Synthesis of 6,7-dehydroartemisinic acid

Total synthesis of qinghaosu

Schmid, G., & Hofheinz, W. (1983) · Journal of the American Chemical Society · doi:10.1021/ja00341a054 · Cited by 329 · see citing works

Stereoselective total synthesis of (+)-artemisinin, the antimalarial constituent of Artemisia annua L

Avery, M. A., Chong, W. K. M., & Jennings-White, C. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00029a028 · Cited by 250 · see citing works

Total synthesis of arteannuin and deoxyarteannuin

Xing-Xiang, X., Jie, Z., Da-Zhong, H., & Wei-Shan, Z. (1986) · Tetrahedron · doi:10.1016/s0040-4020(01)87487-1 · Cited by 181 · see citing works

Total Synthesis of the Antimalarial Sesquiterpene Peroxide Qinghaosu and Yingzhaosu A

Zhou, W.-S., & Xu, X.-X. (1994) · Accounts of Chemical Research · doi:10.1021/ar00043a005 · Cited by 147 · see citing works

Stereoselective synthesis of artemisinin

Ravindranathan, T., Anil Kumar, M., Menon, R. B., & Hiremath, S. V. (1990) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)94621-5 · Cited by 103 · see citing works

On the conversion of dihydroartemisinic acid into artemisinin

Acton, N., & Roth, R. J. (1992) · The Journal of Organic Chemistry · doi:10.1021/jo00039a020 · Cited by 103 · see citing works

A total synthesis of the antimarial natural product (+)-qinghaosu

Hsing-Jang, L., Wen-Lung, Y., & Sew, Y. C. (1993) · Tetrahedron Letters · doi:10.1016/0040-4039(93)88052-k · Cited by 78 · see citing works

Ring opening of artemisinin (qinghaosu) and dihydroartemisinin and interception of the open hydroperoxides with Formation of N-oxides — a chemical model for antimalarial mode of action

Haynes, R. K., Pai, H. H., & Voerste, A. A. W. (1999) · Tetrahedron Letters · doi:10.1016/s0040-4039(99)00830-8 · Cited by 74 · see citing works

Two New Compounds from Artemisia annua

Brown, G. D. (1992) · Journal of Natural Products · doi:10.1021/np50090a006 · Cited by 70 · see citing works

A novel endoperoxide and related sesquiterpenes from Artemisia annua which are possibly derived from allylic hydroperoxides

Sy, L., Brown, G. D., & Haynes, R. K. (1998) · Tetrahedron · doi:10.1016/s0040-4020(98)00148-3 · Cited by 66 · see citing works

Three sesquiterpenes from Artemisia annua

Sy, L., & Brown, G. D. (1998) · Phytochemistry · doi:10.1016/s0031-9422(97)01047-9 · Cited by 62 · see citing works

Practical conversion of artemisinic acid in desoxyartemisinin

Jung, M., ElSohly, H. N., Croom, E. M., McPhail, A. T., & McPhail, D. R. (1986) · The Journal of Organic Chemistry · doi:10.1021/jo00376a070 · Cited by 58 · see citing works

A Novel Asymmetric Total Synthesis of (+)-Artemisinin

Constantino, M. G., Beltrame, M., da Silva, G. V. J., & Zukerman-Schpector, J. (1996) · Synthetic Communications · doi:10.1080/00397919608003621 · Cited by 58 · see citing works

A short and stereospecific synthesis of (+)-deoxoartemisinin and (−)-deoxodesoxyartemisinin

Jung, M., Li, X., Bustos, D. A., ElSohly, H. N., & McChesney, J. D. (1989) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)93831-6 · Cited by 56 · see citing works

Synthesis of (+)-artemisinin and (+)-deoxoartemisinin from arteannuin B and arteannuic acid

Nowak, D. M., & Lansbury, P. T. (1998) · Tetrahedron · doi:10.1016/s0040-4020(97)10286-1 · Cited by 51 · see citing works

Total synthesis of arteannuin (Quinghaosu) and related compounds

Zhou, W.-S. (1986) · Pure and Applied Chemistry · doi:10.1351/pac198658050817 · Cited by 47 · see citing works

Chemical transformations of qinghaosu, a peroxidic antimalarial

Zeng, M.-Y., Li, L., Chen, S., Li, G., Liang, X., Chen, M., & Clardy, J. (1983) · Tetrahedron · doi:10.1016/s0040-4020(01)92155-6 · Cited by 47 · see citing works

