Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer
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ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTEnzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of CancerWilliam B. Parker*†View Author Information Southern Research Institute, 2000 Ninth Avenue, South Birmingham, Alabama 35205* E-mail: [email protected]. Tel.: 205-581-2797. Fax: 205-581-2447.†Disclosure: Dr. Parker has a financial interest in clofarabine, thio-araC, and the E. coli PNP gene therapy strategy for the treatment of cancer.Cite this: Chem. Rev. 2009, 109, 7, 2880–2893Publication Date (Web):May 29, 2009Publication History Received23 January 2009Published online29 May 2009Published inissue 8 July 2009https://doi.org/10.1021/cr900028pCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views5730Altmetric-Citations426LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (1 MB) Get e-AlertscloseSUBJECTS:Cells,Genetics,Inhibition,Nucleic acids,Peptides and proteins Get e-Alerts
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Gemcitabine and cytarabine are incorporated into DNA, inhibit DNA polymerases, and are commonly used to treat select cancers.
“Other antimetabolite nucleoside analogues, such as gemcitabine and cytarabine, are incorporated into DNA, resulting in inhibition of DNA polymerases, and are commonly used to treat select cancers (Parker, 2009).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Parker, 2009
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- Authors
- Parker, W. B.
- Affiliations
- Southern Research Institute (US)
- Corresponding author
- Parker, William B.
- ORCID
- Parker, William B.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-05-29
- Volume
- 109
- Issue
- 7
- Pages
- 2880-2893
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- PMC
- PMC2827868
- OpenAlex
- W2016956375
- Cited by
- 622
- References
- 99
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- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Chemical Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA124952)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer therapeutics and mechanisms
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Keywords
- purine analogues, pyrimidine antimetabolites, anticancer drug mechanism, enzyme inhibition, thymidine phosphorylase, thymidine kinase, clofarabine, nucleoside metabolism
- MeSH terms
- Antimetabolites, Antineoplastic, Humans, Neoplasms, Purines, Pyrimidines, Drug Design, Genetic Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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