Cited by 622Biochemical and Molecular ResearchCancer therapeutics and mechanismsSynthesis and biological activity

Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer

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Parker, William B.·2009·Chemical Reviews

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTEnzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of CancerWilliam B. Parker*†View Author Information Southern Research Institute, 2000 Ninth Avenue, South Birmingham, Alabama 35205* E-mail: [email protected]. Tel.: 205-581-2797. Fax: 205-581-2447.†Disclosure: Dr. Parker has a financial interest in clofarabine, thio-araC, and the E. coli PNP gene therapy strategy for the treatment of cancer.Cite this: Chem. Rev. 2009, 109, 7, 2880–2893Publication Date (Web):May 29, 2009Publication History Received23 January 2009Published online29 May 2009Published inissue 8 July 2009https://doi.org/10.1021/cr900028pCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views5730Altmetric-Citations426LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (1 MB) Get e-AlertscloseSUBJECTS:Cells,Genetics,Inhibition,Nucleic acids,Peptides and proteins Get e-Alerts

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  • Gemcitabine and cytarabine are incorporated into DNA, inhibit DNA polymerases, and are commonly used to treat select cancers.

    “Other antimetabolite nucleoside analogues, such as gemcitabine and cytarabine, are incorporated into DNA, resulting in inhibition of DNA polymerases, and are commonly used to treat select cancers (Parker, 2009).”

    From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Parker, 2009

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Authors
Parker, W. B.
Affiliations
Southern Research Institute (US)
Corresponding author
Parker, William B.
Venue
Chemical Reviews
Published
2009-05-29
Volume
109
Issue
7
Pages
2880-2893
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
OpenAlex
W2016956375
Cited by
622
References
99
Citations by year
2026: 23 · 2025: 42 · 2024: 56 · 2023: 53 · 2022: 64 · 2021: 41 · 2020: 54 · 2019: 50 · 2018: 39 · 2017: 39 · 2016: 30 · 2015: 28 · 2014: 22 · 2013: 29 · 2012: 19
FWCI
1.28
Type
journal article
Language
en
Open access
Locations
  • Chemical Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (R01CA124952)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer therapeutics and mechanisms
  • Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
Keywords
purine analogues, pyrimidine antimetabolites, anticancer drug mechanism, enzyme inhibition, thymidine phosphorylase, thymidine kinase, clofarabine, nucleoside metabolism
MeSH terms
Antimetabolites, Antineoplastic, Humans, Neoplasms, Purines, Pyrimidines, Drug Design, Genetic Therapy

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