A facile semisynthesis of the antimalarial drug qinghaosu

Roth, R. J., & Acton, N. (1991) · Journal of Chemical Education · doi:10.1021/ed068p612 · Cited by 41 · see citing works

Conversion of artemisinin to artemisitene

El-Feraly, F. S., Ayalp, A., Al-Yahya, M. A., McPhail, D. R., & McPhail, A. T. (1990) · Journal of Natural Products · doi:10.1021/np50067a008 · Cited by 40 · see citing works

Asymmetric Reductive Cyclization. Total Synthesis of (−)-C10-Desmethyl Arteannuin B

Schwaebe, M. K., & Little, R. D. (1996) · The Journal of Organic Chemistry · doi:10.1021/jo9600417 · Cited by 34 · see citing works

Epi-Deoxyarteannuin B and 6,7-Dehydroartemisinic Acid from Artemisia annua

El‐Feraly, F. S., Al-Meshal, I. A., & Khalifa, S. I. (1989) · Journal of Natural Products · doi:10.1021/np50061a031 · Cited by 31 · see citing works

New synthetic strategies towards (+)-artemisinin

Bhonsle, J. B., Pandey, B., Deshpande, V. H., & Ravindranathan, T. (1994) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)73532-5 · Cited by 23 · see citing works

Acid Degradation Products of Qinghaosu and Their Structure-Activity Relationships

Imakura, Y., Hachiya, K., Ikemoto, T., Yamashita, S., Kihara, M., Kobayashi, S., Shingu, T., Milhous, W. K., & Lee, K. (1990) · Heterocycles · doi:10.3987/com-90-5396 · Cited by 22 · see citing works

A rearranged hydroperoxide from the reduction of artemisinin

Sy, L., Hui, S.-M., Cheung, K., & Brown, G. D. (1997) · Tetrahedron · doi:10.1016/s0040-4020(97)00444-4 · Cited by 21 · see citing works

Stereoselective oxidations of a β-methylglycal, anhydrodihydroartemisinin

Pu, Y., Yagen, B., & Ziffer, H. (1994) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)76777-3 · Cited by 17 · see citing works

One-Step Stereospecific Synthesis of(-)-Arteannuin B

Jung, M., Yoo, Y., ElSohly, H. N., & McChesney, J. D. (1987) · Journal of Natural Products · doi:10.1021/np50053a040 · Cited by 15 · see citing works

Radiolabeled antimalarials: Synthesis of 14C-artemisinin

Avery, M. A., Bonk, J. D., & Bupp, J. E. (1996) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/(sici)1099-1344(199603)38:3 · Cited by 12 · see citing works

Decomposition of Dihydroartemisitene on Silica Gel

El‐Feraly, F. S., Ayalp, A., Al‐Yahya, M. A., McPhail, D. R., & McPhail, A. T. (1990) · Journal of Natural Products · doi:10.1021/np50070a020 · Cited by 11 · see citing works

Synthesis of epi-deoxy- and deoxyarteannuin B

Acton, N., & Roth, R. J. (1989) · Phytochemistry · doi:10.1016/0031-9422(89)80382-6 · Cited by 10 · see citing works

The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)

Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363 · see citing works

In vivo transformations of dihydroartemisinic acid in Artemisia annua plants

Brown, G. D., & Sy, L.-K. (2004) · Tetrahedron · doi:10.1016/j.tet.2003.11.070 · Cited by 183 · see citing works

Terpenoids from the seeds of Artemisia annua

Brown, G. D., Liang, G.-Y., & Sy, L.-K. (2003) · Phytochemistry · doi:10.1016/s0031-9422(03)00294-2 · Cited by 153 · see citing works

The mechanism of the spontaneous autoxidation of dihydroartemisinic acid

Sy, L.-K., & Brown, G. D. (2002) · Tetrahedron · doi:10.1016/s0040-4020(01)01193-0 · Cited by 129 · see citing works

In vivo transformations of artemisinic acid in Artemisia annua plants

Brown, G. D., & Sy, L.-K. (2007) · Tetrahedron · doi:10.1016/j.tet.2007.06.062 · Cited by 100 · see citing works

A theoretical and experimental study on the molecular and electronic structures of artemisinin and related drug molecules

Galasso, V., Kovač, B., & Modelli, A. (2007) · Chemical Physics · doi:10.1016/j.chemphys.2007.04.008 · Cited by 29 · see citing works

