The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Methane as a Resource: Can the Methanotrophs Add Value?
Abstract
Methane is an abundant gas used in energy recovery systems, heating, and transport. Methanotrophs are bacteria capable of using methane as their sole carbon source. Although intensively researched, the myriad of potential biotechnological applications of methanotrophic bacteria has not been comprehensively discussed in a single review. Methanotrophs can generate single-cell protein, biopolymers, components for nanotechnology applications (surface layers), soluble metabolites (methanol, formaldehyde, organic acids, and ectoine), lipids (biodiesel and health supplements), growth media, and vitamin B12 using methane as their carbon source. They may be genetically engineered to produce new compounds such as carotenoids or farnesene. Some enzymes (dehydrogenases, oxidase, and catalase) are valuable products with high conversion efficiencies and can generate methanol or sequester CO2 as formic acid ex vivo. Live cultures can be used for bioremediation, chemical transformation (propene to propylene oxide), wastewater denitrification, as components of biosensors, or possibly for directly generating electricity. This review demonstrates the potential for methanotrophs and their consortia to generate value while using methane as a carbon source. While there are notable challenges using a low solubility gas as a carbon source, the massive methane resource, and the potential cost savings while sequestering a greenhouse gas, keeps interest piqued in these unique bacteria.
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Cites
Microbial Fuel Cells: Methodology and Technology
Logan, B. E., Hamelers, B., Rozendal, R., Schröder, U., Keller, J., Freguia, S., Aelterman, P., Verstraete, W., & Rabaey, K. (2006) · Environmental Science & Technology · doi:10.1021/es0605016 · Cited by 6,065
A marine microbial consortium apparently mediating anaerobic oxidation of methane
Boetius, A., Ravenschlag, K., Schubert, C. J., Rickert, D., Widdel, F., Gieseke, A., Amann, R., Jørgensen, B. B., Witte, U., & Pfannkuche, O. (2000) · Nature · doi:10.1038/35036572 · Cited by 3,114
Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates
Anderson, A. J., & DAWES, E. A. (1990) · Microbiological Reviews · doi:10.1128/mmbr.54.4.450-472.1990 · Cited by 2,912
Hanson, R. S., & Hanson, T. E. (1996) · Microbiological reviews · doi:10.1128/mmbr.60.2.439-471.1996 · Cited by 2,772
Exoelectrogenic bacteria that power microbial fuel cells
Logan, B. E. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2113 · Cited by 2,383
Three decades of global methane sources and sinks
Kirschke, S., Bousquet, P., Ciais, P., Saunois, M., Canadell, J. G., Dlugokencky, E. J., Bergamaschi, P., Bergmann, D., Blake, D. R., Bruhwiler, L., et al. (2013) · Nature Geoscience · doi:10.1038/ngeo1955 · Cited by 2,247
Handbook of Hydrocarbon and Lipid Microbiology
(2010) · Springer eBooks · doi:10.1007/978-3-540-77587-4 · Cited by 1,946
A microbial consortium couples anaerobic methane oxidation to denitrification
Raghoebarsing, A. A., Pol, A., van de Pas-Schoonen, K. T., Smolders, A. J. P., Ettwig, K. F., Rijpstra, W. I. C., Schouten, S., Damsté, J. S. S., Op den Camp, H. J. M., Jetten, M. S. M., et al. (2006) · Nature · doi:10.1038/nature04617 · Cited by 1,361
Anaerobic oxidation of methane coupled to nitrate reduction in a novel archaeal lineage
Haroon, M. F., Hu, S., Shi, Y., Imelfort, M., Keller, J., Hugenholtz, P., Yuan, Z., & Tyson, G. W. (2013) · Nature · doi:10.1038/nature12375 · Cited by 1,345
Contribution of anthropogenic and natural sources to atmospheric methane variability
Bousquet, P., Ciais, P., Miller, J. B., Dlugokencky, E. J., Hauglustaine, D. A., Prigent, C., Van der Werf, G. R., Peylin, P., Brunke, E.-G., Carouge, C., et al. (2006) · Nature · doi:10.1038/nature05132 · Cited by 996
Cited by
Knief, C. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01346 · Cited by 594
Methanogens: biochemical background and biotechnological applications
Enzmann, F., Mayer, F., Rother, M., & Holtmann, D. (2018) · AMB Express · doi:10.1186/s13568-017-0531-x · Cited by 437
Microbial protein: future sustainable food supply route with low environmental footprint
Matassa, S., Boon, N., Pikaar, I., & Verstraete, W. (2016) · Microbial Biotechnology · doi:10.1111/1751-7915.12369 · Cited by 390
Renewable methanol and formate as microbial feedstocks
Cotton, C. A., Claassens, N. J., Benito-Vaquerizo, S., & Bar-Even, A. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2019.10.002 · Cited by 359
Guerrero-Cruz, S., Vaksmaa, A., Horn, M. A., Niemann, H., Pijuan, M., & Ho, A. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.678057 · Cited by 336
Metadata
- Authors
- Strong, P. J., Xie, S., & Clarke, W. P.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-03-10
- Volume
- 49
- Issue
- 7
- Pages
- 4001-4018
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W1980731880
- Cited by
- 501
- References
- 121
- FWCI
- 17.63
- Type
- journal article
- Language
- en
- Open access
- closed
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