Cited by 41Phytochemical compounds biological activitiesMalaria Research and ControlOrganic Chemistry Synthesis Methods

A facile semisynthesis of the antimalarial drug qinghaosu

Roth, Ronald J., Acton, Nancy·1991·Journal of Chemical Education

Abstract

Semisynthesis of the antimalarial drug.

Integrity signals

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Crossref · 10.1021/ed068p612

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  • The evidence for steps ii)-iv) proposed in Scheme 12 comes solely from in vitro studies conducted with the tertiary allylic hydroperoxide 481.

    “The evidence for steps ii)-iv) which are proposed in Scheme 12 comes solely from in vitro studies, conducted with the tertiary allylic hydroperoxide 481 [171,236,237,239,254], which can be obtained in good yield from photosensitized oxygenation of 480 [193,218].”
  • The semi-synthesis of artemisinin from microbially-produced artemisinic acid requires two further chemical steps: reduction of the exocyclic double bond and photo-sensitized oxidation of the endocyclic double bond to produce the 1,2,4-trioxane ring.

    “The semi-synthesis of artemisinin (495) from microbially-produced artemisinic acid (473) then requires two further chemical steps: reduction of the exocyclic double bond; and photo-sensitized oxidation of the endocyclic double bond to produce the 1,2,4-trioxane ring in (495) [156,237].”

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Sorted by citations

Authors
Roth, R. J., & Acton, N.
Venue
Journal of Chemical Education
Published
1991-07
Volume
68
Issue
7
Pages
612
ISSN
  • 0021-9584 (ISSN-L)
  • 1938-1328
OpenAlex
W2052075786
Cited by
41
References
0
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2018: 2 · 2017: 2 · 2014: 1 · 2013: 1 · 2012: 4
FWCI
0.26
Type
journal article
Language
en
Open access
closed
Locations
Journal of Chemical Education (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Physical Sciences › Chemistry › Organic Chemistry › Organic Chemistry Synthesis Methods
Keywords
artemisinin, semisynthesis, antimalarial drugs

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