Reactions of Artemisinin and Arteether with Acid: Implications for Stability and Mode of Antimalarial Action

Drew, M. G. B., Metcalfe, J. Z., Dascombe, M. J., & Ismail, F. M. D. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060673d · Cited by 23 · see citing works

Sesquiterpenes from Artemisia annua and Their Cytotoxic Activities

Han, X., Chai, Y., Lv, C., Chen, Q., Liu, J., Wang, Y., & Chou, G. (2022) · Molecules · doi:10.3390/molecules27165079 · Cited by 12 · see citing works

Determination of the antimalaria drug artemether in pharmaceutical preparations by differential pulse polarography

Debnath, C., Haslinger, E., Likussar, W., & Michelitsch, A. (2006) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2005.12.003 · Cited by 12 · see citing works

Chapter 6.4 Six-Membered Ring Systems: With O and/or S Atoms

Hepworth, J. D., & Heron, B. M. (1999) · Progress in heterocyclic chemistry · doi:10.1016/s0959-6380(99)80018-x · Cited by 6 · see citing works

Chapter 6.4 Six-membered ring systems: With O and/or S atoms

Hepworth, J. D., & Heron, B. M. (2002) · Progress in heterocyclic chemistry · doi:10.1016/s0959-6380(02)80017-4 · Cited by 5 · see citing works

Mechanistic Insights into the Nonenzymatic Biosynthesis of Artemisinin and Related Natural Products: A Quantum Chemical Study

Yan, M., Ding, X., Zhao, L., Lü, X., He, H., Fan, S., & Yang, Z. (2025) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c00034 · Cited by 3 · see citing works

Chemical transformations of artemisinin

Семаков, А. В., Afanasyeva, S. V., & Pukhov, S. A. (2025) · Russian Chemical Bulletin · doi:10.1007/s11172-024-4651-6 · Cited by 2 · see citing works

Six-membered Rings with 1,2,4-Oxygen or Sulfur Atoms

Kleinpeter, E. (2008) · Elsevier eBooks · doi:10.1016/b978-008044992-0.00811-7 · Cited by 2 · see citing works

Bicyclic 6-6 Systems: Four Heteroatoms 1:3

Groundwater, P. W., Anderson, R. J., & Nyerges, M. (2008) · Elsevier eBooks · doi:10.1016/b978-008044992-0.00917-2 · Cited by 2 · see citing works

Synthese neuer antimalariaaktiver Verbindungen: Bicyclische Perorthoester mit 1,2,4-Trioxanstruktur und Addukte aus natürlichem Artemisinin mit Peroxidverbindungen

Raabe, A. (2008) · Kölner Universitäts PublikationsServer (Universität zu Köln)

A Simple Differential Pulse Polarographic Method for the Determination of Artemisinin in Artemisia Annua

Debnath, C., Haslinger, E., & Ortner, A. (2006) · Natural Product Communications · doi:10.1177/1934578x0600100611

ChemInform Abstract: Synthesis of 6,7‐Dehydroartemisinic Acid.

Sy, L., & Brown, G. D. (2002) · ChemInform · doi:10.1002/chin.200208189

Synthesis of amorpha-4,11-diene from dihydroartemisinic acid

Schwertz, G., Zanetti, A., de Oliveira, M. N., Fernández, M. A. G., Dioury, F., Cossy, J., & Amara, Z. (2018) · Tetrahedron · doi:10.1016/j.tet.2018.12.050 · Cited by 6 · see citing works

Synthesis of (+)-artemisinin and (+)-deoxoartemisinin from arteannuin B and arteannuic acid

Nowak, D. M., & Lansbury, P. T. (1998) · Tetrahedron · doi:10.1016/s0040-4020(97)10286-1 · Cited by 51 · see citing works

An efficient partial synthesis of (+)-artemisinin and (+)-deoxoartemisinin

Lansbury, P. T., & Nowak, D. M. (1992) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)91851-3 · Cited by 42 · see citing works

Simplified analogs of the antimalarial artemisinin: synthesis of 6,9-desmethylartemisinin

Avery, M. A., Jennings-White, C. L. D., & Chong, W. K. M. (1989) · The Journal of Organic Chemistry · doi:10.1021/jo00269a009 · Cited by 59 · see citing works

Conversion of Dihydroartemisinic Acid into Dihydro‐epi‐deoxyarteannuin B

Chen, H., Hao, H., & Wu, Y. (2015) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201500291 · Cited by 6 · see citing works