinases

Valiente, M., Andrés‐Pons, A., Gomar, B., Torres, J., Gil, A., Tapparel, C., Antonarakis, S. E., & Pulido, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504761200 · Cited by 219 · see citing works

Structural Characterization of Intrinsically Disordered Proteins by NMR Spectroscopy

Kosol, S., Contreras-Martos, S., Cedeño, C., & Tompa, P. (2013) · Molecules · doi:10.3390/molecules180910802 · Cited by 199 · see citing works

Comparing Models of Evolution for Ordered and Disordered Proteins

Brown, C. J., Johnson, A. K., & Daughdrill, G. W. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp277 · Cited by 197 · see citing works

Retinoblastoma Protein Contains a C-terminal Motif That Targets It for Phosphorylation by Cyclin-cdk Complexes

Adams, P. D., Li, X., Sellers, W. R., Baker, K., Leng, X., Harper, J. W., Taya, Y., & Kaelin, W. G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1068 · Cited by 185 · see citing works

Analysis of Ordered and Disordered Protein Complexes Reveals Structural Features Discriminating Between Stable and Unstable Monomers

Gunasekaran, K., Tsai, C., & Nussinov, R. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.07.002 · Cited by 177 · see citing works

Characterization of Segments from the Central Region of BRCA1: An Intrinsically Disordered Scaffold for Multiple Protein–Protein and Protein–DNA Interactions?

Mark, W.-Y., Liao, J. C. C., Lü, Y., Ayed, A., Laister, R. C., Szymczyna, B. R., Chakrabartty, A., & Arrowsmith, C. H. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.10.045 · Cited by 175 · see citing works

Regulation of PTEN Activity by Its Carboxyl-terminal Autoinhibitory Domain

Odriozola, L., Singh, G., Hoang, T., & Chan, A. M.-L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611240200 · Cited by 160 · see citing works

PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression

Chang, C.-J., Mulholland, D. J., Valamehr, B., Mosessian, S., Sellers, W. R., & Wu, H. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00310-08 · Cited by 155 · see citing works

Phosphorylation-induced Conformational Changes in the Retinoblastoma Protein Inhibit E2F Transactivation Domain Binding

Burke, J. R., Deshong, A. J., Pelton, J. G., & Rubin, S. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.108167 · Cited by 148 · see citing works

Nuclear Localization of PTEN by a Ran-dependent Mechanism Enhances Apoptosis: Involvement of an N-Terminal Nuclear Localization Domain and Multiple Nuclear Exclusion Motifs

Gil, A., Andrés‐Pons, A., Fernández, E., Valiente, M., Torres, J., Cervera, J., & Pulido, R. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0380 · Cited by 143 · see citing works

Phosphorylation-regulated Cleavage of the Tumor Suppressor PTEN by Caspase-3

Torres, J., Rodriguez, J., Myers, M. P., Valiente, M., Graves, J. D., Tonks, N. K., & Pulido, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212610200 · Cited by 136 · see citing works

Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle controlPreprint

Burke, J. R., Hura, G. L., & Rubin, S. M. (2012) · Genes & Development · doi:10.1101/gad.189837.112 · Cited by 134 · see citing works

Regulation of the Tumor Suppressor PTEN through Exosomes: A Diagnostic Potential for Prostate Cancer

Gabriel, K., Ingram, A. J., Austin, R. C., Kapoor, A., Tang, D., Majeed, F., Qureshi, T. M., & Al-Nedawi, K. N. I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070047 · Cited by 129 · see citing works

Proteome-Wide Discovery of Evolutionary Conserved Sequences in Disordered Regions

Ba, A. N. N., Yeh, B. J., van Dyk, D., Davidson, A. R., Andrews, B., Weiss, E. L., & Moses, A. M. (2012) · Science Signaling · doi:10.1126/scisignal.2002515 · Cited by 129 · see citing works

Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism

Takeuchi, K., Gertner, M. J., Zhou, J., Parada, L. F., Bennett, M. V. L., & Zukin, R. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222803110 · Cited by 119 · see citing works

Intrinsic Disorder in Protein Interactions: Insights From a Comprehensive Structural Analysis

Fong, J. H., Shoemaker, B. A., Garbuzynskiy, S. O., Lobanov, M. Y., Galzitskaya, O. V., & Panchenko, A. R. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000316 · Cited by 118 · see citing works

PTEN enters the nucleus by diffusion

Liu, F., Wagner, S., Campbell, R. B., Nickerson, J. A., Schiffer, C. A., & Ross, A. H. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20525 · Cited by 113 · see citing works

Discovering pathways by orienting edges in protein interaction networks

Gitter, A., Klein‐Seetharaman, J., Gupta, A., & Bar‐Joseph, Z. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1207 · Cited by 109 · see citing works

Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators

Uversky, V. N. (2014) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2014.00006 · Cited by 107 · see citing works

An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein

Hirschi, A., Cecchini, M. J., Steinhardt, R. C., Schamber, M. R., Dick, F. A., & Rubin, S. M. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1868 · Cited by 103 · see citing works

Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

Bolduc, D. M., Rahdar, M., Tu‐Sekine, B., Sivakumaren, S. C., Raben, D. M., Amzel, L. M., Devreotes, P. N., Gabelli, S. B., & Cole, P. A. (2013) · eLife · doi:10.7554/elife.00691 · Cited by 99 · see citing works

Aggregation Propensity of the Human Proteome

Monsellier, É., Ramazzotti, M., Taddei, N., & Chiti, F. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000199 · Cited by 91 · see citing works

PTEN C-Terminal Deletion Causes Genomic Instability and Tumor Development

Sun, Z., Huang, C., He, J., Lamb, K. L., Kang, X., Gu, T., Shen, W. H., & Yin, Y. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.030 · Cited by 89 · see citing works

PTEN in liver diseases and cancer

Peyrou, M. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i37.4627 · Cited by 86 · see citing works

Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders

Kreis, P., Leondaritis, G., Lieberam, I., & Eickholt, B. J. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00023 · Cited by 85 · see citing works

Tumours and tremors: how PTEN regulation underlies both

Kim, R. H., & Mak, T. W. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6602994 · Cited by 83 · see citing works

Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility

Malaney, P., Pathak, R. R., Xue, B., Uversky, V. N., & Davé, V. (2013) · Scientific Reports · doi:10.1038/srep02035 · Cited by 79 · see citing works

Proteome-wide evidence for enhanced positive Darwinian selection within intrinsically disordered regions in proteins

Nilsson, J., Grahn, M., & Wright, A. P. H. (2011) · Genome biology · doi:10.1186/gb-2011-12-7-r65 · Cited by 74 · see citing works

PTEN and myotubularin phosphoinositide phosphatases: bringing bioinformatics to the lab bench

Wishart, M. J., Taylor, G. S., Slama, J. T., & Dixon, J. E. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00195-2 · Cited by 67 · see citing works

The Role of Structural Disorder in the Rewiring of Protein Interactions through Evolution

Mosca, R., Pache, R. A., & Aloy, P. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.014969 · Cited by 63 · see citing works

Chemical composition is maintained in poorly conserved intrinsically disordered regions and suggests a means for their classification

Moesa, H. A., Wakabayashi, S., Nakai, K., & Patil, A. (2012) · Molecular BioSystems · doi:10.1039/c2mb25202c · Cited by 55 · see citing works

The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy

Malaney, P., Uversky, V. N., & Davé, V. (2013) · Molecular BioSystems · doi:10.1039/c3mb70267g · Cited by 51 · see citing works

Is there a biological cost of protein disorder? Analysis of cancer-associated mutations

Pajkos, M., Mészáros, B., Simon, I., & Dosztányi, Z. (2011) · Molecular BioSystems · doi:10.1039/c1mb05246b · Cited by 50 · see citing works

A cyclin D1/cyclin-dependent kinase 4 binding site within the C domain of the retinoblastoma protein.

Pan, W., Cox, S. E., Hoess, R. H., & Grafström, R. H. (2001) · PubMed · Cited by 49 · see citing works

Tools for protein-protein interaction network analysis in cancer research

Pamplona, R. S., Berenguer, A., Solé, X., Cordero, D., Crous‐Bou, M., Serra-Musach, J., Guinó, E., Pujana, M. Á., & Moreno, V. R. (2012) · Clinical & Translational Oncology · doi:10.1007/s12094-012-0755-9 · Cited by 43 · see citing works

Identification of nucleolus-localized PTEN and its function in regulating ribosome biogenesis

Li, P., Wang, D., Li, H., Yu, Z., Chen, X., & Fang, J. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3518-6 · Cited by 40 · see citing works

Nongenomic Mechanisms of PTEN Regulation

Fata, J. E., Debnath, S., Jenkins, E. C., & Fournier, M. V. (2012) · International Journal of Cell Biology · doi:10.1155/2012/379685 · Cited by 34 · see citing works

Intrinsic protein disorder in human pathways

Fong, J. H., Shoemaker, B. A., & Panchenko, A. R. (2011) · Molecular BioSystems · doi:10.1039/c1mb05274h · Cited by 14 · see citing works

The Roche Cancer Genome Database (RCGDB)

Küntzer, J., Eggle, D., Lenhof, H., BURTSCHER, H. J., & Klostermann, S. (2010) · Human Mutation · doi:10.1002/humu.21207 · Cited by 13 · see citing works

Intrinsically disordered proteins play diverse roles in cell signaling

Bondos, S. E., Dunker, A. K., & Uversky, V. N. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00821-7 · Cited by 222 · see citing works

Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time

Aznar, N., Kalogriopoulos, N. A., Midde, K., & Ghosh, P. (2016) · BioEssays · doi:10.1002/bies.201500133 · Cited by 46 · see citing works

Systematic analysis of the PTEN 5′ leader identifies a major AUU initiated proteoform

Tzani, I., Ivanov, I. P., Andreev, D. E., Dmitriev, R. I., Dean, K. A., Baranov, P. V., Atkins, J. F., & Loughran, G. (2016) · Open Biology · doi:10.1098/rsob.150203 · Cited by 43 · see citing works

Precise definition of PTEN C-terminal epitopes and its implications in clinical oncology

Mingo, J., Luna, S., Gaafar, A., Nunes-Xavier, C. E., Torices, L., Mosteiro, L., Ruiz, R., Guerra, I., Llarena, R., Angulo, J. C., et al. (2019) · npj Precision Oncology · doi:10.1038/s41698-019-0083-4 · Cited by 22 · see citing works

Structural and Dynamic Effects of PTEN C-Terminal Tail Phosphorylation

Smith, I. N., Dawson, J. E., Krieger, J., Thacker, S., Bahar, İ., & Eng, C. (2021) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.2c00441 · Cited by 19 · see citing works

The orchestrated signaling by PI3Kα and PTEN at the membrane interface

Kotzampasi, D. M., Premeti, K., Papafotika, A., Syropoulou, V., Christoforidis, S., Cournia, Z., & Leondaritis, G. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.10.007 · Cited by 16 · see citing works

Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress

Jochner, M. C. E., An, J., Lättig-Tünnemann, G., Kirchner, M., Dagane, A., Dittmar, G. A. G., Dirnagl, U., Eickholt, B. J., & Harms, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-39438-1 · Cited by 16 · see citing works

Shape shifting: The multiple conformational substates of the PTEN N‐terminal PIP2 ‐binding domain

Dawson, J. E., Smith, I. N., Martin, W., Khan, K., Cheng, F., & Eng, C. (2022) · Protein Science · doi:10.1002/pro.4308 · Cited by 12 · see citing works

Presence and structure‐activity relationship of intrinsically disordered regions across mucins

Carmicheal, J., Atri, P., Sharma, S., Sushil Kumar, K., Venkata, R. C., Kulkarni, P., Salgia, R., Ghersi, D., Kaur, S., & Batra, S. K. (2020) · The FASEB Journal · doi:10.1096/fj.201901898rr · Cited by 11 · see citing works

The untapped potential of tyrosine-based G protein signaling

Ghosh, P. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.01.017 · Cited by 9 · see citing works

Comparative Protein Structural Network Analysis Reveals C‑Terminal Tail Phosphorylation Structural Communication Fingerprint in PTEN -Associated Mutations in Autism and Cancer

Smith, I. N., Dawson, J. E., & Eng, C. (2023) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.2c06776 · Cited by 6 · see citing works

Intrinsically disordered regions in atypical dual-specificity phosphatases: A review

Pacheco, D. R. D. C. G., Forti, S. F., & Forti, F. L. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147230 · Cited by 4 · see citing works

Elucidating PTEN conformational dynamics and phosphatase regulation via integrative modeling and mutation prediction

Dawson, J. E., Smith, I. N., Tushar, A. M., & Eng, C. (2025) · Structure · doi:10.1016/j.str.2025.06.002 · Cited by 3 · see citing works

An Integrated Approach to Identify Intrinsically Disordered Regions in Osteopontin with its Interacting Network in Rheumatoid Arthritis

Johri, P. K., Singh, S., Sao, P., Banerjee, S., Trivedi, M., Singh, A., & Kostova, I. P. (2022) · Recent Advances in Anti-Infective Drug Discovery · doi:10.2174/2772434417666220908122654 · Cited by 3 · see citing works

A rapid guide to PTEN function

Pulido, R. (2015) · Methods · doi:10.1016/j.ymeth.2015.02.006

A study of translation regulation in cancer by application of ribosome profiling

Tzani, I. (2016) · Cork Open Research Archive (University College Cork, Ireland)

PTEN hamartoma tumor syndrome in children: Identification of recurrent mutations, an unpublished variant and a case of cerebral cortical dysplasia co-occurring with pleuropulmonary blastoma. Review of PTEN-related malformations of cortical developmentPreprint

Csenki, M., Kalmár, T., Zombori, T., Kuthi, L., Vedelek, V., Gábor, M. K., KOBOR, J., & Sztriha, L. (2025) · Research Square · doi:10.21203/rs.3.rs-8070330/v1

Prevalence and Functional Roles of Intrinsic Disorder in the [F-actin]-monooxygenase MICAL Family Members and their Interactors

Ashraf, H. N., & Uversky, V. N. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01978-x

Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility

Malaney, P., Pathak, R. R., Xue, B., Uversky, V. N., & Davé, V. (2013) · Scientific Reports · doi:10.1038/srep02035 · Cited by 79 · see citing works

Intrinsic Disorder and Posttranslational Modifications: The Darker Side of the Biological Dark Matter

Darling, A., & Uversky, V. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00158 · Cited by 236 · see citing works

RESEARCH ARTICLE Evolutionarily Conserved Network Properties of Intrinsically Disordered Proteins

Rangarajan, N., Kulkarni, P., & Hannenhalli, S. S. (2016)

Evolutionarily Conserved Network Properties of Intrinsically Disordered Proteins

Rangarajan, N., Kulkarni, P., & Hannenhalli, S. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126729 · Cited by 17 · see citing works

From multifunctionality to polypathogenicity with intrinsic disorder

Uversky, V. N. (2023) · IMAGINE - Repository of the Institute of molecular genetics and genetic engineering (University of Belgrade)